Van Andel Institute scientists develop technique for high-resolution single cell epigenetic analysis – Van Andel Institute Read about Van Andel Institute scientists develop technique for high-resolution single cell epigenetic analysis on Van Andel Institute – Stay updated on the latest research and groundbreaking discover...

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High-coverage allele-resolved single-cell DNA methylation profiling reveals cell lineage, X-inactivation state, and replication dynamics Nature Communications - Here, the authors describe scDEEP-mC, an improved single-cell whole-genome bisulfite sequencing method for complex libraries and deep genomic coverage, and show advanced...

Our paper on deep single-cell DNA methylation analysis is out in Nature Communications rdcu.be/evfJm. Super elegant work by Nathan Spix describing replication dynamics, X-inactivation, and cell lineage identification.

Epigenetic signatures of intergenerational exposure to violence in three generations of Syrian refugees - Scientific Reports Scientific Reports - Epigenetic signatures of intergenerational exposure to violence in three generations of Syrian refugees

I can't believe we're still allowing completely inadequate and uninterpretable Epigenome-Wide Association Studies (EWAS) to be published.

I don't care that this study is probably well-intentioned, and probably trying to draw attention to awful events in Syria.

www.nature.com/articles/s41...

AACR urges Congress to reaffirm its long history of steadfast and bipartisan support for medical research by ensuring that NIH has all of the resources needed to advance its lifesaving mission to prevent, diagnose, and treat cancer and other diseases: AACR.org/NIH

In Stalin's USSR geneticists were, for political reasons, labelled "fly lovers who hate people" (мухолюбы-человеконенавистники). Soviet genetics died as a field.
A complementary way to kill biomedical research that yields lifesaving medicines is to defund it for equally political reasons:

TRIM28-dependent developmental heterogeneity determines cancer susceptibility through distinct epigenetic states - Nature Cancer Panzeri et al. use a Trim28+/D9 mouse model with intrinsic developmental heterogeneity to show that ‘heavy’ and ‘light’ developmental morphs exhibit different timing, type and severity of cancer, link...

Wondering whether your cancer risk might start before you are born? Our latest work published in #Nature Cancer suggests it does, through regulation by Trim28 and #epigenetic silencing. Congratulations to @ilariapanzeri.bsky.social for spearheading! Read it here: www.nature.com/articles/s43...

DNMT1 loss leads to hypermethylation of a subset of late replicating domains by DNMT3A Loss of DNA methylation is a hallmark of cancer that is proposed to promote carcinogenesis through gene expression alterations, retrotransposon activation and induction of genomic instability. Cancer-...

New pre-print alert 🚨 Interested in what @ikafetzo.bsky.social learned about DNA hypomethylation in cancer from investigating surprising gains DNA methylation in DNMT1 KO cells? Read all about it here: www.biorxiv.org/content/10.1...
For a quick summary see this 🧵 1/8 #epigenetics

New resource available to help scientists better classify cancer subtypes – Van Andel Institute Read about New resource available to help scientists better classify cancer subtypes on Van Andel Institute – Stay updated on the latest research and groundbreaking discoveries in science and health.

www.vai.org/article/new-...

Classification of non-TCGA cancer samples to TCGA molecular subtypes using compact feature sets Ellrott et al. provide a means to assign patient samples from clinical trials and other cancer genome studies to published TCGA molecular subtypes. Applying machine learning to data from five different molecular platforms for 8,791 TCGA tumor samples, they contribute a public resource of 737 top classifier models, which can form the foundation for clinical assay development.

Thrilled to share the results in Cancer Cell of years of hard work to develop classifiers for all major TCGA cancer subtypes, enabling assessment of differential drug response among cancer subtypes in clinical trials. www.cell.com/cancer-cell/...

Van Andel Institute scientists named to prestigious Highly Cited Researchers list – Van Andel Institute VAI scientists Russell Jones, Ph.D., and Peter W. Laird, Ph.D., are included in this year’s Clarivate Highly Cited Researchers list, a distinction marking them as leaders in their fields.

Congratulations to VAI's Dr. Russell Jones and Dr. @peterwlaird.bsky.social for being named to this year's Clarivate Highly Cited Researchers list — a distinction that marks them as leaders in their fields. #HighlyCited2024