The Woo Lab

We hope you all enjoyed Christina's talk as much as we enjoy sharing our science! Seems like it was a packed house 🫡

Small molecule splicing modulators that disrupt O-GlcNAc homeostasis - Nature Communications Authors report drug repurposing screens against O-GlcNAc cycling enzymes, finding kinase inhibitors that act as splicing modulators to disrupt O-GlcNAc homeostasis and downregulate OGT and OGA. These ...

Roses are red, GlcNAc is blue, sugar is sweet, and we want YOU to read our latest in @natcomms.nature.com — where we identify small-molecules that disrupt OGlcNAc homeostasis via RNA splicing. Congrats Steven (@scheng23.bsky.social) and all the authors! 🟦🍭❤️ www.nature.com/articles/s41...

Another Woo Lab Dr. is in: Congrats to our newest Ph.D, Dr. Alison Mody!🫡 Cheers to a wonderful Ph.D. and a sweet (pun intended) thesis talk, all the world’s alpacas are celebrating with you in spirit 🦙🩵🟦💐🎉

🙌🏼🩵

echoing what we said on the other app 😉: we couldn’t have done it without you, our Cryo-EM Queen!! 🙌🏼👑✨🩵

we hope you enjoyed this paper as much as we do! 😉😘

if you’re interested in working with an allosteric ligand, reach out to Prof. Woo 🫡 we’re more than happy to share 🙌🏼🩵✨ #thefutureisallostery #CRBN #TPD

Thank you Carolyn!! Very excited to share this work 🫶🏼

Identification of an allosteric site on the E3 ligase adapter cereblon - Nature An allosteric site on the E3 ligase adapter cereblon can be targeted to modulate the efficacy of cereblon in targeted protein degradation applications.

Exciting new work from @thewoolab.bsky.social just out @nature.com

www.nature.com/articles/s41...

While allostery is biochemical cooperation, this was an epitome of scientific collaboration💙. We'd like to thank our collaborators at GSK and the Lander Lab at Scripps, without whom this work would not have been possible 💙💐🤝

Pour a glass of champagne AND red Bordeaux—Our newest work with GSK @scripps.edu is out in @nature.com! Here we describe SB-405483, the first allosteric CRBN ligand which potentiates neosubstrate degradation. Congrats Vanessa and all authors! 🍷💫💐 www.nature.com/articles/s41...

He’s gonna be gonna be golden! ⭐️ While we’re sad that our beloved postdoc, Dr. Zhenguang Zhao, is leaving, we’re excited for his next steps as he becomes Prof. Zhao at China Pharmaceutical University! 🤩✨🌟

wow! Thanks for the shoutout 🥹 Hopefully our papers in the coming year will continue to impress 😉

stay tuned!!

PCMT1 generates the C-terminal cyclic imide degron on CRBN substrates - Nature Chemical Biology The enzyme PCMT1 was found to install a C-terminal cyclic imide modification on proteins that marks them for degradation by CRBN, uncovering a conserved protein turnover pathway with implications in m...

Last paper post of the year!

Amazing @natchembio.nature.com paper by @thewoolab.bsky.social. PCMT1 installs cyclic imides at the C-terminus of proteins via SAM-dependent methyl ester formation, which then leads to degradation using cereblon.

www.nature.com/articles/s41...
#ChemSky #ChemBio #TPD

PCMT1 generates the C-terminal cyclic imide degron on CRBN substrates - Nature Chemical Biology The enzyme PCMT1 was found to install a C-terminal cyclic imide modification on proteins that marks them for degradation by CRBN, uncovering a conserved protein turnover pathway with implications in m...

We’re popping the champagne prior to New Year’s because our work on how PCMT1 enzymatically forms the CRBN degron is officially out in Nature ChemBio🥂!! Congrats to Zhenguang, Wenqing, Ethan, Shiyun, and all the authors! 🎉💜🍾

www.nature.com/articles/s41...

Let us take you to the land of sweets with our latest work in
@CellChemBiol ! Excited to share this proximity-induced target O-GlcNAc approach, where we uncover transcriptional effects of O-GlcNAc. Congrats to Alison and Dan! 🟦🍭🍬🎵❄️https://sciencedirect.com/science/article/pii/S2451945625003538

After some ~technical difficulties~ the Woo Lab is officially (back) on BlueSky!! Apologies for ignoring all the love for the past month 😅 Excited to share some exciting science on this platform 😉✨💜