Matt Parker

No, AlphaFold has not completely solved protein folding Biology is hard. Yes, even for AI.

AlphaFold is great, but contrary to public opinion it has not completely solved the protein folding problem. Much work remains to be done.
clauswilke.substack.com/p/no-alphafo...

Rapid polygenic adaptation in a wild population of ash trees under a novel fungal epidemic Rapid evolution through small shifts in allele frequencies at thousands of loci is a long-standing neo-Darwinian prediction but is hard to characterize in the wild. European ash tree (Fraxinus excelsi...

Carey is a post-doc in my lab working on RNA methylation - but we spend a lot of time talking about ash trees! Today, her PhD work on the population genomics of ash die-back is published in Science www.science.org/doi/10.1126/...

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🚨 My first PhD preprint is out on bioRxiv!
We show how tiny mutations—point mutations and kb-level indels—can shape the massive structure of Arabidopsis centromeres.
📄 Read it here: doi.org/10.1101/2025...
🧵 A short thread 👇

HMMER is the bedrock of genomic annotation globally, and now its funding is terminated for no reason.

@cryptogenomicon.bsky.social is now on bsky:

a society where "bad immigrants" are demonised is a society where no immigrant can truly feel welcome, because aren't we all just one wrong turn or accident away from being unemployed? on disability benefits? unable to care for our children without state help? just no such thing as a safe immigrant

📢 We are hiring! 📢

We are looking for a postdoc to help us work out why mice cannot regenerate the spinal cord but spiny mice *can*.

More info and how to apply: tinyurl.com/4m6yzbef

Get in touch if interested!

RNA xkcd.com/3056

Disruption of the mRNA m6A writer complex triggers autoimmunity in Arabidopsis Distinguishing self from non-self is crucial to direct immune responses against pathogens. Unmodified RNAs stimulate human innate immunity, but RNA modifications suppress this response. mRNA m6A modif...

Cool new study:

Disruption of the mRNA m6A writer complex triggers autoimmunity in Arabidopsis

www.biorxiv.org/content/10.1...

Disruption of the mRNA m6A writer complex triggers autoimmunity in Arabidopsis Distinguishing self from non-self is crucial to direct immune responses against pathogens. Unmodified RNAs stimulate human innate immunity, but RNA modifications suppress this response. mRNA m6A modif...

New preprint from us!
We find that disruption of the mRNA m6A writer complex triggers autoimmunity in Arabidopsis –
www.biorxiv.org/content/10.1...

Disruption of the mRNA m6A writer complex triggers autoimmunity in Arabidopsis Distinguishing self from non-self is crucial to direct immune responses against pathogens. Unmodified RNAs stimulate human innate immunity, but RNA modifications suppress this response. mRNA m6A modif...

Disruption of the mRNA m6A writer complex triggers autoimmunity in Arabidopsis doi.org/10.1101/2025...

Female scientists at MPIPZ

🥳Happy International Day of Women and Girls in Science! 🥳🎉🔬🧪. A special nod to all the inspiring female scientists at @mpipz.bsky.social, shaping the future of #plant science with dedication and passion 🌿🪴Read more 👉: bit.ly/4bc1TmF #womeninscience #womeninSTEM #11Feb

RNA splicing: a split consensus reveals two major 5′ splice site classes | Open Biology The established consensus sequence for human 5′ splice sites masks the presence of two major splice site classes defined by preferential base-pairing potentials with either U5 snRNA loop 1 or the U6 s...

RNA splicing: a split consensus reveals two major 5′ splice site classes royalsocietypublishing.org/doi/full/10....

When asked about knockout vs knockdown, Google AI wonderfully bet-hedges on whether you're interested in genetics or boxing