Emily Liman

The molecular basis of force selectivity by PIEZO2 - Nature PIEZO2 is intrinsically more rigid than PIEZO1, and disparate mechanical stimuli paradoxically evoke opposite conformational and gating responses in each channel.

Very excited to share our new manuscript – published today!

Why are PIEZO1 and PIEZO2 are tuned to transduce different types of mechanical force? I was lucky to work with some extraordinary colleagues to begin to figure out why.

www.nature.com/articles/s41...

An overview of the results below ⬇️ ⬇️

The molecular basis of force selectivity by PIEZO2 - Nature PIEZO2 is intrinsically more rigid than PIEZO1, and disparate mechanical stimuli paradoxically evoke opposite conformational and gating responses in each channel.

So proud of my lab mate @ericmulhall.bsky.social and honored to help with this amazing project he led using MINFLUX to study why PIEZO2 behaves differently than PIEZO1 from the lab of @ardemp.bskyverified.social share.google/2Uln5O5OyqhM...

This is the SAVE Act that Trump is discussing tonight.

Bye for now! Enjoy your offline sabbatical, and feel free to reach out by other avenues...

"I realised that I could not possibly adjust to a feminine role as conceived by my father" RITA LEVI-MONTALCINI Nobel Prize in Physiology or Medicine 1986 Born in Turin, Italy, in 1909, Rita Levi-Montalcini was raised by an authoritarian father who strongly disapproved of women's education beyond finishing school. His attitude was both a hindrance and a spur to Levi-Montalcini's ambitions. She convinced him to let her study medicine. Woefully undereducated to that point, she crammed years' worth of Greek, Latin and mathematics into eight months, and then entered medical school at the University of Turin. Levi-Montalcini went on to become a neuroembryologist who co-discovered nerve growth factor, a prominent figure in Italian politics, and an active researcher and mentor until her death at the age of 103. In 1986 she was awarded the medicine prize.

Rita Levi-Montalcini was raised by a strict father who disapproved of women in higher ed.

She convinced him to let her study medicine.

She went on to co-discover the Nerve Growth Factor. She received the Nobel Prize in 1986.

She was another immigrant that gifted the US with pioneering work.
🧪

I’ve never met anyone that would be better for this job. We need more scientists in congress!

Excited to co-host this conference with @marissascavuzzo.bsky.social and Steve Liberles focused on the peripheral nervous system -- No Brainer! Check out the amazing list of speakers and apply for one of the spots for this small, interactive meeting on the beautiful Janelia Campus at HHMI.

News from central Jersey: I'm running to represent New Jersey's 12th Congressional District.

By entering the fray, I hope to bring ideas of repairing our frayed republic. Not only to defend it in 2026, but to build something stronger, for generations to come!

samwang.substack.com/p/entering-t...

a close up of a brown surface with a few spots ALT: a close up of a brown surface with a few spots

The appropriations bill that includes NIH is being finalized.

The Senate bill includes a bipartisan amendment from Senators Capito (WV) and Baldwin (WI) limiting multi-year funding of grants.

The House version does not and OMB has issued a veto threat if the House includes such language.

1/3

UPenn faculty condemn Trump administration’s demand for ‘lists of Jews’ Groups say EEOC demand for names and personal details echoes dark history and threatens safety and civil rights

HEY WAKE UP.

www.theguardian.com/us-news/2026...

Why are women more likely to get irritable bowel syndrome? New study provides clues Cells in the guts of female mice respond to estrogen by increasing pain signaling, researchers find

Of the hundreds of millions of people living with IBS worldwide, about two-thirds are women.

Now, researchers have identified a biological pathway in the guts of mice that may help explain this disproportionate toll—a finding that could one day lead to new treatments. https://scim.ag/3YD8H78

Thanks for sharing. Heartbreaking - and so senseless.

a close up of a white axolotl with pink ears standing on a rock . ALT: a close up of a white axolotl with pink ears standing on a rock .

Axolotls are famous for regenerating limbs. Turns out they can also regenerate their thymus—and that may show us how to someday to the same. That story and more of the best from @science.org and science in this edition of #ScienceAdviser: www.science.org/content/arti... 🧪

Congratulations! Check it out - very cool work! (and beautiful image!).

Great story by @carlzimmer.com in @nytimes.com that nicely conveys the excitement for the emerging field of interoception. @dulaclab.bsky.social and others are featured, including my tattoo 😳!

Gift article link: www.nytimes.com/2025/11/25/s...

Application review launches on December 1, 2025. We want to read *your* application outlining a vision for a research program deciphering how membrane proteins collaborate to enable cell function, their biosynthesis, and the biophysics and structure of how membrane proteins change shape.

How to Change a Memory: One Neuroscientist’s Quest to Alter the Past Buy How to Change a Memory: One Neuroscientist’s Quest to Alter the Past on Amazon.com ✓ FREE SHIPPING on qualified orders

Good morning everyone!
So, I wrote a book (!!) and it’s coming out November 4th in physical and audiobook form. It’s called *How to Change a Memory*

www.amazon.com/How-Change-M...

Goodbye to Focused Protection. Jay Bhattacharya’s Latest 1-Page Pandemic “Plan” is for Vulnerable People to Stop Being Vulnerable. Jay Bhattacharya's new "plan" is really an admission that if there's a new pandemic, he’s not competent enough to do any of the incredible things he “would have” done regarding COVID. He's not

Bhattacharya's newest 1-page pandemic plan forcefully rejects the GBD, his previous 1-page pandemic plan.

It's really just an admission that he's not competent enough to control a virus and not caring enough to even try.

My latest devastating takedown.

sciencebasedmedicine.org/bhattacharya...

Assistant Professor in Biology and Neuroscience Program - Waltham, Massachusetts (US) job with Brandeis University | 12848464 The Department of Biology and the Program in Neuroscience at Brandeis University invite applications for a tenure-track Assistant Professor positio...

Re-upping this - Neuropeeps! We have a TT Job in my wonderful department at Brandeis! First consideration to applications received by Dec 15 (but why wait?)

www.nature.com/naturecareer...

FERAL: A Video-Understanding System for Direct Video-to-Behavior Mapping Animal behavior unfolds continuously in time, yet quantitative analyses often require segmenting it into discrete, interpretable states. Although manual annotation can achieve this, it remains slow, s...

Our preprint is out! www.biorxiv.org/content/10.1...
Peter Skovorodnikov and I are excited to present FERAL: a new video-understanding toolkit that maps raw video directly to behavior, no pose estimation required.
It works across species, from lab to field, and even in collective systems. (🧵1/n)

Even Nobel Prize Winners Deal With Imposter Syndrome Neuroscientist Ardem Patapoutian immigrated to the US, found belonging in science, and did groundbreaking work on sense of touch.

"Even Nobel Prize Winners Deal With Imposter Syndrome": Check this out @scifri.bsky.social: www.sciencefriday.com/segments/ard...

Dr. Florence Sabin | Immunologist and educator, born #OTD in 1871.

The first woman to hold a full professorship at Johns Hopkins School of Medicine (where she graduated from in 1900) and the first woman elected to the National Academy of Sciences. #WomenInSTEM

A child's drawing of a female scientist, with the text: What does a scientist look like? Children are drawing women more than ever before

When asked to draw a scientist, school-age kids in the United States are increasingly sketching women, according to a study from 2018.

Read more on #STEMSTEAMDay: https://scim.ag/4qFrPON

Excited to share our latest @nature.com: How does naloxone (Narcan) stop an opioid overdose? We determined the first GDP-bound μ-opioid receptor–G protein structures and found naloxone traps a novel "latent” state, preventing GDP release and G protein activation.💊🧪 🧵👇 www.nature.com/articles/s41...

YouTube video by PBS NewsHour Top researchers consider leaving U.S. amid funding cuts: 'The science world is ending'

The United States was the leading destination for top scientists from all over the world.

That is ending. Politicians ended it. It will cripple our future competitiveness.

And it’s such a bitter tragedy. Almost no Americans, Conservative or Liberal, grasp what is now being stolen from them.

Thank you!

Plot twist - CryoEM reveals that inhibitors bind to a different site (actually two sites). May displace cholesterol? The discovery of a druggable site will enable the identification of inhibitors and activators of other OTOP channels and propel research into their diverse physiological functions.

2x screens -> good, high affinity inhibitors.

Structure-guided discovery of Otopetrin 1 inhibitors reveals druggable binding sites at the intrasubunit interface Nature Communications - Otopetrins form proton channels in animals ranging from nematodes to humans. Here, authors identify small molecule inhibitors and characterize their binding in the...

Excited to report the identification of small molecule inhibitors of OTOP1 and their binding sites. Congratulations to first authors Batuuji Burendei from Ward/Forli labs at TSRI and Josh Kaplan for great team work! rdcu.be/eMpV9