Emmanuelle Bignon

Our speaker application is still open! Fill out the survey to come share your research with the Fragile Nucleosome community!

Si vous avez des adolescentes qui s'intéressent à l'informatique, je signale qu'il reste des places pour les stages #GirlsCanCode en août et septembre.
C'est gratuit et vraiment top. Mes aînées les ont fait en 2018 et 2022, là je viens d'inscrire fille n°3 et elle est ravie.
girlscancode.fr

📣💻[JOB OFFER] I am looking for a postdoc with experience in QM/MM, MD and biosystems, and who would be motivated to study the formation mechanisms of oxydative histone modifications. Please share! #compchem #histones #PTM #redox #DNA
emploi.cnrs.fr/Offres/CDD/U...

European Citizens' Initiative Give your support !

L'initiative européenne visant à interdire les thérapies de conversion dépasse les 500 000 signatures, avec une cadence de 120 par minute dans toute l'Europe !
On doit atteindre 1 million avant la fin de la journée de samedi ! On lâche rien !
eci.ec.europa.eu/043/public/#...

Join us for the next #MDDBwebinar: DynaRepo and beyond, exploring macromolecular dynamics, allosteric signaling & binding site predictions - presented by researchers from Inria and LPCT, Université de Lorraine, France.

🗓️ May 27, 13:00 CEST
More info 🔗 bit.ly/43rQKeT

#MDDB #OpenScience #FAIRdata

Histone H3 cysteine 110 enhances iron metabolism and modulates replicative life span in Saccharomyces cerevisiae Histone H3 cysteine 110 enhances iron metabolism and modulates replicative life span in yeast.

Ever wondered what the lonely histone H3C110 does? We found that it’s lost in many fungi. Adding it back boosts histone H3 copper reductase activity, rescues iron defects and modulates lifespan, suggesting an evolutionary tradeoff between these effects.
www.science.org/doi/10.1126/...

Take a look at our new collaboration project with the Phil Cole lab, we demonstrate how SIRT6 can recognize and remove a variety of different Histone acylations!

Image de publication

#Agenda Les 27 février, 3 mars et 4 mars 2025, l’association Femmes & Sciences organise des journées pour les lycéennes du Grand Est. Rencontres avec des femmes scientifiques et visites de labos pour déconstruire les stéréotypes et inspirer
➕ d'infos 👉 https://www.sharee.me/t/jkLw!

I was a real pleasure to discuss about #stereotypes and #gender #bias for this international day of #women and #girls in #science! Thank you for the invitation! 😀 #GWB2025

Today we are happy to welcome @emmabignon.bsky.social for the #GWB2025 at @itodys.bsky.social @upcite.bsky.social @ctm-itodys.bsky.social
Very interesting meeting

GitHub - Lemkul-Lab/gamd_livecoms_tutorial Contribute to Lemkul-Lab/gamd_livecoms_tutorial development by creating an account on GitHub.

We have a new #tutorial posted online, this time for Gaussian-accelerated MD as implemented in NAMD. Article has been submitted to LiveCoMS, a great venue for such efforts. We welcome feedback! Yes, it's alanine dipeptide, but you have to start somewhere :) #compchem

github.com/Lemkul-Lab/g...

It is still possible to apply to this postdoc position in my group if you are motivated by using your QM/MM and MD skills to study the fascinating histone post-translational modifications! 🥳
Deadline is the 1st of March #job #compchem #histones #DNA
Apply on the CNRS website : lnkd.in/eNxR-TPH

Postdoctoral Research Associate in Biochemistry and Molecular Genetics – Weaver Lab in Charlottesville, Virginia, United States of America | Research at University of Virginia Apply for Postdoctoral Research Associate in Biochemistry and Molecular Genetics – Weaver Lab job with University of Virginia in Charlottesville, Virginia, United States of America. Research at Univer...

My lab is looking to hire a Postdoc to study mechanisms of DNA repair in chromatin using biochemical, biophysical, and structural biology approaches! Feel free to share with anyone you think may be interested.

jobs.virginia.edu/us/en/job/R0...

Structural basis for the inhibition of PRC2 by active transcription histone posttranslational modifications - Nature Structural & Molecular Biology Structures reveal that histone H3K36me3 and H3K4me3 modifications reduce Polycomb repressive complex 2 (PRC2) function through the inhibition of histone tail engagement and antagonistic binding to the...

Work led by graduate student @trinitycookis.bsky.social and coauthors Alexandria Lydecker, @paulsauer.bsky.social, and @kasinath-lab.bsky.social is out today where we looked at the inhibition of PRC2 by histone PTMs associated with regions of active transcription.

www.nature.com/articles/s41...

Histone H3.1 is a chromatin-embedded redox sensor triggered by tumor cells developing adaptive phenotypic plasticity and multidrug resistance Palma et al. report that H3.1Cys96 oxidation is a functional posttranslational modification involved in the regulation of gene expression. In breast cancer, H3.1Cys96 oxidation promotes resistance to first-line chemotherapeutic drugs and stimulates metastasis. They also show that suppressing H3.1Cys96 oxidation inhibits metastasis while resensitizing cancer cells to chemotherapy.

2024 - the year when we showed that chromatin structure is responsive to ROS regulation because of redox sensitive histone variants - more #redoxepigenetics in 2025 folks - thanks 2024 looking forward to an awesome 2025 www.cell.com/cell-reports...

These proteins have been secretly managing your cells Scientists have long known that histones spool DNA and help regulate genes. They may be doing a lot more.

Scientists have long known that histones spool DNA and help regulate genes. They may be doing a lot more.
www.asbmb.org/asbmb-...

📢 Save the date!

Our next workshop by @cecamevents.bsky.social will explore MD database generation, centering in biomacromolecular systems and advancing a FAIR paradigm for MD simulations.

📅 October 15-17, 2025
📍 Lausanne, Switzerland

More details ➡️ bit.ly/3P8ezAs

#MDDB #FAIRdata #openscience

Open #PhDposition: decipher the mechanisms underlying allostery.

What allows a protein to communicate over many nanometers to regulate its function? How did it evolve? What is the link to protein dynamics?
Join us to study exciting mechanisms by NMR & more.

More info attached.
phd.pages.ista.ac.at

a penguin wearing blue overalls and a red bandana says we need you Alt: a penguin wearing blue overalls and a red bandana says we need you

Le LBT se cherche un·e administrateurice systèmes et réseaux. Pour le moment le poste est ouvert en NOEMI (mobilité), donc si vous êtes déjà en poste et souhaitez nous rejoindre, c'est par ici !
mobiliteinterne.cnrs.fr/ords/afip/ow...

Emmanuelle Bignon on LinkedIn: Job offer - pdoc CHROM 📢🧬I have a postdoc position open for people with experience using QM/MM on biosystems! Do not hesitate to apply if you're interested in investigating the…

First post here, how exciting!! 🥳
📣💻[JOB OFFER] I am looking for a postdoc with experience in QM/MM, MD and biosystems, and who would be motivated to study the formation mechanisms of oxydative histone modifications. Please share! #compchem #histones #PTM #redox
www.linkedin.com/posts/activi...