Jeff Calhoun

@coachnelly.bsky.social caught Oki Oki FC vod today. Awesome to see your progress, keep it up!

You are in for a treat! Pretty sure both were part of episodes of Make Some Noise, possibly Game Changer

Jacob and Vic are gems. That whole crew is talented but imo nothing tops Mr Mayonnaise or Evelyn Tucci

Landscapes of missense variant impact for human superoxide dismutase 1 SOD1 variants cause the motor neuron disease amyotrophic lateral sclerosis. Axakova et al. functionally assay ∼86% of all possible SOD1 missense variants, producing a variant-effect map resource that ...

📣New today!
📄Landscapes of missense variant impact for human superoxide dismutase 1
🧑‍🤝‍🧑 @axakova.bsky.social @fritzroth.bsky.social & co

Search LibGen, the Pirated-Books Database That Meta Used to Train AI Millions of books and scientific papers are captured in the collection’s current iteration.

Just a reminder to check for your name in this list of books that OpenAI trained from. If your name is there, they probably owe you several thousand dollars.

OpenAI cried that if everyone eligible author files, the company will go bankrupt, so I'm alerting every author I have ever spoken to.

World Map of PAX West A) Summit - Entrance at 9th & Pine B) Arch - Entrance at 7th & Pike C) Arch (FKA Annex) - Entrance at 8th & Pike

How To: Queue for entry into the Arch Expo Hall. Doors open at 10:00 am each day.

How to: Queue for entry into the Summit Building. Doors open at 10:00 am each day.

#PAXWest 2025 is a gaming paradise spread across three buildings! Here’s a quick look at how to get around and enter each building.

For more maps & entry details visit PAXwest25.com/Maps

A well earned rest!!

I don't work with fruit flies but even I know how important FlyBase is. Such sad news. 😞

This looks super interesting, thanks for sharing!

EpiPred: A gene-specific machine learning model for classifying missense variants in the epilepsy-related gene STXBP1 https://www.biorxiv.org/content/10.1101/2025.08.09.669488v1

These are so rad!! Love your work 🤩

Happy birthday Gonzo!

This looks super interesting, can't wait to read it!

🚨 Most variant screens measure growth or abundance. What do they miss? That variants impact a spectrum of protein and cellular phenotypes. Variant in situ sequencing (VIS-seq) finds what’s missing: image cells 🔬 first, decode later, revealing multi-scale phenotypes for thousands of variants.👇

1/9

Looks like a very useful resource, thanks for putting it together. Shared it in our lab slack!

I couldn't sleep last night and skimmed through the names on the #BethesdaDeclaration support letter page.

First, the good news.

(1) There were 18,000+ names and it took me 3 hours.

1/n

Thank you to all who joined us in person or online for #VariantEffect25 🌟
📺 Symposium talks are now available on our Youtube channel www.youtube.com/@cmap_cegs8443

See our new paper in @ajhgnews.bsky.social :
Validating data from multiplex assays of variant effect: A CanVIG-UK national survey of NHS clinical scientists
Explores blocks to implementing MAVE data into clinical variant interpretation ‪@varianteffect.bsky.social‬
authors.elsevier.com/a/1lDFkgeXDyy6

ofc said playlist will need a proper name, something along the lines of Kathleen’s LoFi beats to stab to

@kathleen.loadingreadyrun.com Hi Kathleen, on recent TTC Q&A you mentioned sharing a curated lofi beats playlist with @coachnelly.bsky.social any chance you’d share here on blusky too? thanks!! 🙏

Hey @plasmidsaurus.bsky.social, have you heard of DinoCon? 🦖🦕

NSF, NASA and NIH budgets per year, inflation adjusted from 2000-2025 along with the proposed cuts. NSF includes research component only. Massive cuts across all sectors, well below support spanning 25 years.

How bad will it be? Catastrophic.

Proposed cuts to #NSF, #NIH, and #NASA will set the US R&D landscape back 25 yrs+, cause economic and job loss now, and undermine innovations to come.

But, this is the WH's *proposed* budget.

Speak up now before it is too late.

(inflation adjusted $-s below)

Very excited about latest report from @igorulitsky.bsky.social's lab
using an ASO to upregulate CHD2 expression!

CliPE now available in STAR Protocols: www.sciencedirect.com/science/arti...

CliPE now available in STAR Protocols: www.sciencedirect.com/science/arti...

@tychobrahe.bsky.social Have you been keeping tabs on Monster Train 2? Curious to hear your thoughts at some point!

a cartoon character says let 's in front of a green wall ALT: a cartoon character says let 's in front of a green wall

Sometimes I clone with 5+ year expired NEB enzymes just to feel something.

Did You Work on a Terminated NIH Grant? ProPublica Wants to Hear From You. The National Institutes of Health is canceling grants that are seen as conflicting with the Trump administration’s priorities. We want to hear from researchers who have been affected.

We are continuing to look into grant terminations at the NIH, and we want to hear from you.

Please reach out to us with your experiences: www.propublica.org/getinvolved/...

Bravo to ASCB, FASEB, and others for standing up for MOSAIC and other wrongfully terminated programs! 🙌🏾

Cannot emphasize this too strongly.