HNF1A and A1CF coordinate a beta cell transcription-splicing axis that is disrupted in type 2 diabetes
Bernardo et al. uncover a transcription-splicing regulatory axis driven by HNF1A and
A1CF in pancreatic ฮฒ cells. Targeted perturbations, single-cell studies, and human
genetic evidence demonstrate tha...
An HNF1A-A1CF transcription splicing axis regulates insulin secretion, and breaks down in T2D.
Amazing work led by Edgar Bernardo + Matias de Vas + major contributions from Diego Balboa, Silvia Bonas, Mirabai Cuenca, Fanny Mollandin, Merce Planas, Miquel Torrent, MA Maestro and many others
06.08.2025 20:14 โ ๐ 6 ๐ 1 ๐ฌ 0 ๐ 0
Happy to announce that HPAP now has some 180 human pancreatic analyzed by highly multiplexed CODEX analysis. Thanks to Dr. Powers and the whole HPAP team! Here is the link to the experiment data download page: hpap.pmacs.upenn.edu/explore/down...
๐งช
30.06.2025 19:21 โ ๐ 5 ๐ 2 ๐ฌ 0 ๐ 0
@saramostafavi.bsky.social (@Genentech) & I (@Stanford) r excited to announce co-advised postdoc positions for candidates with deep expertise in ML for bio (especially sequence to function models, causal perturbational models & single cell models). See details below. Pls RT 1/
19.06.2025 20:55 โ ๐ 55 ๐ 40 ๐ฌ 1 ๐ 3
our work on the molecular differences between transcription factor isoforms is out now in Molecular Cell!
key point: 2/3rds of TF isos differ in properties like DNA binding & transcriptional activity
many are "negative regulators" & misexpressed in cancer
www.sciencedirect.com/science/arti...
26.03.2025 17:10 โ ๐ 159 ๐ 70 ๐ฌ 7 ๐ 5
Still time to apply!
Applications from US welcome โ four years can feel longer or shorter depending on where you are ๐
02.02.2025 20:18 โ ๐ 13 ๐ 13 ๐ฌ 0 ๐ 0
โชMSCA fellow at @crg.euโฌ w/M. Dias and @jonnyfrazer.bsky.social
> Biological Physics | Proteins | Comp Bio | ML
https://scholar.google.com/citations?user=n55NtEsAAAAJ&hl=en
Director of bioinformatics at AstraZeneca. subscribe to my youtube channel @chatomics. On my way to helping 1 million people learn bioinformatics. Educator, Biotech, single cell. Also talks about leadership.
tommytang.bio.link
Pediatric Hematologist/Oncologist, Geneticist, Stem Cell Biologist
bloodgenes.org
The Bluesky account for Magdalen College, Oxford. Sharing news, events, and providing an insight into College life.
The official account of the Clinical Epidemiology Group at the Institute of Epidemiology and Social Medicine at @uni-muenster.de
Our website: https://clinicalepi.de
Human geneticist ๐งฌ, bioinformagician ๐ง๐ปโโ๏ธ, choral musician ๐ผ, and unrepentant city slicker ๐๏ธ. Amplifying interesting signals (like #ScienceWin)! [he/him]
https://orcid.org/0000-0003-3466-1846
Physician-scientist leading a lab @lmumuenchen.bsky.social, visiting scientist
@broadinstitute.org | Writing about genetics, omics, deep phenotyping, precision medicine
https://www.deepvasc.com/
Associate Professor of CS @ University of Maryland. Proud Rust advocate! I โฅ science & compiled, statically-typed programming languages! Views are my own. Tech stack: https://github.com/rob-p/tech-stack.
Professor of Genetics, UPenn. Diabetes and organ development. Member of the Human Pancreas Analysis Program.
AI/ML for early drug target discovery and precision medicine, with a focus on (epi-)genetics. Lead Scientist at Novo Nordisk, London.
Human genetics and genomics in drug discovery.
Associate Professor, Icahn School of Medicine at Mount Sinai | @Gates_Cambridge Alum | Previously: @Cambridge_Uni | @broadinstitute, @harvardmed |@DrexelUniv.
Genetics and omics of neurodegeneration in Mount Sinai, NYC. www.humphreylab.org
Dedicated to drug discovery, enthralled by science. 5 kids. She. SAB Recursion. Founder SyzOnc. Lab at Broad Institute. Opinions my own.
Professor. CRC. University of Alberta. University of Michigan. Diabetes. Biobanking. Cells, tissues, data. HumanIslets.com, IsletCore.ca, bcell.org
The Mann Lab is a pioneer in mass spectrometry-based proteomics. Posts represent personal views from lab members and Matthias Mann
postdoc with Mark Daly at Broad Institute & MGH - curious about (large) chromosome alterations & (deep) human pedigrees + immunity, cancer & their interplay :)
DNA samples and extensive health records of 20% of the adult population of Estonia (212,000 individuals), applied in 100s of international research projects.
www.biobank.ee
Solve Biology
Head of Generative Genomics, Wellcome Sanger Institute, Cambridge, UK
Systems + Synthetic Biology, CRG, Barcelona
http://barcelonacollaboratorium.com http://allox.bio https://www.sanger.ac.uk/programme/generative-and-synthetic-genomics/
