Dynamic allele usage of X-linked genes ameliorates neurodevelopmental disease phenotypes in brain organoids Nature Communications - During development of eutherian females, one of the X-chromosomes is silenced. Here, authors show that alleles on the inactive X-chromosome are dynamically expressed along...

We are super excited to share our collaborative work with @svenfalklab.bsky.social here at @fau.de and in collaboration with the great Susann Schweiger in the Human Genetics in Mainz. We found that dynamic X-chromosomal reactivation can ameliorate disease phenotypes!
www.nature.com/articles/s41...

Great environment! Great PI!!!

Cellular interplay in brain organoids: Connecting cell-autonomous and non-cell-autonomous mechanisms in neurodevelopmental disease The field of brain organoids has experienced a period of rapid and transformative growth, enabling researchers to investigate complex human biological…

www.sciencedirect.com/science/arti...

Come join us in Erlangen for an exciting meeting and plenty of opportunities to interact and exchange!!

This international symposium will feature recent advances in the field of brain mechanics,offering opportunities for scientific exchange,oral and poster presentations and interdisciplinary networking.

🗓️ Early bird registration deadline:June 2,2025
🔗 Further information/registration: go.fau.de/1bgia

This was great collaboration!

Tomohisa Toda mit Joseph-Altman-Award geehrt Tomohisa Toda, Professor für neurale Epigenomik an der Friedrich-Alexander-Universität Erlangen-Nürnberg, erhält den Joseph-Altman-Award.

Prof. Tomohisa Toda erhält den Joseph-Altman-Ward 🏆 Herzlichen Glückwunsch!

Toda untersucht den Alterungsprozess des menschlichen Gehirns anhand von langlebigen zellulären Komponenten. Der Preis ist mit 10.000 US-Dollar dotiert.

👇 Mehr erfahren: www.fau.de/2025/03/news...

Neuronal hyperactivity in neurons derived from individuals with gray matter heterotopia - Nature Communications Periventricular heterotopia (PH) is associated with neurodevelopmental delay. Here authors report patient-derived organoids with FAT4 and DCHS1 mutations mimic PH features, showing hyperactivity, syna...

www.nature.com/articles/s41...