Prof Malú Gámez Tansey

HOO HOO HOOSIERS!!!!!

Thank you for amplifying Mackenzie Bolen’s work 🤓🤩😎💪🏼

Spatial single-cell multiomics from @malutansey.bsky.social & colleagues reveals peripheral immune dysfunction in #Parkinsons & inflammatory bowel disease; "Findings suggest iron mishandling along the gut barrier likely contributes to systemic inflammation"
www.nature.com/articles/s41...

Wrapping up #CTAD2025 in #SanDiego today and it’s back to winter in #Indy 😍😎🤩

The weather and the science were both stellar at #CTAD2025 in #SanDiego

Lots of #sciencerockstar sightings at #CTAD2025

It’s been an incredibly exciting and productive week at #CTAD2025 in sunny #SanDiego

New paper (involving @malutansey.bsky.social et al) explores how LRRK2, GCase, & Cathepsin are affected in primary immune cells from #Parkinsons patients after stimulation with cytokine IFN-γ; LRRK2 levels, Rab10 phosphorylation, & cathepsin activity = largest effect
www.nature.com/articles/s41...

Thank you for highlighting our work in collaboration with @dzamkolab

New paper from @malutansey.bsky.social et al reports that #Parkinsons -linked LRRK2 & GBA1 variants converge on peripheral blood immune cell dysregulation; LRRK2 inhibitors & GCase activators modulate ex vivo response to bacterial exposure
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...

A fantastic day attending thr Midwest/Great Lakes Undergraduate Research Symposium at Oberlin College. So many talented researchers with a bright future ahead. @btlamb.bsky.social, @malutansey.bsky.social #goteamstark

Parkinson's‐Linked LRRK2 and GBA1 Mutations Modulate the Peripheral Immune Response to Pseudomonas aeruginosa Background Peripheral disease mechanisms such as immune dysregulation may contribute to Parkinson's disease (PD). To investigate interactions between common PD mutations and immune responses to envi.....

Excited and proud to share this publication from Julian Mark #TanseyLab3ptO MDPhD at Univ of Florida and team including his lab mentor Rebecca Wallings in collaboration Dzamko lab at Univ of Sydney and Garrido lab in Barcelona funded by MJFF
doi.org/10.1002/mds....

Great tag team #SNRI SEMINAR @iusm by Phil Popovich and Dana McTigue from The Ohio State

Key Milestone in ACTIVATE Phase 2 Clinical Trial of BIA 28-6156 Key Milestone in ACTIVATE Phase 2 Clinical Trial of BIA 28-6156

Bial provide an update on their Phase 2 "ACTIVATE" study (NCT05819359), evaluating the efficacy, safety, tolerability, PK/PD of their GCase activator BIA 28-6156 in 273 genetically confirmed GBA1-associated #Parkinsons patients; LPLV=April 2026
www.bial.com/en/media/new...

WPC Vice-President, Professor @malutansey.bsky.social shares about the Fuel the Future of #Parkinsons Science campaign to support early-career researchers by providing travel grants to attend the 7th World Parkinson Congress #wpc2026 in May 2026 in #Phoenix.

Support -> wpc2026.org/supportresea...

Thank you Stephen Curry for your leadership on this exciting blog post and collaborative publication in @PLOSBIOLOGY on ending #publicationbias written after a workshop hosted by The National Institutes of Health. occamstypewriter.org/scurry/2025/...

Incredibly impressed during the VIB-Ghent Center for Inflammation Research site visit. Congrats to its Director Bart Lambrecht and the entire team 🤓🧠💪🏼

New review from @malutansey.bsky.social & colleagues explores iron mishandling in the brain & periphery in #Parkinsons, & proposes that iron dysregulation outside the brain is an important catalyst that may represent a prodromal mechanistic link in gut-first PD
www.nature.com/articles/s41...

Great visit to the IU Gill Institute for Neuroscience in Bloomington 🤓🤩 hosted by Hui-Chen Lu

It’s important to focus on our own sphere of influence in these challenging times so thank you #ALZIN Indiana chapter of @alzassociation.bsky.social for hosting Cocktails & Conversation at #LiterHouse

Thank you Josh Kulas for the excellent tour of the #IndianaBiosciencesResearchInstitute #IBRI. Looking forward to collaborating with you on #neuroimmunology studies in the #neuroinflammation & #neurodegeneration space 🤓💪🏼🧠🤩 l

Iron mishandling in the brain and periphery in Parkinson’s disease - npj Parkinson's Disease npj Parkinson's Disease - Iron mishandling in the brain and periphery in Parkinson’s disease

Excited to share this review from Mackenzie Bolen Kelly Menees, PhD and University of Florida UG Aidan Dupreez in #TanseyLab3ptO on #irondysregulation in the #brain and #periphery in #Parkinsons. www.nature.com/articles/s41...

If you missed it here’s the video link

www.youtube.com/watch?v=CQM6...

Women with Down syndrome may develop Alzheimer's disease more rapidly than men UC Irvine study finds sex differences may impact treatment approaches

Women with Down syndrome may develop Alzheimer's disease more rapidly than men news.uci.edu/2025/08/12/w... by @ucirvine.bsky.social

#Alzheimers #dementia #DownSyndrome #WomensHealth @elizabethhead.bsky.social

Thank you for amplifying this @leadcoalition.bsky.social 🤓

Sharing an Op Ed that came out this morning in @rcscience.bsky.social

Please join me for this #Debate on Monday Aug 11 at noon Eastern w my colleague Alberto Espay on the role of #proteinopathies in #neurodegenerativediseases Indiana University School of Medicine #NeurologyGrandRounds Zoom link in QR code
lnkd.in/eFAFXNgC

Meeting ID: 831 3389 0773
Password: 653209

Please join me for this #Debate on Monday Aug 11 at noon Eastern w my colleague Alberto Espay on the role of #proteinopathies in #neurodegenerativediseases Indiana University School of Medicine #NeurologyGrandRounds Zoom link in QR code
lnkd.in/eFAFXNgC

Meeting ID: 831 3389 0773
Password: 653209

It’s a wrap in #Toronto for @alzassociation.bsky.social #AAIC25 🤓. See you in #London for #AAIC26 😎💜🧠

Exciting topline results from a #Phase2 trial in #Alz presented at #AAIC25 by #INmuneBio showing #solTNFinhibition by #XPro1595 in amyloid positive patients with 2+ biomarkers of inflammation in blood slowed cognitive decline in a 6 mo trial 🤓💪🏼💜🧠