Approach to Heterospirocycles for Medicinal Chemistry The gold(I)-catalyzed cycloisomerization of aliphatic 1-bromoalkynes has been applied to the synthesis of heterospirocycles. The reactivity of the C(sp2)–Br bond in the products allowed for further derivatization of the obtained scaffolds. In this way, spiroheterocycles decorated with a plethora of functional groups (i.e., CO2H, NH2, OH, and Bpin) were readily obtained. These spirocyclic compounds are valuable building blocks for modern drug discovery projects.

Excited to try out Bluesky! Kicking things off by sharing my latest publication: Synthesis of heterospirocyclic compounds through cycloisomerization of 1-bromoalkynes under gold(I) catalysis. In collaboration with P. Mykhailiuk and collaborators.
pubs.acs.org/doi/full/10....

18.09.2025 15:37 — 👍 1    🔁 0    💬 0    📌 0

Congrats to @fruepp.bsky.social, Vasily Grebennikov, Mykola Avramenko, Marc-Olivier Ebert "Kinetic, Spectroscopic, and Computational Investigation of Oxidative Aminative Alkene Cleavage Reveals an N-Iodonium-Iminoiodinane Pathway" now @chemrxiv.org - chemrxiv.org/engage/chemr...

02.09.2025 19:18 — 👍 14    🔁 6    💬 1    📌 1