Jeff Miner

The defects in the Alport GBM allow plasma proteins to penetrate and become lodged or integrated, and they may interact with cellular receptors. Our data suggest that some of the mesangial matrix proteins in healthy mice come from the blood as well.

Glomerular basement membrane structural integrity dictates trans-tissue deposition of laminin in the kidney Basement membranes (BMs) are specialized extracellular matrices (ECMs) essential for tissue structure and function. In non-vertebrates, ECM components…

Glomerular basement membrane (GBM) structural integrity dictates trans-tissu... www.sciencedirect.com/science/arti... Really proud of this Cell Reports paper showing that the potentially pathogenic laminin alpha2 in the Alport GBM comes not from glomerular cells, but from the bloodstream.

Terrific interview!

Great collaboration! So happy that our O'Brien Kidney Center Variant Validation Core could help out with the VUS analyses. @washunephrology.bsky.social @obrienkidney.bsky.social

I just heard you on the ad for tomorrow’s show!

Your ASN-AHA Young Investigator Award seems like yesterday! Congratulations on the 2-peat!

This makes me very curious about the COL4A5 variant!

Highlights from my talk yesterday on Alport syndrome spectrum of disorders. (since no one posted it, I'll have to do it myself)

Variants in type IV collagen cause a wide spectrum of disease. #KidneyWk 🧵

Thanks to Julie Inglefinger for this enlightening summary at ASN KidneyCure Week!

I’ll be there!

Spreading the word about the Importance and Power of Podocytes at @asnkidney.bsky.social Kidney Week in Houston. @isgd.bsky.social

Thanks to NIDDK for funding this work! #AlportSyndrome @alportuk.bsky.social @alportalliance.bsky.social

Mouse Alport podocytes are susceptible to AAV9 transduction in vivo Alport syndrome features a defective glomerular basement membrane (GBM) due to variants in COL4A3, COL4A4, and COL4A5. The most severe forms, which lack the GBM’s collagen α3α4α5(IV) network, progress...

I first presented the data in this paper at the Philly Podocyte meeting in May 2023 (thanks @ksusztak.bsky.social
& Larry Holzman), and a few days ago the paper appeared in
@kidneyint.bsky.social . Promising results for new ways to treat Alport syndrome. kidney-international.org/article/S008...

I eagerly await the translated version!👏

Structurally beautiful--and beautifully functional, too!

📢 Ready to take your research further? The 2026 KidneyCure Grant cycle is open. Funding, mentorship, and resources are waiting. Applications close on Thursday, November 20, at 2:00 p.m. EST. Programs support fellows, PhD students, and early-career faculty in kidney care: bit.ly/kcgrantsfund...

Congratulations, finally!!

Congratulations Stephen! I look forward to hearing your talk in Baltimore in November at ASMB 2025! @amsocmatbio.bsky.social

This reminds me of early days of email & listservs & out of office autoreplies. Someone on a listserv would have auto replies turned on but no limit of once per address. This caused an endless loop of autoreplies to the listserv, received by all. People replied "take me off" & the cycle continued.

🚨 Final call: The ASN Loan Mitigation Program closes tomorrow, Wednesday, August 20, at 2:00 p.m. EDT. Get your application in for a chance at $50K over three years toward student loans to reduce your debt and focus on your career in kidney care. 👉 bit.ly/lmp2025

Very happy that Kidney News published my call for a kidney care revolution. Thank you to @asnpublications and everyone who has guided me along the way.

Check out my article on Alport syndrome in the July ASN Kidney News: "From Basement Membrane Thinning to Alport Syndrome: An Array of Presentations Caused by COL4A3/A4/A5 Gene Variants" www.kidneynews.org/view/journal...

🗳️ Voting for the ASN Council Election is now open! Select the next Executive Councilor and At-Large Councilor. Your voice helps shape what’s next in kidney care.

Deadline: Friday, September 5, at 11:59 p.m. EDT
🔗https://www.asn-online.org/vote

Collagen IV in Gould syndrome and Alport syndrome Nature Reviews Nephrology - In this Review, the authors focus on the role of collagen IV in Gould syndrome and Alport syndrome. They discuss the molecular and phenotypic similarities and...

Thrilled to have this finally published! If you are interested in learning about the collagen IV diseases Gould syndrome and Alport syndrome, add this to your reading list. www.nature.com/articles/s41...

One of my favorite sessions in Hamburg!

Congratulations Moe!!!

Joshua's story about living with APOL1-associated diasease inspired Dr. Katalin Susztak to present the connecting bridges from mapping to mechanisms to medicine! 💊 More results at the next #PodocyteConference? 🤩

The U.S. Lit a Beacon for Science. Under Trump, Scientists Fear It’s Dimming

Talked to @KateZernike at @nytimes about my journey and the current moment for scientists in the U.S.

“Ardem Patapoutian’s story is not just the American dream, it is the dream of American science.”

Read the article here. No subscription required:

www.nytimes.com/2025/06/03/u...

Just attended a terrific meeting on Alport Syndrome So many talented experts in the room + the most involved patients. And so much hope for progress towards new treatments.

The OKRA National Forum is happening tomorrow from 12-1pm CST / 1-2pm EST!

Dr. Naoka Murakami (WashU) will be discussing “T cells in Kidney Wells: Lessons from Immunotherapy-associated Kidney Injury.”

Learn more and register at our website: www.uab.edu/okra/trainin...