Mar Hernández Secorún

Mapping the anatomy of placebo analgesia The identification of somatotopy in brainstem pain modulatory pathways could help treat chronic pain

Thanks to @massih.bsky.social for inviting me to co-author this commentary @science.org Mapping the anatomy of placebo analgesia | Science www.science.org/doi/10.1126/...

A really interesting paper from @drvinkopalada.bsky.social and colleagues for figuring out where to focus our intervention. If my patients mostly have nocturnal symptoms, which one would you use?

Differential Effects of Pregabalin and Morphine on the Sleep-Wake Cycle and Circadian Rhythms in Mice with Neuropathic Pain - PubMed Pregabalin, unlike morphine, restores SNI-disrupted sleep architecture, circadian rhythms, and spinal circadian gene expression.

🎉 Excited to share that our latest research has been accepted for publication in Anesthesiology!

Both #pregabalin and #morphine relieve #pain in mice with #neuropathic pain, but only pregabalin stabilises REM #sleep, sleep #spindles and #circadian #rhythms.

pubmed.ncbi.nlm.nih.gov/40802988/

Very proud that our human PNS atlas is finally published in @natcomms.nature.com We found perineurial hyperplasia and lipid-associated nerve macrophages in #polyneuropathies.
Explore: pns-atlas.mzhlab.com
A tweetorial 1/13
doi.org/10.1038/s414...

This work is finally online as in-press preview!

JCI - Cell and molecular profiles in peripheral nerves shift toward inflammatory phenotypes in diabetic peripheral neuropathy www.jci.org/articles/vie...

Can creativity in science be learnt? These researchers think so Time pressure gets in the way of ideas. Developing ‘creative oases’ and small grants for risky ideas can encourage innovative thinking in science.

Time pressure gets in the way of ideas. Nature Careers spoke with researchers about making space for creativity by developing ‘creative oases’ and small grants for risky ideas to encourage innovative thinking in science. #Academicsky 🧪

Lin et al. find that structural brain alterations are linked to neuropathic pain in peripheral neuropathy, including thinning, gyral flattening, and altered topographic organization in pain-related cortices. Learn more in #PAIN bit.ly/3Hnqzhi

Fig. 1: Identification of cool-sensitive Calb1Trhr neurons in the SDH.

A study in Nature Communications identifies a neural circuit in mice that transmits cool sensation from the skin to the brain, revealing a dedicated pathway for detecting innocuous cool temperatures. go.nature.com/45Brumv 🧪

What do you think Lee et al.’s findings in @natcomms.nature.com of a feedforward amplification circuit for cool sensation, as well as a modality-specific spinal pathway for thermal processing, do for our understanding of thermosensation? bit.ly/3JlS8rS #PRF

How to detect consciousness in people, animals and maybe even AI Insights from human brains could inform how scientists search for awareness in all its possible forms.

A feature in Nature explores how research into developing ways to probe layers of consciousness in the human brain could inform how scientists search for awareness in all its possible forms. 🧪

After completing my PhD, I'm embarked on a new journey of learning and growth. I'm eager to dive into the basic science and solidify my foundation as a future translational researcher. Since July, spending a few months at KU Leuven for that! We are continuing the active search for a PostDoc!

Nuestro último trabajo eBioMedicine Lancet: efectos x ejercicio 🏃🏻‍♀️ en cerebro 🧠 muestran perfil hormético (mejora cognición y neurogénesis si es moderado, inútil si extenuante) causado por cambios en microbiota 🦠 y después de trasplante fecal @CSICdivulga @SENC_ @institutocajal.bsky.social

Llimós-Aubach et al. identify the potassium channel TRESK, which regulates the excitability of specific nonhistaminergic pruriceptors and modulates acute and chronic itch, as a potential target for antipruritic pharmacological compounds. #PAIN bit.ly/3U4kolf

Indeed, the authors stated: 'There was a notable lack of detail regarding how adverse events were measured and classified. Furthermore, the short-term follow-up in many trials, combined with potential under-reporting of adverse events, raised concerns about the data completeness.'

Revisiting the updated NeuPSIG guideline, I’m struck by how often efficacy is isolated from harm. With poor AE reporting and short follow-ups, NNHs fall short. RCTs must improve how harms are measured to truly guide neuropathic pain care. www.thelancet.com/action/showP...

Hi Brooke! Thank you for the initiative! Can I be add for the early career and phd searching postdoc? Thanks ✨

Dear Bsky Friends, physical activity as a central pillar of #lifestyle modification in the management of chronic #musculoskeletal #pain & its effects on pain modulation & #sleep, #stress regulation, #diet & #smoking behavior: tinyurl.com/2ntkuda3

Wrapping up a stage 👩🏽‍🎓

First ever skull from ‘Denisovan’ reveals what ancient people looked like Ancient proteins and calcified dental plaque identify heavy-browed fossil from China as a Denisovan.

It’s the first time a near-complete skull has been definitively linked to the extinct people

https://go.nature.com/4e8cekR

Honoured to present a small part of my PhD on how nerve mechanical interface treatment impacts on nocturnal pain symptoms and sleep quality in pre-surgical CTS patients at EFIC CONGRESS 2025! #EFIC2025 @efic.bsky.social