Bernard Thienpont

Global adoption of extended non-invasive prenatal screening will require large-scale validation, but could transform obstetric care from reactive to preventive, personalised medicine.
Thanks to Kate Stanley and Joris Vermeesch for the collaboration, and @natgenet.nature.com for the opportunity!

Also epigenetic signals are present which predict the risk of preeclampsia, intra-uterine growth retardation, gestational diabetes and preterm birth, as well as pregnancy-related immune-mediated disease. Finally, also viral infections can be gleaned from these analyses.

Expanding the scope of non-invasive prenatal screening Nature Genetics - Cell-free DNA from non-invasive prenatal screening reflects the maternal and fetal genome and epigenome. This Review discusses its analysis for actionable pregnancy complication...

🚨review paper alert: non-invasive prenatal screening (NIPS) traditionally predicts common trisomies.
NIPS data however also contains genetic signal to predict additional complications: malignancies, rare autosomal trisomies confined to the placenta, monogenic disorders and common genetic risks.

Methods and applications for single-cell and spatial multi-omics Nature Reviews Genetics - In this Review, the authors discuss the latest advances in profiling multiple molecular modalities from single cells, including genomic, transcriptomic, epigenomic and...

Methods and applications for single-cell and spatial multi-omics go.nature.com/3GkzmzZ #Review by Katy Vandereyken, Alejandro Sifrim, @bernthie.bsky.social & Thierry Voet
Free to read here: rdcu.be/c6JjL

How often are children genetically unrelated to their presumed fathers? Tackling a touchy subject, genetic detective finds only 1% of European children have unexpected paternity

Honoured to see an article about my research on extra-pair paternity in @science.org. Many thanks to journalist @spoke32.bsky.social for the story and to all colleagues for their quotes!
Hopefully, future visitors to my office will be less surprised by a (reproduction) 17th-century painting...

🚨The final deadline to register for #RNGS25 is this Wednesday, March 5th!🚨

Make sure to register - You don’t want to miss Prof. Bernard Thienpont (@bernthie.bsky.social)'s fascinating talk on improving patient care by using cell-free DNA methylome analysis.🧬

www.vibconferences.be/events/revol...

Review alert - "Modelling and design of transcriptional enhancers" by Seppe and Vasilis 👇

Laboratoriumtechnoloog (Lab technician) Een gevarieerde functie in een boeiende onderzoeksomgeving!

📢 #JobAlert We are looking for a lab technician. You can contribute to various interesting research projects. Apply before 11/03:
kuleuven.be/personeel/jo...

In the most recent episode we talked with @vonmeyennlab.bsky.social from ETH Zürich about his work on the interplay of nutrition, metabolic pathways, and epigenetic regulation. #podcast #epigenetics #chromatin

Listen here: https://buff.ly/4jmwK3j

YouTube video by Epigenetics Otago Predicting ‘male-time’ with the Androgen Clock

Delighted to share our 'Androgen clock' paper in #PNAS ow.ly/Guts50ULghF - the first way to predict long-term androgen exposure using DNA alone. We so much more than the sequence we are born with! Stellar work (and animation - SOUND ON) by Dr Victoria Sugrue youtu.be/GL55yjMalII

Finding new folks to follow: try out this tool. bsky-follow-finder.theo.io

🧬Today is your last chance to submit your research for #RNGS25, the leading European #sequencing conference. Present your work on stage or during the poster sessions.
Submit it before midnight (CET) tonight here: vibbio.tech/40g5N8P #NGS #multiomics #genomics #epigenomics

very elegant approach to in vivo CRISPR screens!

Looking forward to meeting you all in Antwerp!

Are you active in #sequencing and want to show your research to leading researchers? Submit an abstract for #RNGS25: vibbio.tech/4iJMnS0
Present on stage with a poster pitch or during the poster sessions.
The abstract deadline is 15 January 2025.
#ngs #genomics #multiomics #epigenomics #AI #ML