Institute of Molecular Genetics

Today is the global Rare Disease Day 2026 and we together with colleagues from @imgprague.bsky.social want to raise awareness of research on rare diseases #ciliopathy #BardetBiedlSyndrome

🚀Open PhD positions!
⏳Time is running fast.
👋We are looking for you.
🧡APPLY NOW img.cas.cz/phd

🚀Open PhD position!
🩸Dissect the molecular mechanisms that enables balancing immune responsiveness with self-preservation in hematopoesis.
We seek a PhD candidate for our supporting environment in a state-of-the-art institution.
🧡APPLY NOW img.cas.cz/phd

🚀Open PhD positions!
🧬We currently seek motivated PhD candidates for our projects at IMG.
You may join Subhadip in a friendly, supportive and international Lab of Developmental Mechanobiology
🧡APPLY NOW img.cas.cz/phd

🚀Open PhD position!
Lab of Integrative Biology is seeking a new talent.
💪Ultimate goal: Provide mechanistic insight into cytoskeletal targeting strategies in cancer and support the development of plectin-directed therapies.
🧡APPLY NOW img.cas.cz/phd

🚀Open PhD position!
Join our newly established Lab of Immunophysiology.
👉How lymphoid and myeloid immune cells communicate to maintain homeostasis and respond to infection. Use mouse models, single-cell RNA seq, and genetic screens to uncover the regulatory pathways.
🧡APPLY NOW img.cas.cz/phd

🚀Open PhD position!
Lactation requires tightly coordinated DNA replication, transcription, and DNA damage responses to sustain milk production. This PhD project will uncover the molecular mechanisms driving these processes in mammary epithelial cells.
🧡APPLY NOW img.cas.cz/phd

🚀Open PhD position!
This project studies how primary cilium structure shapes its function and transport🦠, using advanced imaging to uncover mechanisms underlying ciliopathies🔬
Laboratory of Cell Motility is seeking a candidate with a deep interest in cilia biology
🧡APPLY NOW img.cas.cz/phd

We would like to invite you to celebrations of the Rare Disease Day organized by @czphenogenomics.bsky.social ⤵

Prague became my 2nd home, says Mehak about her PhD transition.
Read the full interview ➡ www.img.cas.cz/2026/02/8964...

Do you wish to join us in one of the safest cities in the world?
🧡APPLY NOW img.cas.cz/phd

🚀Open PhD position!
Combine bioinformatics, single-cell and spatial multi-omics, with machine learning to uncover how the vertebrate head evolved.
🧫Laboratory of Transcriptional Regulation is seeking a highly motivated PhD candidate.
Come and join us
🧡APPLY NOW img.cas.cz/phd

🚀Open PhD position!
Genome instability promotes cancer development. This project will examine metabolic signaling defects to reveal cell vulnerabilities and novel chemotherapeutics.
🧬Laboratory of Cancer Cell Biology is seeking a new team player.
Do you fit?
🧡APPLY NOW img.cas.cz/phd

🚀Open PhD position!
Join Nenad at IMG and share with us:
💛Experience
🧡Friendship
💙Professionalism
💜PhD community

APPLY NOW: img.cas.cz/phd

🚀Open PhD position!
Ever wondered how cells polarize during early development?
This PhD project dives into how mechanochemically-driven cell polarization evolves.
🧪 Genomics
🔬 Biophysics
📊 Fitness analysis
Hooked?
🧡APPLY NOW img.cas.cz/phd

🚀Open PhD position!
Join our newly established Lab of Immunophysiology.
🧪How do lymph nodes maintain immune tolerance? We‘ll study how fibroblastic reticular cells present self-antigens to support Treg maintenance and prevent autoimmunity.
👉Do you know lab work and coding?
🧡APPLY NOW img.cas.cz/phd

Joining IMG was the right choice 🎉
Read the full interview with our PhD student Kristína Jamrichová www.img.cas.cz/2025/02/8515...

Be like Kristína, join us now!
APPLY HERE img.cas.cz/phd

🚀Open PhD position!
Lab of Cell and Developmental Biology is seeking a new team player.
🤝Join us to study stem cells, DNA repair, and how 💥cancer💥 really starts.
👉We seek independent thinker ready to learn both experimental and computational approaches.
🧡APPLY NOW img.cas.cz/phd

Join the Laboratory of Haematooncology and study chronic inflammation, aging and blood stem cells🩸
👩‍🔬👨‍🔬We seek a highly motivated, enthusiastic and hard-working PhD student with a strong team spirit
🤝We offer a friendly and supportive environment in a state-of-the-art institution
APPLY: img.cas.cz/phd

Rps19R67∆ mutation creates a model of Diamond–Blackfan anemia and reveals downstream mediators of p53 pathway Diamond–Blackfan anemia (DBA) is a rare bone marrow failure syndrome accompanied by cardiovascular, skeletal, and urogenital abnormalities. Most of the affected individuals carry mutations in ribosom...

Hope for rare anemia patients: Czech scientists create "perfect" mouse model

Researchers from @czphenogenomics.bsky.social @imgprague.bsky.social achieved a breakthrough in understanding Diamond-Blackfan anemia, a severe genetic disease causing anemia and birth defects in children.

bit.ly/4r4dg6I

💪PhD at IMG is always a good choice.
Join @sindija.s, our student representative, and start enjoying what IMG offers.
🧡PhD Conference, Career Day, Green Swap and much more - come and see!
Wanna help Sindi organizing PhD events?
APPLY NOW ➡ img.cas.cz/phd

🚀Open PhD position!
Lab of Integrative Biology @gregorlab.bsky.social is seeking a new talent.
💪Ultimate goal: Develop AAV-compatible mini-plectins to treat muscular dystrophy and cardiomyopathy
👉Profile: MSc, interest in biology, motivation, independence
🧡APPLY: img.cas.cz/phd

🤝Join us in Prague!
Browse our open PhD positions at www.img.cas.cz/phd
Join a global team and supportive environment, work with top-notch facilities, and enjoy our IMG community!
➡APPLY NOW!

🚀CALL for PhDs just launched🚀
We are accepting applications for the PhD program
🚨APPLY NOW!🚨
📅28. 2. 2026
➡www.img.cas.cz/phd

Imbalance of stem-like and effector T cell states in children with early type 1 diabetes across conventional and regulatory subsets - PubMed Type 1 diabetes (T1D) is an autoimmune disease caused by the loss of self-tolerance toward insulin-producing pancreatic β-cells. Its etiology remains incompletely understood but involves dysregulated T cell responses. Here, we perform single-cell transcriptomic analysis of peripheral blood T cells f …

Publication pubmed.ncbi.nlm.nih.gov/41381478/

Press release (in Czech) www.img.cas.cz/2026/01/8901...

🎉Publication in Nature Communications!🎉

The immune system at diagnosis in type 1 diabetes in children isn’t overactive, it’s immature🧒

Veronika Niederlova @vercanie.bsky.social and her colleagues showed that key immune cells fail to fully develop, allowing autoimmunity to arise⚖️

Imbalance of stem-like and effector T cell states in children with early type 1 diabetes across conventional and regulatory subsets Nature Communications - Dysregulation of the T cell compartment is a driving factor in the development of Type 1 diabetes (T1D). Here, the authors present a single-cell gene expression analysis of...

Our paper on #tcells in Type 1 #Diabetes is now out in @natcomms.nature.com 👩‍🔬 rdcu.be/eXEH6
T cells in T1D show higher stem-like signatures and signs of Treg dysfunction. Thanks all the collaborators! @imgprague.bsky.social

Contractile fibroblasts form a transient niche for the branching mammary epithelium - Nature Communications Fibroblasts represent a heterogenous cell population but how their differences reflect their plasticity and origin is not fully understood. Here, the authors map the origin and fate of a transient con...

Read the full story ➡
www.nature.com/articles/s41...

🎉New publication in NatCom!
@sumbalovakoledova.bsky.social and her colleagues identified specialized contractile fibroblasts that actively guide growth and branching of the mammary gland during puberty.
👉These cells are temporary – once their job is done, they transform into other cell types.

PF 2026 🧡💙

Merry and scientifically peaceful Christmas!
✨🧬We wish you lovely holidays, minimal cellular stress, stable DNA, functional RNA, well-tempered reactions, and lots of joy not only in the laboratory.
🧡💙Thank you for being with us. And we look forward to another year full of discoveries.