Tomos Oliver Prys-Jones

I've done this exact same thing

27.09.2025 18:52 — 👍 0    🔁 0    💬 0    📌 0

Exploring trade-offs in diagnostic algorithm, population coverage, and duration of community screening for tuberculosis Background Current tuberculosis (TB) prevention and care strategies have failed to reduce disease burden at the pace required to meet global targets. Community screening may enable more rapid declines...

Community screening for #tuberculosis could extend the reach of #TB services, but evidence on its effectiveness is limited.

In our latest preprint, we examine the epidemiological impact of trade-offs in diagnostic algorithm, population coverage, and duration of screening. 1/n

bit.ly/3UK7pFD

27.08.2025 14:55 — 👍 12    🔁 7    💬 1    📌 2

Figure 1. Estimated number of trial endpoints in the control group of a prevention-of-disease vaccine trial in a high disease-burden setting showing number of endpoints on the y-axis and time in months on the x-axis. For bacteriologically confirmed symptomatic tuberculosis disease endpoints only, we estimate 69 endpoints, and for combined bacteriologically confirmed asymptomatic and symptomatic tuberculosis disease endpoints, we estimate 151 endpoints. Scenario assumes symptomatic disease incidence before trial screening of 300/100 000 per year and following 10 000 individuals over 3 years. Prevalent symptomatic and asymptomatic tuberculosis disease are screened out in month 0 and are not trial endpoints. Active screening occurs every 6 months for both scenarios and participants self-presenting with symptoms suggestive of tuberculosis disease would also be investigated.

In our latest personal view in @lancetrespirmed.bsky.social, we argue for the inclusion asymptomatic #tuberculosis in vaccine trial endpoints to potentially reduce the size, length, and cost of trials.

doi.org/10.1016/S221...

@lshtm-tbmod.bsky.social @tb-lshtm.bsky.social

04.07.2025 11:25 — 👍 14    🔁 14    💬 3    📌 0

Palestinians fleeing northern Gaza on 9 November 2023 amid Israel's bombardment and siege of the enclave, and intense fighting between the Israeli military and Hamas fighters in the north. Credit: Mohammed Zaanoun/TNH

LSHTM's Director writes to UK Government about #Gaza public health catastrophe

Professor Liam Smeeth's letter to the Prime Minister & Foreign Secretary urges action to prevent a greater #PublicHealth disaster:

👉 www.lshtm.ac.uk/newsevents/n...

20.06.2025 13:32 — 👍 27    🔁 19    💬 0    📌 3

A new beginning #goodbyeX #Bali #MonkeyBusiness

18.11.2024 12:59 — 👍 1    🔁 0    💬 0    📌 0

Reflecting on this year’s #TB #UnionConf2024 and am so inspired by the brilliant minds and groundbreaking research being done to combat this global health threat. Special shoutout to the TB Modelling Group @lshtm.bsky.social 🫁

17.11.2024 19:56 — 👍 21    🔁 6    💬 4    📌 2