Joan

Ever wondered why diseases can affect men and women so differently? 🧐 In this review, we discuss the latest science on sex differences in immunity and how cutting-edge methods enable a holistic view of our immune system and sex-based differences.
#Immunosky 🧬 🧪 🖥️

Ever wondered why diseases can affect men and women so differently? 🧐 In this review, we discuss the latest science on sex differences in immunity and how cutting-edge methods enable a holistic view of our immune system and sex-based differences.
#Immunosky 🧬 🧪 🖥️

Decoding sex differences in human immunity through systems immunology Abstract. Immune function varies widely across humans. Biological sex is a key factor underlying human immune variability, with men presenting with more se

I'm thrilled to share that my first co-authored review, "Decoding sex differences in human immunity through systems immunology," on Oxford Open Immunology! I'm so grateful for the opportunity to have worked with Tianze Cao and @consigliocr.bsky.social on this. doi.org/10.1093/oxfi...

Thanks! Great resource anyway.

Stimulating immune cells in vitro is a common experimental lab model. We profiled 150K blood immune cells treated with 11 different stimuli to compare the effects. The data are freely available for researchers. See the preprint for our findings and to access the data 🧪 doi.org/10.1101/2025...

Very interesting work! Out of curiosity, what was the sex/gender of the individuals? Was it addressed in any way?

Join us for this exciting webinar tomorrow, 24th June 2025 at 14h00 CEST!

@resabut.bsky.social PhD student in my #SystemsImmunology will be speaking ;)

Disentanglement of batch effects and biological signals across conditions in the single-cell transcriptome #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.1101/2025.04.10.648296v1

Integrated analysis of the complete sequence of a macaque genome | Nature The crab-eating macaques (Macaca fascicularis) and rhesus macaques (Macaca mulatta) are pivotal in biomedical and evolutionary research1–3. However, their genomic complexity and interspecies genetic differences remain unclear4. Here, we present a complete genome assembly of a crab-eating macaque, revealing 46% fewer segmental duplications and 3.83 times longer centromeres than those of humans5,6. We also characterize 93 large-scale genomic differences between macaques and humans at a single-base-pair resolution, highlighting their impact on gene regulation in primate evolution. Using ten long-read macaque genomes, hundreds of short-read macaque genomes and full-length transcriptome data, we identified roughly 2 Mbp of fixed-genetic variants, roughly 240 Mbp of complex loci, 16.76 Mbp genetic differentiation regions and 110 alternative splice events, potentially associated with various phenotypic differences between the two macaque species. In summary, the integrated genetic analys

Complete #macaque genome: 46% fewer segmental duplications, 3.83x longer centromeres than humans, and 93 key genomic differences! 📊🐒 #Genomics PMID:40011769, Nature 2025, @Nature https://doi.org/10.1038/s41586-025-08596-w #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Independent effects of testosterone, estradiol, and sex chromosomes on gene expression in immune cells of trans- and cisgender individuals The origins of sex differences in human disease are elusive, in part because of difficulties in separating the effects of sex hormones and sex chromosomes. To separate these variables, we examined gen...

Sex hormones or sex chromosomes?
More mechanistic insights into #sexdifferences in the immune system.
🧪🖥️🧬 #immunosky

www.biorxiv.org/content/10.1...

Sex-biased Transcriptome in in vitro Produced Bovine Early Embryos https://www.biorxiv.org/content/10.1101/2025.03.04.641446v1

Single-cell analysis of aplastic anemia reveals a convergence of NK and NK-like CD8+ T cells with a disease-associated TCR signature NK cells and CD8+ TEMRA cells expressing NK receptors and disease-associated T cell receptors may drive autoimmunity in aplastic anemia.

Single-cell analysis of aplastic anemia reveals a convergence of NK and NK-like CD8+ T cells with a disease-associated TCR signature | Science Translational Medicine www.science.org/doi/10.1126/... #immunosky 🧬🖥️🧪

Tahoe-100M: A Giga-Scale Single-Cell Perturbation Atlas for Context-Dependent Gene Function and Cellular Modeling Building predictive models of the cell requires systematically mapping how perturbations reshape each cell's state, function, and behavior. Here, we present Tahoe-100M, a giga-scale single-cell atlas ...

Over a 1000 compounds :0
www.biorxiv.org/content/10.1...

Interesting that they're unable to predict sex based on the BCR and TCR sequences #sexdifferences #immunosky

www.science.org/doi/10.1126/...

Measuring thymic output across the human lifespan: a critical challenge in laboratory medicine - GeroScience Age-associated thymic involution leads to a significant decline in thymic T cell output, a major contributor to immunosenescence in the elderly. Accurately measuring thymic output is therefore critica...

We wrote a mini-review on how estimating thymic output is actually really hard. Better methods are needed, maybe CD38 is the one marker to rule all Recent Thymic Emigrants? Time will tell. #ImmunoSky #MedSky link.springer.com/article/10.1...

GZMK-expressing CD8+ T cells promote recurrent airway inflammatory diseases - Nature Comparing T cells in nasal polyps from repeated surgeries shows that effector memory-like persistent clones colonize the mucosal tissue during disease recurrence and promote inflammation by producing ...

So THAT'S what Granzyme K does-- cleave complement and promote inflammation in the airway. Fascinating!
#ImmunoSky #AsthmaSky
#InflammationSky
www.nature.com/articles/s41...

Metabolism and metabolites regulating hematopoiesis Energy metabolism of immune cells, such as glycolysis and mitochondrial activity, requires strict regulation. This is especially critical in the compl…

New review in Current Opinion in #Immunology by Baihao Zhang & Sidonia Fagarasan:
"Metabolism and metabolites regulating #hematopoiesis"
#Immunosky

www.sciencedirect.com/science/arti...

Do immune cells from mitochondria have increased mitochondrial enzyme activity? Maybe yes!
doi.org/10.7554/eLif...
#immuo´nosky 🧪🖥️🧬

Really cool approach!

Predicting trajectories of acute illness using RNA velocity of whole blood #SingleCell 🧪🧬🖥️
https://www.researchsquare.com/article/rs-5764288/latest

Differential roles of human CD4+ and CD8+ regulatory T cells in controlling self-reactive immune responses - Nature Immunology Here the authors use a tonsil organoid culture model system to investigate the roles of human CD4+ and CD8+ regulatory T cells in controlling self-reactive immune responses. CD4+ regulatory T cells we...

www.nature.com/articles/s41...
Sex differences in tonsil organoid B cells
#immunosky #medsky #sexdifferences

<em>Clinical & Translational Immunology</em> | ASI Journal | Wiley Online Library Bacille Calmette–Guérin (BCG), the vaccine for tuberculosis, has immunomodulatory effects that may underpin its off-target effects on infectious disease risk and vaccine responses. This study used bl....

I’m excited to share our new study of the off-target effects of #BCGVaccine on response to #SARSCoV2 & #COVID-19 vaccines. We analysed immune responses before & after COVID-19 vaccination in healthcare workers in the #BRACE RCT. 💉🦠 #Immunology #IDsky #Immunosky doi.org/10.1002/cti2...

Lund University’s #SystemsImmunologyLab at #WomensHealth2025 conference!

Great talk from our PhD student @resabut.bsky.social on estradiol’s effects on immunity, and excellent discussions throughout the event on various women’s health topics from endometriosis and PCOS to infections and immunity.

Prior vaccination prevents overactivation of innate immune responses during COVID-19 breakthrough infection SARS-CoV-2 breakthrough infections in previously vaccinated individuals are characterized by reduced activation of innate immune responses.

www.science.org/doi/10.1126/...

Digital health app data reveals an effect of ovarian hormones on long COVID and myalgic encephalomyelitis symptoms https://www.medrxiv.org/content/10.1101/2025.01.24.25321092v1

Our lab's artwork was featured today at #WallenbergCenterForMolecularMedicine's Fusion: Where Science Meets Art.

"Cytokine Heatmap" by Pooja Reddy, MSc student

"Drawing Immune Dynamics: Epitrochoid Patters of Hormone-Modulated Responses" by Joan Escrivá Font @resabut.bsky.social, PhD student

Quantification of escape from X chromosome inactivation with single-cell omics data reveals heterogeneity across cell types and tissues Several X-linked genes escape from X chromosome inactivation (XCI), while differences in escape across cell types and tissues are still poorly charact…

doi.org/10.1016/j.xg...

Quantification of escape from X chromosome inactivation with single-cell omics data reveals heterogeneity across cell types and tissues Several X-linked genes escape from X chromosome inactivation (XCI), while differences in escape across cell types and tissues are still poorly charact…

Great tool to quantify X chromosome escape
🧬 🖥️ ⑂
Quantification of escape from X chromosome inactivation with single-cell omics data reveals heterogeneity across cell types and tissues
www.sciencedirect.com/science/arti...

Multi-omics reveals immune response and metabolic profiles during high-altitude mountaineering The physiological perturbations induced by high-altitude exposure in mountain climbers, manifesting as immunological and metabolic deviations, have be…

Sometimes I feel like I am climbing the mountain of email.

But...

Well THIS paper didn't just feel it; they made science out of it.

Yes it seems that mountain climbing radically rewires your immune system & your metabolism!!

So amazing 😍

🧪
🧬 💻
#genomics

www.sciencedirect.com/science/arti...