Joshua Newson

Dropping out, burning out, tuning out • Andrew Dean Nobody’s happy about the state of Australian universities, but a seasoned academic has some remedies

Many of you in #AcademicBsky in the northern hemisphere might not know the dire state of Australian academia. This essay by Andrew Dean is a fair snapshot of the state of the sector.

Thinking today especially of academics in some Aus unis facing mass job cuts ~ 3,000 jobs on the chopping block now.

13.08.2025 21:55 — 👍 17    🔁 8    💬 2    📌 2

Great week of science in New Hampshire at the Salmonella GRS/GRC. Thanks to the chairs for their hard work. Really nice to see a strong Aussie cohort here too. Looking forward to 2027!

08.08.2025 13:25 — 👍 2    🔁 0    💬 0    📌 0

Excited to be traveling to New Hampshire USA for the GRC Salmonella meeting, looking forward to some great discussion. But, since I'm traveling on Swiss National Day, first a quick farewell Raclette 🇨🇭 🧀 🥂

01.08.2025 14:07 — 👍 1    🔁 0    💬 0    📌 0

Antibiotic-recalcitrant Salmonella exploits post-antibiotic microbiota disruption to achieve virulence-dependent transmission Newson et al. show that antibiotics not only reduce Salmonella infection but also disrupt the gut microbiota, enabling relapse and transmission from tissue-lodged persister reservoirs. Relapse requires intracellular virulence factors and produces clonal populations. Microbiota transfer between hosts blocks pathogen relapse-associated blooms, revealing how the host-pathogen-microbiota axis shapes transmission.

Antibiotic-recalcitrant Salmonella exploits post-antibiotic microbiota disruption to achieve virulence-dependent transmission

17.07.2025 23:23 — 👍 0    🔁 1    💬 0    📌 0

Antibiotic-recalcitrant Salmonella exploits post-antibiotic microbiota disruption to achieve virulence-dependent transmission Newson et al. show that antibiotics not only reduce Salmonella infection but also disrupt the gut microbiota, enabling relapse and transmission from tissue-lodged persister reservoirs. Relapse require...

We're happy to share this example of how antibiotic treatment can promote clonal transmission of an invasive gut pathogen. We also explore the importance of preserving microbiota during treatment. Thanks to everyone who contributed to this paper! #MicroSky #IDSky
www.cell.com/cell-reports...

14.07.2025 09:28 — 👍 4    🔁 0    💬 1    📌 0

Really nice to be back in Australia for a couple of weeks, going through Brisbane, Melbourne, and Adelaide. Nice to trade snow for sunshine and catch up with friends, family, and colleagues around the country 🇦🇺 🍻 🌞

31.12.2024 11:29 — 👍 1    🔁 0    💬 0    📌 0

Here, we use them to ask which effectors are critical for virulence in mouse infection, with a focus on gut pathology and inflammation. We're committed to sharing these strains with anyone who is interested in Salmonella virulence, so please let us know if you would like them

15.12.2024 15:48 — 👍 2    🔁 0    💬 0    📌 0

Salmonella multimutants enable efficient identification of SPI-2 effector protein function in gut inflammation and systemic colonization Salmonella enterica spp. rely on translocation of effector proteins through the SPI-2 encoded type III secretion system (T3SS) to achieve pathogenesis. More than 30 effectors contribute to manipulatio...

Excited to share this story describing new tools for studying Salmonella virulence. We engineered six multimutant strains to be deficient for different sets of SPI-2 T3SS effectors. We think there's lots of potential for new discoveries using these strains www.biorxiv.org/content/10.1...

15.12.2024 15:48 — 👍 23    🔁 9    💬 1    📌 1

Coming to the end of a big week in Liverpool, great to share some of our work on pathogen transmission and antibiotic persistence. Thanks @jayhinton.bsky.social for hosting me at @liverpooluni.bsky.social and thanks to the Microbiology Society for the support to present at #FISHIS24

22.11.2024 12:23 — 👍 16    🔁 3    💬 0    📌 1

Thanks for having me across! Great to meet the team in Liverpool

20.11.2024 14:46 — 👍 1    🔁 0    💬 0    📌 0