Karen Lane

Boundary issues: SWI/SNF shapes chromatin patterns in and around centromeres Abstract. The SWI/SNF family of chromatin remodelling complexes, comprising BAF, PBAF and ncBAF, is known for their critical roles in regulating chromatin

Some Friday reading...new review in Open Biology where we discuss how SWI/SNF maintains the chromatin environment around centromeres, building on recent work from ourselves and others. Lots of fun putting this together with @alison-harrod.bsky.social and @thedownslab.bsky.social!

We are looking for new colleagues to come join us in Galway as group leaders (Junior and Senior). The Centre for Chromosome Biology is a great place and it is a good time to join. Please reach out if you want to chat about the opportunity!
www.nature.com/naturecareer...

Lots more feedback welcome and encouraged in our new manuscripts which we hope to have available on Biorxiv and beyond to all of you, as soon as possible 😊

Then a presentation at the Molecular and cellular biology away day, where we could chat and interact with our peers 😊 A great day!!

Next a presentation at our Institute's annual conference, presenting work from our wonderful lab members Susana and Noa who are on maternity leave and back treating patients in the Marsden, respectively ❤️❤️

First a return to my homeland to reconnect with the many chromatin experts there, as part of the annual Irish Chromatin Consortium 🇮🇪

A busy 6 weeks spreading exciting results from myself and @thedownslab.bsky.social 😊

🤩🤩🤩

Merci David!

PBRM1 null cells have increased whole arm exchanges and DNA recombination at centromeric DNA 🧬 This ultimately leads to a sensitivity of PBRM1 null cells to mitotic perturbation, representing a potential therapeutic sensitivity in PBRM1 mutant cancers 💊

Thanks to lots of proteomics profiling from Theo & the Choudhary lab, we found that PBRM1 loss leads to loss of centromeric protein abundance. PBRM1 null cells also exhibit an altered centromere structure and mislocalisation of pericentromeric heterochromatic marks such as H3K9me3 🔬

PBRM1 directs PBAF to pericentromeres and protects centromere integrity Nature Communications - Centromere fragility can drive tumourigenesis, so protective mechanisms are important. Here, the authors suggest that the PBAF chromatin remodelling complex, which is...

Delighted to share that our paper on the role of PBAF in centromere integrity is out now in @natcomms.bsky.social! It was a long journey but it was made so much easier thanks to my co-first author/coding whiz @alison-harrod.bsky.social, the whole @thedownslab.bsky.social team, & our wonderful boss!

🆕 We're getting in on the act with an ICR research #StarterPack. Check it out! ⤵️

Let us know if you're a #cancer researcher at the ICR and The Royal Marsden but not in the pack. 💬
#CancerResearch #CanSky #OncSky

go.bsky.app/EGXU5V1

Scientific Officer - Epigenetics and Genome Stability in Chelsea | The Institute of Cancer Research View details and apply for this Scientific Officer - Epigenetics and Genome Stability vacancy in Chelsea . Salary : Commencement on the salary range is subject to comparable skills and exp...

We are looking for someone to join our lab as a researcher (scientific officer). Advert and information on applying is here: jobs.icr.ac.uk/vacancies/10...
It's a great team and a wonderful place to work!