Hallmarks of stem cell aging
Aging disrupts core functions of somatic stem cells throughout the body, leading to
impaired tissue maintenance and repair. We identify five key features of aged stem
cells, highlighting how their dys...
Happy to share our review at Cell Stem Cell as part of their Hallmarks series. As always, a pleasure to work with friends and colleagues Anne Brunet (@brunetlab.bsky.social) and Peggy Goodell(@goodell-lab.bsky.social).
Hallmarks of stem cell aging: Cell Stem Cell www.cell.com/cell-stem-ce...
30.06.2025 11:26 — 👍 11 🔁 5 💬 0 📌 0
It was great to work with the inimitable @brunetlab.bsky.social and Tom Rando on this review of stem cell #aging!
30.06.2025 00:58 — 👍 1 🔁 0 💬 0 📌 0
Thank you so much, Dan! It’s such a huge honor. When I started my lab more than 25 years ago, I never imagined this would be possible. I give enormous credit to being in a fantastic supportive environment and many amazing trainees who did all the hard work.
30.04.2025 23:22 — 👍 1 🔁 0 💬 0 📌 0
Age-related blood condition counteracted with a common diabetes drug
Metformin could reduce people’s risk of certain age-associated blood cancers, but more work is needed to identify who is likely to benefit.
New paper from my lab! Elevated mitochondrial membrane potential is a therapeutic vulnerability in Dnmt3a-mutant clonal hematopoiesis: rdcu.be/eh1Nb Complementary to new work from Steven Chan & @georgevassiliou.bsky.social as described by @goodell-lab.bsky.social: www.nature.com/articles/d41...
16.04.2025 21:02 — 👍 50 🔁 12 💬 1 📌 2
Bluesky
Excited to share the @goodell-lab.bsky.social News&Views on 3 exciting studies by Vassiliou Lab, Chan Lab, and @trowbridgelab.bsky.social in @nature.com and @natcomms.nature.com, showing that #DNMT3A mutant (major driver of Clonal Hematopoiesis) blood cells depend on mitochondrial respiration.
16.04.2025 22:18 — 👍 4 🔁 3 💬 1 📌 0
Thrilled to share our new work on #aging in the murine hematopoietic system! There is a lot here- stem cell numbers, self-renewal rates, mutation rates, mutation signatures, clonal fitness, environmental effects...
06.03.2025 18:12 — 👍 38 🔁 8 💬 1 📌 0
Stem cell scientist interested in hematopoiesis and associated diseases. Single cell proteomics is also pretty cool.
Naxerova lab at @HMSGenetics. We study somatic evolution and cancer genetics.
Associate Professor in Cardiovascular Physiology and Pathophysiology at the University of Southern Denmark
We study how micro-environmental and epigenetic mechanisms drive cancer cells into dormancy. We seek to control this biology to prevent and treat metastasis. https://einsteinmed.edu/faculty/16974/julio-aguirre-ghiso
Cellular senescence geek 🤓
Scientist in MSKCC (nanotechnology, inflammation and cancer)
+Arts enthusiast
(All opinions are my own)
Immunologist
https://linktr.ee/Immunologynotebook
Physician Scientist at DKFZ & NCT Heidelberg
studying 🩸🧬 #epigenomics #DNAmethylation #singleCell #precisiononcology #JMML
www.translational-cancer-epigenomics.de
Professor of Cell Biology/Stem Cell Institute, Medicine and Oncology at Albert Einstein College of Medicine (@einsteinmededu.bsky.social), studying stem cell equilibrium and developing therapeutics for hematological disorders
Assistant Director at DNA Learning Center 🧬
PhD - Molecular and Human Genetics
Postdoc - Cancer Biology and Genetics
Left the lab bench for the classroom in 2018 👩🏻🏫
Research Professor Johns Hopkins University @jhuartssciences.bsky.social @mdc-berlin.bsky.social @mdc-bimsb.bsky.social @neurocure.bsky.social @spp2202.bsky.social
Director, Wellcome Sanger Institute. Decipherer of developmental disorders. Co-founder Congenica. Dad, husband, cyclist, gardener. Views own.
Biomedical research team trying to figure out stem cells and blood cancers. Dad, husband, kids soccer coach, rugby enthusiast, everything Star Wars / Marvel.
Professor of Physiology at Karolinska Institutet - SRP Diabetes & University of Copenhagen - Center for Basic Metabolic Research. Lifelong Athlete. Member of Nobel Assembly, Royal Swedish Academy of Sciences, Keystone Symposia Board, & Past President EASD.
Physician Scientist at MSK. All views expressed here are my own & do not represent my employer. COI:http://bit.ly/2LQCLKe
EVP for the Nature Portfolio, part of Springer Nature. I live in Boston but travel elsewhere. All posts are my own.
Scientist in transit. Meet me @College-de-France Paris🇪🇺 or @Arolla🇨🇭#InHoxWeTrust #GesamtNaturWerk. Et Ce Fut Tout.
Professor in Pediatric Infectious Disease researching effects of infection, inflammation, and the microbiome on hematopoietic stem cells and their progeny. How do infections affect bone marrow and vice versa? Co-Director of BCM MSTP. 🌈
Developmental biologist, geneticist, & reproductive biologist. PhD. Son of an immigrant. Hispanic Filipino American. Endurance athlete.
Scientist. Group leader at the Sanger Institute, Cambridge UK. Somatic mutation and selection in normal tissues, cancer and ageing.
