Have a look at this image from the lab, taken by @katkajerabkova.bsky.social, and vote for it as it is competing for the Grand Public Prize of the @sbcf.bsky.social

🚨 New EMBO Practical Course!
Ultrastructure Expansion Microscopy: From Cells to Tissue 🔬
📅 20–24 Apr 2026 | 📍 EMBL Heidelberg
Co-organised with @banterlegroup.bsky.social @gautamdey.bsky.social

💡 Register your interest to get notified when registration opens:

🔗 www.embl.org/about/info/c...

The nucleus is fantastic, but can it beat #cilia and #flagella 😉 here stained for tubulin (magenta) with an intraflagellar transport train (green) after #expansion microscopy and #STED or shown by classic TEM. JCS @jcellsci.bsky.social found the solution and is featuring both! 😍

@cnrsecologie.bsky.social regrette profondément l'adoption de cette loi à la vision court-termiste & ses conséquences graves sur l’environnement, qui méprise santé & bien-être de la population & le rôle des espèces sauvages dans la prod. agricole. La communauté scientifique n'a pas été entendue.

🚨 #ExM meets #eSRRF 🔬🏄🌊 the full protocol now in ‪@natprot.nature.com‬: doi.org/10.1038/s415...

🔬👨‍💻📰 #SReD is out!
Automated structural detection for #ImageJ & #FIJI, from nano to macro ✨🐘. No training data, no bias - texture analysis with GPU acceleration!⚡️
Brainchild of @afonsomendes92.bsky.social and adventure w @christlet.bsky.social lab + friends.

Check: www.nature.com/articles/s41...

Root expansion microscopy: A robust method for super resolution imaging in Arabidopsis Root expansion microscopy (ROOT-ExM) achieves super-resolution expansion microscopy in plants.

Finally out!, after a few months of delay, our protocol on ExM in plant roots is now available in The Plant Cell
academic.oup.com/plcell/artic...
Beautiful images in a great collaboration of the @bic-bordeaux.bsky.social with @emmanuellebayer.bsky.social and Magali Grison @lbm-bordeaux.bsky.social

🚨 New preprint!
Using U-ExM + in situ cryo-ET, we show how C2CD3 builds an in-to-out radial architecture connecting the distal centriole lumen to its appendages. Great collab with @cellarchlab.com @chgenoud.bsky.social @stearnslab.bsky.social 🙌. #TeamTomo #UExM
www.biorxiv.org/content/10.1...

Proud to share our latest paper. doi.org/10.1016/j.cr...

Through the dedication of @glynnca.bsky.social and @cryingem.bsky.social we report a thorough method to image molecular organisation within hippocampus tissue.

Structural biology in tissue is well and truly here!

@rosfrankinst.bsky.social

Expansion microscopy image, and accompanying sketch, of S. arctica nucleus with labelled microtubules and nuclear pore complexes.

9/ The observed patterns matched our model, and their parameters place these systems near the predicted optimal filtering regime -- These NPCs may act as efficient spatial thresholding filters! #Microscopy #QuantBio #Microtubules #UExM

Three full days of #ExM in Bordeaux. Onsite practical course on expansion microscopy. We will be sharing very soon the theoretical and application courses.

Light-microscopy-based connectomic reconstruction of mammalian brain tissue - Nature A technique called LICONN (light-microscopy-based connectomics) allows mapping of brain tissue at synapse level and simultaneous measurement of molecular information, thus enabling quantification of c...

Thanks to expansion microscopy, clever labeling, and modern segmentation approaches, doing connectomics with #light #microscopy has become feasible - huge congratulations Mojtaba & the Danzl lab at @istaresearch.bsky.social !
www.nature.com/articles/s41...

🚨🔬💗Whether investigating cell organelles or mapping proteins, together with Victor Puelles's lab we lay a roadmap for selecting optimal #ExM and #SuperResolution #microscopy combinations. Daria Aristova and Dominik Kylies review with amazing co-authors

pubs.aip.org/aip/apr/arti...

Happy #fluorescentFriday: dendritic spines of Purkinje cell after 10x expansion microscopie #expansionMicroscopie #ExM

Labeling of RXFP1/DRD1/OPRM1 in tissue section of human brain through the nucleus accumbens using single molecule fluorescence in situ hybridization

I will never tire of looking at these clusters of DRD1🔴/RXFP1🟡/OPRM1🟣 cells - here showing RNAscope in nucleus accumbens of human 🧠. Patterning of them is so neat!

New lab preprint! Unveiling the Molecular Architecture of T Cells and Immune Synapses with Cryo-Expansion Microscopy (Cryo-ExM). A fantastic collaboration with Dr. Benita Wolf. Congratulations to all authors, especially Florent Lemaitre, for leading this amazing work! www.biorxiv.org/content/10.1...

Incredible 4Pi and pan-expansion imaging of the Golgi 👇

Mouse brain slices, unexpanded and at two different expansion levels, prepared using expansion microscopy.

I don't think I'm ever going to get tired of expansion microscopy, so this makes for a great first post here to look back on in the years to come 😄

Mouse brain slices, unexpanded and at two different expansion levels, skillfully prepared by @damstra.bsky.social and Aashir Meeran at E11 Bio! 🧠

Hi, you can have a look to the ITI Neurostra website neurostra.unistra.fr/en/neurostra...

to reach neuroscientists in Strasbourg!

"Imagine a DAPI-like stain, but for the extracellular matrix." That's basically how this work was pitched to me by Kayvon and Antonio a year or so ago. Now the final product really delivers. Read about their versatile label for ECM in living tissues here: www.nature.com/articles/s41...

The most beautiful neurons in the brain (fact), and also my villain origin story - #FluorescenceFriday

🧡 biocytin patched and filled Purkinje cell
💚 parvalbumin
💜 AnkG for axon initial segments

Thank you ! Indeed, hope to post nice ExM images soon!

Hello, could you add me please ?

I created a starter pack for Imaging Scientists that work in core facilities.

I'm sure I missed lots of people since I searched for those that have "core" or "facility" in their bios, so let me know who else should be added!

go.bsky.app/2bbgRQU

Excited to share our latest findings, now published @NatureNeuro www.nature.com/articles/s41...

We found unmyelinated axons exhibit pearls-on-a-string morphology's due to their membrane mechanical properties.

Threads will follow!

Another piece that was a doozie. This is a rendering of Cajal's famous Purkinje neuron. It took me 20 hours to cut it. It measures 2ftx3ft. I can make it again on demand. #beautifulbrain