FrankeLab

Congratz! 🎉

Post-Docs We are currently recruiting for two post-doc positions in the Lichman lab that require similar skills and experience. We aim to do a joint recruitment process with a single interview. If you apply...

Hello! We are currently hiring for two post-doc positions on projects related to plant natural products, enzymes, and developing new systems to make useful small molecules. More details on our website: lichmanlab.weebly.com/post-docs.html

#PlantSciJobs #PlantSciJob

Wissenschaftliche Mitarbeit: chemische und molekulare Ökologie trophischer Pflanzen-Insekten-Interaktionen.

@unihohenheim.bsky.social in Stuttgart, Germany

Start: 1 März 2026
Deadline: 19 Oktober 2025
www.deutsche-botanische-gesellschaft.de/stellenangeb...

Naming Challenge: Help Redefine the Glycopeptide Family! We are excited to launch a naming competition inspired by the recent preprint "Phylogenetic distance and structural diversity directing a reclassification of glycopeptide antibiotics" (https://www.bio...

⏰ Just 7 days left for our Glycopeptide Renaming Challenge!
💡 Share your best name idea and win 500€

👉 More info and submission here: docs.google.com/forms/d/1ym9...

#secmet #NaturalProducts #Antibiotics #NamingChallenge #Glycopeptides @gdwantibiotics.bsky.social @marghesosio.bsky.social

Ein wirklich toller Artikel, absolut lesenswert! 👍

Nancy Choudhary, Institut für Zelluläre und Molekulare Botanik an der Universität Bonn, bei der Durchführung der Genomsequenzierung der Pflanze Withania somnifera. (Bildquelle: Julie Anne V.S. de Oliveira)

Nachschattengewächse als Basis für Arzneimittel: Forschungsteams der #LUH und der @unibonn.bsky.social‬ entschlüsseln Gensequenz zur Bildung von Steroiden. @dfg.de‬ fördert das Projekt mit rund 511.00 Euro. http://go.lu-h.de/aNhrb

And make sure to also check out the excellent work on the withanolide biosynthetic gene cluster by Claude Becker's group
www.pnas.org/doi/10.1073/...
and by Jing-Ke Weng's group:
www.biorxiv.org/content/10.1...

Big thanks also to anonymous Reviewer 1. Their supportive and constructive report led us to discover the role of the dehydrogenase SDR in the biosynthetic pathway. This is how peer review should work. 👏

Phylogenomics and metabolic engineering reveal a conserved gene cluster in Solanaceae plants for withanolide biosynthesis Nature Communications - Withanolides are plant steroids with potent bioactivities found in many medicinal plants including Withania somnifera, but their biosynthetic pathway is largely unknown....

Extremely happy to see our withanolide biosynthesis paper out in @natcomms.nature.com‬ rdcu.be/evHOF
Fantastic team effort with the Pucker group @bpucker.bsky.social‬ @puckerlab.bsky.social‬ at @unibonn.bsky.social and Heretsch, Herde and Witte groups at @unihannover.bsky.social. Funded by @dfg.de

There is still time to apply 👇
#MSCA #Postdoc #Biotech #Bioinformatics #Genomics

Elucidation and recreation of the biosynthetic pathway for taxol | Plantae Paclitaxel (sold as Taxol) is taxane diterpene natural product of yew trees (Taxus spp.) and a potent stabilizer of microtubules that is effective in treatment of cancers. However…

Plant Science Research Weekly -- Elucidation and recreation of the biosynthetic pathway for taxol (Nature) @cmcclune.bsky.social‬ (Summary by Mary Williams @PlantTeaching.bsky.social)
buff.ly/miccEK3

#PlantaePSRW

A cartoon showing a bacterial Xanthomonas cell injecting TALEs into a plant cell to induce expression of target genes.

PhD position open! 🌾🧫🧬✂️😃 Are you interested in plant pathology and genome editing? Have you ever seen how cool Xanthomonas manipulates the plant cell using TALEs? Don't hesitate to apply! www.uni-hannover.de/en/jobs/id/7...

Dear #molbio buble, can you suggest any (free) software for cloning and sequence analysis? Something similiar to SnapGene (but cheaper) or Benchling (but locally hosted)?
Asking for a newly set up group.

Also check out my News & Views article for more details on the significance of this work 👇
rdcu.be/eqwOy

Discovery of FoTO1 and Taxol genes enables biosynthesis of baccatin III - Nature An approach that combines single-nucleus RNA sequencing and multiplexed perturbation identifies genes that enable the biosynthesis of direct precursors of the anti-cancer drug Taxol, whose curren...

Fantastic work by the Sattely group on taxol biosynthesis, featuring a highly innovative application of single nuclei sequencing to find elusive biosynthetic genes 👏
www.nature.com/articles/s41...

Laboratory Technician, Department of Plant and Environmental Sciences

We're hiring!
🥼 2-year lab technician at UCPH from 01 Aug
🌿 Support our research in plant natural products with relevance in agriculture, nutrition, and medicine.
🧬 Your skills: plant molecular biology and/or tissue culture & transformation
📅 Deadline 18 May 2025
jobportal.ku.dk/administrati...

Expansion of the Stereochemical Space of Triterpenes by Mining Noncanonical Oxidosqualene Cyclases Across the Diversity of Green Plants Triterpenoids and steroids are structurally complex polycyclic natural products with potent biological functions, for example, as hormones. In all eukaryotes, the carbon skeletons of these compounds a...

Started as a very successful master thesis, now published in JACS. Screening sequence similarity networks turned out to be a great way to discover oxidosqualene cyclases with unusual activity from more than thousand plant transcriptome sequence datasets.

pubs.acs.org/doi/10.1021/...

I am trying to find everyone working on plant genomics:
go.bsky.app/NqARJ7V
Please let me know who is already on @bsky.app, but missing in this #PlantGenomics starter pack

What limits rubisco function? Is it the chemical mechanism? Evolution? In this paper, @prywes.bsky.social et. al explore this question by assaying >99% of single amino acid mutants in Form II rubisco (1/7) doi.org/10.1038/s415...

A cellulose synthase–like protein governs the biosynthesis of Solanum alkaloids Decades of research on the infamous antinutritional steroidal glycoalkaloids (SGAs) in Solanaceae plants have provided deep insights into their metabolism and roles. However, engineering SGAs in heter...

A cellulose synthase–like protein governs the biosynthesis of Solanum alkaloids | Science www.science.org/doi/10.1126/... @science.org

The chemical structure of resiniferatoxin, drawn with TWSBI ECO fountain pens in a dark purple and dark gray inks.

Anyone up for some #ToxTuesday?
A lot of us love spicy foods, and the capsaicin in chili peppers that gives us that heat can be addictive. But is there anything hotter? I'm glad you asked. Yes, yes there is. And it's called RESINIFERATOXIN

Awesome job, Omar, congratulations! 👏

We have a fully funded 4-year PhD studenship available that builds on parts of this pre-print:
biodtp.norwichresearchpark.ac.uk/projects/dis...
🗓️ Deadline 25 Nov 2024
Please do get in touch if you're interested!