France-BioImaging A National Research Infrastructure for Biological Imaging

Go on our website to explore it 👉 france-bioimaging.org

The new FBI website is out!

We are pleased to present our redesigned website which has been built to simplify our users' journey whether from academia / industry

We have developed new features such as:
➡️Interactive map
➡️Services page to help you identify the technologies best suited to your needs

[PUBLI] A recent collaboration between the Irset Institute & the H2P2 platform (FBI Bretagne-Loire node) has introduced a new imaging protocol to explore the immune microenvironment of HCC using multiplex immunofluorescence.

Read more in our article 👉 france-bioimaging.org/announcement...

emploi.cnrs.fr/Offres/MOBIN... offre de mobilité pour les collègues ingénieurs du CNRS, préparation d'échantillons (transparisation, expansion microscopy...) et plus 🔬, à Strasbourg ! Merci de relayer !

Wow 😍 What labelling?

[PUBLI] Improving DNA-PAINT with a fluorogenic DNA probe

A team led by Yves Mely (LBP/Strasbourg University) in collab with Alain Burger's team (ICN) developed DRET-PAINT, a new approach that enhances super-resolution microscopy!

🔗Read our article: france-bioimaging.org/announcement...

Very glad to be in Beijing at PKU for the Sino-French exchange on biomedical imaging infrastructures. Many thanks to @france-bioimaging.bsky.social, Laurent Bourdieu, Liangyi Chen and many others for the organization!

Mesoscale volumetric fluorescence imaging at nanoscale resolution by photochemical sectioning Optical nanoscopy of intact biological specimens has been transformed by recent advancements in hydrogel-based tissue clearing and expansion, enabling the imaging of cellular and subcellular structure...

for #FluorescenceFriday : is your ExM sample too large to be imaged with high NA objectives? VIPS it! Very clever way to tackle one of the biggest challenge in large volumetric ExM www.science.org/doi/10.1126/...

Great first poster session at #Mifobio2025 — thanks for the inspiring discussions! 🔬
All week long, come (re)discover our poster and explore #OpenCID, making #data #storage, #management & #sharing simpler.
See you soon!

@gdrimabio.bsky.social
@imag-ic.bsky.social

"On est obligé de refuser des gens !" : 350 chercheurs et scientifiques du monde entier réunis dans les Landes pendant une semaine 350 chercheurs, ingénieurs, mathématiciens, chimistes, biologiques, physiciens... vont passer huit jours ensemble à Seignosse, du 10 au 17 octobre. L'objectif : partager leurs savoirs. Ce rassemblemen...

📰 #Mifobio dans la presse

👉 france3-regions.franceinfo.fr/nouvelle-aqu...

Merci @france3-naquitaine.bsky.social pour cet article sur #Mifobio2025

@cnrs.fr @cnrsingenierie.bsky.social @institutfresnel.bsky.social @healthcare.nikon.com @leicamicrosystems.bsky.social @abbelight.bsky.social

🔥 It's Time ! #Mifobio2025

👉 imabio-cnrs.fr

#GDRImabio

@cnrs.fr
@cnrsingenierie.bsky.social
@cnrsbiologie.bsky.social

Have a look at this image from the lab, taken by @katkajerabkova.bsky.social, and vote for it as it is competing for the Grand Public Prize of the @sbcf.bsky.social

🚨 New EMBO Practical Course!
Ultrastructure Expansion Microscopy: From Cells to Tissue 🔬
📅 20–24 Apr 2026 | 📍 EMBL Heidelberg
Co-organised with @banterlegroup.bsky.social @gautamdey.bsky.social

💡 Register your interest to get notified when registration opens:

🔗 www.embl.org/about/info/c...

The nucleus is fantastic, but can it beat #cilia and #flagella 😉 here stained for tubulin (magenta) with an intraflagellar transport train (green) after #expansion microscopy and #STED or shown by classic TEM. JCS @jcellsci.bsky.social found the solution and is featuring both! 😍

@cnrsecologie.bsky.social regrette profondément l'adoption de cette loi à la vision court-termiste & ses conséquences graves sur l’environnement, qui méprise santé & bien-être de la population & le rôle des espèces sauvages dans la prod. agricole. La communauté scientifique n'a pas été entendue.

🚨 #ExM meets #eSRRF 🔬🏄🌊 the full protocol now in ‪@natprot.nature.com‬: doi.org/10.1038/s415...

🔬👨‍💻📰 #SReD is out!
Automated structural detection for #ImageJ & #FIJI, from nano to macro ✨🐘. No training data, no bias - texture analysis with GPU acceleration!⚡️
Brainchild of @afonsomendes92.bsky.social and adventure w @christlet.bsky.social lab + friends.

Check: www.nature.com/articles/s41...

Root expansion microscopy: A robust method for super resolution imaging in Arabidopsis Root expansion microscopy (ROOT-ExM) achieves super-resolution expansion microscopy in plants.

Finally out!, after a few months of delay, our protocol on ExM in plant roots is now available in The Plant Cell
academic.oup.com/plcell/artic...
Beautiful images in a great collaboration of the @bic-bordeaux.bsky.social with @emmanuellebayer.bsky.social and Magali Grison @lbm-bordeaux.bsky.social

🚨 New preprint!
Using U-ExM + in situ cryo-ET, we show how C2CD3 builds an in-to-out radial architecture connecting the distal centriole lumen to its appendages. Great collab with @cellarchlab.com @chgenoud.bsky.social @stearnslab.bsky.social 🙌. #TeamTomo #UExM
www.biorxiv.org/content/10.1...

Proud to share our latest paper. doi.org/10.1016/j.cr...

Through the dedication of @glynnca.bsky.social and @cryingem.bsky.social we report a thorough method to image molecular organisation within hippocampus tissue.

Structural biology in tissue is well and truly here!

@rosfrankinst.bsky.social

Expansion microscopy image, and accompanying sketch, of S. arctica nucleus with labelled microtubules and nuclear pore complexes.

9/ The observed patterns matched our model, and their parameters place these systems near the predicted optimal filtering regime -- These NPCs may act as efficient spatial thresholding filters! #Microscopy #QuantBio #Microtubules #UExM

Three full days of #ExM in Bordeaux. Onsite practical course on expansion microscopy. We will be sharing very soon the theoretical and application courses.

Light-microscopy-based connectomic reconstruction of mammalian brain tissue - Nature A technique called LICONN (light-microscopy-based connectomics) allows mapping of brain tissue at synapse level and simultaneous measurement of molecular information, thus enabling quantification of c...

Thanks to expansion microscopy, clever labeling, and modern segmentation approaches, doing connectomics with #light #microscopy has become feasible - huge congratulations Mojtaba & the Danzl lab at @istaresearch.bsky.social !
www.nature.com/articles/s41...

🚨🔬💗Whether investigating cell organelles or mapping proteins, together with Victor Puelles's lab we lay a roadmap for selecting optimal #ExM and #SuperResolution #microscopy combinations. Daria Aristova and Dominik Kylies review with amazing co-authors

pubs.aip.org/aip/apr/arti...

Happy #fluorescentFriday: dendritic spines of Purkinje cell after 10x expansion microscopie #expansionMicroscopie #ExM

Labeling of RXFP1/DRD1/OPRM1 in tissue section of human brain through the nucleus accumbens using single molecule fluorescence in situ hybridization

I will never tire of looking at these clusters of DRD1🔴/RXFP1🟡/OPRM1🟣 cells - here showing RNAscope in nucleus accumbens of human 🧠. Patterning of them is so neat!

New lab preprint! Unveiling the Molecular Architecture of T Cells and Immune Synapses with Cryo-Expansion Microscopy (Cryo-ExM). A fantastic collaboration with Dr. Benita Wolf. Congratulations to all authors, especially Florent Lemaitre, for leading this amazing work! www.biorxiv.org/content/10.1...

Incredible 4Pi and pan-expansion imaging of the Golgi 👇

Mouse brain slices, unexpanded and at two different expansion levels, prepared using expansion microscopy.

I don't think I'm ever going to get tired of expansion microscopy, so this makes for a great first post here to look back on in the years to come 😄

Mouse brain slices, unexpanded and at two different expansion levels, skillfully prepared by @damstra.bsky.social and Aashir Meeran at E11 Bio! 🧠

Hi, you can have a look to the ITI Neurostra website neurostra.unistra.fr/en/neurostra...

to reach neuroscientists in Strasbourg!