Soldati Lab

🚨 New preprint!

Together with @carobarisch.bsky.social lab, we investigated how intracellular compartmentalization shapes lipid acquisition in mycobacteria

Interestingly, deleting one FACL enzyme (FACL6) revealed striking compartment-dependent phenotypes 🔬

Check it out: doi.org/10.64898/202...

🎉 Big news! Last Saturday, Thierry was awarded the Egon Naef Foundation Prize for in vitro research 🏆 A wonderful recognition of his innovative work throughout his career developing alternatives to animal testing 👏

www.unige.ch/sciences/chi...

@sciencesunige.bsky.social

🚨 Preprint alert 🚨

In this study, we reveal how a calcium-sensing protein coordinates membrane damage sensing with repair pathways in response to damage from intracellular mycobacteria

Huge congrats to @guallar-garrido.bsky.social for leading this project! 🤩👏

www.biorxiv.org/content/10.6...

Membrane microdomains are crucial for Mycobacterium marinum EsxA-dependent membrane damage, escape to the cytosol, and infection Sterol-rich microdomain accumulation at the MCV is crucial for Mm-induced damage and infection in D. discoideum and BV-2 cells.

🚨 Want to know how we demonstrated the importance of sterol-rich membrane microdomains for M. marinum infection?

Check out our latest paper published in Science Advances 👇
www.science.org/doi/10.1126/...

✨ Big thanks to everyone, especially Cristina Boehm-Bosmani, @soldatilab.bsky.social ! ✨

New paper out! 🚨

We uncover how Mycobacterium marinum (red) exploits host sterol-rich membrane microdomains (green) to damage and escape from its phagosome

Huge shoutout to @angieprrt.bsky.social and Cristina Bosmani for their very elegant work! 👏
www.science.org/doi/10.1126/...

Stay tuned in the coming weeks to learn more about Angélique's work 👀

🏆 It's a double win for the Soldati Lab! Last Friday, our former PhD students @angieprrt.bsky.social and Jahn Nitschke each received an award for their doctoral work: the Laemmli Prize for Angélique and Best Thesis in Life Sciences for Jahn. So proud of both for these well-deserved honors! 🤩

🚨 Preprint alert 🚨

Don’t miss our latest story on how mycobacterial surface shedding shapes the host response !

A long journey with a fantastic conclusion! Congrats 🍾🧑‍🎓

🇻🇳 What a great week at the BPHCI Conference in Vietnam! @j-toinon.bsky.social and @angieprrt.bsky.social enjoyed sharing their results on M. marinum–Dicty interactions. A small crowd, but packed with brilliant science and great vibes! 🥂

Inorganic sulfate is critical for Mycobacterium tuberculosis lung tissue colonization and redox balance | PNAS Tuberculosis remains the deadliest infectious disease caused by a single pathogen, highlighting the urgent need for novel therapies. A deeper under...

Excited to share Wendy Le Mouëllic’s PhD work, now published in @pnas.org!
It reveals that M. tuberculosis depends on inorganic sulfate import to survive inside host cells—fueling essential processes such as redox balance and stress resistance.
Huge congrats to Wendy & colleagues!
shorturl.at/WbFQC

🦠 Mycobacteria aren't just tough, they're interior designers! 🦠 Check out our latest #preprint 🚨, led by our PhD student @camimille.bsky.social , where we show that #Mycobacterium tuberculosis builds secret cytoplasmic membranes to adapt its metabolism and sneak past immunity 🤫

Thread coming soon!

Be our new colleague! 🎉
The Dept of Molecular and Cellular Biology at the University of Geneva is hiring an Assistant Professor or Associate Professor.

👉 More details here: lnkd.in/e8Z9eAm4
👉 Our department: mocel.unige.ch

Please feel free to share this opportunity with your network.

YouTube video by Francis Crick Institute Researching the World’s Deadliest Infectious Disease – with Maximiliano Gutierrez

Watch @maxgg.bsky.social, Group Leader at the Crick, as he explains what happens to cells that are infected with tuberculosis and how his lab is studying our bodies’ response to this infection.
www.youtube.com/watch?v=VWCt...

Long live Dicty! ✨
So grateful for the chance to attend this wonderful meeting one last time. Always a joy to reconnect with old colleagues and friends

Mosaic evolution of clathrin-mediated endocytosis in fungi Picco et al. take an evolutionary approach to study clathrin-mediated endocytosis in a fungal clade and discover that the process is evolving in a mosaic fashion. The early phase of endocytosis has sh...

How does evolution shape ancient cellular processes? Our new paper uncovers the mosaic evolution of conserved and diverging endocytic traits in fungi!

www.cell.com/current-biol...

Last week was a fantastic opportunity for @lucasceseti.bsky.social to share his work on Xanthomonas and Dicty at #ETOX25 🦠
The Basque Country was the place to hear great science on toxins🤩

Come and Join our Dpt in Beautiful #Geneva !

We are looking for a #Microscopy & #Image #Analysis expert to help all of us at the Dpt.

Frontiers | Dictyosteliumdiscoideum–Mycobacterium marinum infection model: a powerful high-throughput screening platform for anti-infective compounds Tuberculosis is among the world’s deadliest diseases, causing approximately 2 million deaths annually. The urgent need for new antitubercular drugs has been ...

Check our latest methods chapter on how to use Dictyostelium–Mycobacterium marinum as a high-throughput screening platform for anti-infective compounds 👇

www.frontiersin.org/journals/mic...

@nabilhanna3.bsky.social

Last week’s ESCRT meeting was full of great science and engaging discussions! 🤩
Such a great place to share our work on ESCRT during Mycobacterium marinum infection 🦠

Mycobacterium tuberculosis biology, pathogenicity and interaction with the host Nature Reviews Microbiology - In this Review, Warner, Barczak, Gutierrez and Mizrahi explore essential aspects of Mycobacterium tuberculosis physiology and biology, present recent advances related...

💥 Very excited to share this review in Nature Reviews Microbiology.
Contributing to this review with Val, Digby and Amy was an enlightening experience! Hope people in the community find it useful- we managed to cite around 200 papers...
www.nature.com/articles/s41...
www.nature.com/articles/s41...

The Mycobacterium tuberculosis Transposon Sequencing Database (MtbTnDB): A Large‐Scale Guide to Genetic Conditional Essentiality Mtb transposon sequencing database is a unified resource for exploring conditional gene essentiality in Mycobacterium tuberculosis. By standardizing over 150 transposon sequencing screens, it enables...

Jinich et al. present an important new resource for the Mtb community!
The Mycobacterium tuberculosis Transposon Sequencing Database (MtbTnDB) is an interactive web resource summarizing 150+ published screens.
#MicroSky #Mycobacterium #tuberculosis
onlinelibrary.wiley.com/doi/10.1111/...

A great pleasure to keep the Montpellier connection 😇

Paramoeba atlantica as a Natural Intracellular Niche for Vibrios in Marine Ecosystems Various vibrios can colonise a large vacuole called VCV (Vibrio-containing-vacuole) within Paramoeba atlantica. The VCVs acidify and the vibrios multiply and remain alive inside the VCVs for hours. T....

🚨 Great story released by @gm-charriere.bsky.social and co.!
They identified and characterised a natural interaction between amoebae and Vibrio, pointing to Paramoeba as a potential reservoir of oyster pathogens 🦪
Congrats! 🥂
enviromicro-journals.onlinelibrary.wiley.com/doi/10.1111/...

🥳🙌

What better way to wrap up the Soldati tour than with a fantastic talk from @mel-foulon.bsky.social? 🎤
She enjoyed “shedding” her enthusiasm for Myco lipids with such a brilliant crowd of passionate scientists at #EMBOcellBioHostPath! 🧫✨

Yesterday, @nabilhanna3.bsky.social had the fantastic opportunity to present one of his projects during another vibrant and successful poster session at #EMBOcellBioHostPath! 👏
Stay tuned for @mel-foulon.bsky.social ‘s talk

🤩 Great start to the #EMBOcellBioHostPath!
Justine had the honor of kicking off the Soldati lab presentations with her fantastic poster!
Not too late to catch up if you missed it!
📍Stay tuned for @nabilhanna3.bsky.social poster tomorrow and @mel-foulon.bsky.social talk on Thursday!

Did you know the cell wall of mycobacteria isn’t just for protection? 🧱👀 Here, Mycobacterium marinum sheds its outer capsule right after being eaten by Dicty! A sneaky move that affects even nearby cells… #FluorescenceFriday #Mycobacteria #CellBiology #Infection #3Rmodels #Phagocytosis

It was good to see @carobarisch.bsky.social back in town! Thanks for the career view and advices ✨