NikkiCutes

Same!! My two favourite chocolate bars! And Big Turk to round out my top 3.

bsky.app/profile/ston...

Same!

Literally the only brand of toothpaste I’ve used for more than a decade. It cleans so well! I also use their Extreme White in rotation sometimes when I indulge more in teeth standing things like tea or red wine.

Figure 1. EBV infection of gastric epithelial cells impinges several molecular pathways leading to GC. EBV expresses latent membrane proteins-1 and − 2A (LMP1 and LMP2A) to maintain latency and cell proliferation through a positive feedback loop with NF-kB. LMP2A activates DNA methyltransferase 3 beta (DNMT3B) causing genome-wide methylation contributing to gastric cancer (GC). The virus may promote DNA hypermethylation in GC, with phosphatidylinositol-4,5-Bisphosphate 3-kinase Catalytic Subunit alpha (PIK3CA) mutations. These mutations may lead to cell proliferation. Other pathways leading to tumor growth, induced by EBV, are Janus kinase 2 (JAK2) and insulin-like growth factor 2 (IGF2) signaling. EBV-encoded microRNA (miRNA) clusters, including miR-BART-1 and − 2, are highly expressed and promote cell survival and immune evasion. In the tumor immune microenvironment (TIME), B cells infected by EBV were found to deliver exosomes carrying miR-BART-15 to epithelial non-EBV-infected cells. The virus might utilize the same mechanism to deliver miR-BART-15 into gastric epithelial cells to inhibit the activation of the inflammasome nucleotide-binding oligomerization domain, leucine-rich repeat-containing protein 3 (NLRP3), thus mitigating the inflammatory antiviral responses. EBV evades immune recognition by overexpressing the co-inhibitors indoleamine 2,3-dioxygenase 1 (IDO1), Programmed Death-Ligand 1 and 2 (PD-L1 and PD-L2).

Viruses, bacteria and Cancer:
New review shows EBV, H. pylori, and SARS-CoV-2 fuel gut inflammation, disrupt immunity & genes, and raise cancer risk. More reasons to prevent infections.
buff.ly/cpqp7JG

#medsky #IDsky #oncsky 😷🛟🧪

PSA: You need a balanced, NOT 'boosted' immune system! The immune system is complex, and needs to exist in balance and harmony. Turning your immune system too high leads to overstimulation and inflammation. Remember, autoimmune diseases such as rheumatoid arthritis occur when the immune system is overactivated and attacks healthy cells within the body - this is what a 'boosted' immune system looks like. Turning the immune system down leads to more infections. Cancer and autoimmunity are two sides of the same coin - in cancer, the tumor can evade or suppress an attack from the immune system. No supplement or food can 'strengthen' your immune system. The only evidence based ways to have a healthy and balanced immunity are: • proper sleep • preventing infections (wash hands, wear a mask) • getting all your vaccines • reducing/eliminating alcohol, smoking & other substances • minimizing chronic stress • wholesome nutrition & physical exercise unambiquous SCIENCE

You need a balanced, not boosted immune system!

Measles exposure at Calgary International Airport Alberta Health Services is warning the public after someone with a confirmed case of measles was at the Calgary International Airport while infectious.

Alberta Health Services says someone with a confirmed case of measles visited the Calgary International Airport on May 19 #yyc www.ctvnews.ca/calgary/arti...

Why so many people are having strokes in their 20s, 30s and 40s: ‘We’ve never had patients so young’ Dr. Mohammad Anadani has shared some intriguing theories on what’s behind the alarming trend of healthy, 20-somethings having strokes.

We have allowed a multi system vascular virus to spread unchecked for nearly 6 years.

Public health has failed to advise folks of the risk to long term health, or of the fact that there’s no such thing as “mild” COVID.

Yet doctors blame sudden rise in young stroke patients on everything BUT Covid

New Link Connects Herpes to Alzheimer's. Here's What We Know. A new study has found the herpes simplex virus type 1 (HSV-1), which causes cold sores, may be linked to the development of Alzheimer's disease.

The researchers also found people who received antiviral treatment for Herpes (HSV-1) had roughly a 17% lower risk of developing Alzheimer's disease compared to those who were untreated.
www.sciencealert.com/new-link-con...

Derby researchers studied 46 people with Long COVID and found that even mild exercise breaks large microclots into smaller ones, triggering inflammation and possibly worsening symptoms.

Exercise may harm more than help without careful oversight.

www.researchsquare.com/article/rs-6...

Moderna withdraws application for COVID-flu combination vaccine Moderna said on Wednesday it has withdrawn an application seeking approval for its flu and COVID combination vaccine candidate after discussions with the U.S. Food and Drug Administration.

This is absolutely terrible news.

With the shifting regulatory climate (i.e., antivax ratfuckery), Moderna has withdrawn their application for their eagerly anticipated COVID-flu combo vaccine. This vaccine offered better protection than getting each shot separately.

h/t @merz.bsky.social

I have long fine hair as well and my favourite brush has always been this one. The bristle are a little harsh brand new but it softens quickly. My first one lasted me over 20 years before I lost it. www.amazon.ca/ISINIS-Altes...

What Children and Teens May Say: • "I don't feel right, but I don't know how to explain it." • "I'm not tired like sleepy-I'm tired like sick." • "I want to do things, but my body won't let me."

From the pediatric section of @batemanhornecenter.bsky.social’s new Clinical Care Guide to ME/CFS and Long Covid.

The truth is a lot of adults who don’t know they have ME and/or LC say these things too.

If you want to stay hydrated without breaking the seal a Sip Valve is a great addition. Not sure how well it would work with a Flo mask though. A nasal spray like Betadine would add another layer of protection too. And make sure to utilize the air vent to keep air moving around you.

Agreed

Dear Canada: tomorrow is Election Day. This is Mark Carney. Hint, hint.

COVID infection tripled the risk of inflammatory heart diseases and was associated with 68% increased risk of any cardiovascular symptoms in kids with normal hearts.

Study period March 2020 to September 2023. Minimum 6 month followup.

www.nature.com/articles/s41...

Boy, when I listen to Mark Carney talk about his plan for investing in Canada’s economy, for breaking down interprovincial & international barriers, for doubling home building, and for turning Canada into an energy superpower, I’m struck by how clearly he knows what he’s talking about.

Refreshing.

FDA suspends milk quality-control testing program after Trump layoffs Effective Monday, the agency suspends its proficiency testing program for grade ‘A’ raw milk and finished products

I looked into it so that you do not have to have to. What's at stake now that milk quality testing by the FDA is suspended? What does milk quality testing involve by the way?
Should you care? A 🧵
www.theguardian.com/us-news/2025...

Studies across 14 nations show 25% to 30% rate of long COVID Among the 25% of participants in 1 study who said they experienced long-COVID symptoms, 13% reported sleep disorders.

www.cidrap.umn.edu/covid-19/stu...

Poilievre tweet from Jun 2, 2022: Today I introduced a Private Member’s Bill to abolish all current vaccine mandates, and ban any and all future vaccine mandates. Give people back their medical freedom. Let them take back control of their lives. Join before Friday June 3rd: Pierre4PM.ca/Membership

Reminder as we watch measles rates climb in Canada that *this* is Poilievre's attitude towards vaccination during a public health emergency.

MMR vaccination has long been mandated for health care workers.

Would a Poilievre govt ban the MMR mandate in health care during a huge measles outbreak?

𝗔𝗽𝗿𝗶𝗹 𝟮 𝗘𝗱𝗺𝗼𝗻𝘁𝗼𝗻 𝗜𝗻𝘁𝗲𝗿𝗻𝗮𝘁𝗶𝗼𝗻𝗮𝗹 𝗔𝗶𝗿𝗽𝗼𝗿𝘁 1000 Airport Rd, Edmonton, AB Sunwing check-in and international departures area Exposure time: Approx. 7 a.m. –11 a.m. (MST) 𝗦𝘂𝗻𝘄𝗶𝗻𝗴 𝗙𝗹𝗶𝗴𝗵𝘁 𝗡𝗼. 𝟰𝟯𝟴𝟳 From Edmonton International Airport to Cancun Mexico. Exposure time: Approx. 9 a.m. – 2:30 p.m. (MST)

Confirmed cases of measles prompts public alert to potential exposures in the #Edmonton area

www.albertahealthservices.ca/news/Page188...

#Alberta #Measles

“I’m not worried about Long Covid”

Of course you’re not. Most people weren’t worried about it, until it happened to them

This is true of most disabilities. People think they’re the exception. That we’ve done something “wrong”. It’ll be different for them

Disability can & does happen to everyone.

Brainstem Reduction and Deformation in the 4th Ventricle Cerebellar Peduncles in Long COVID Patients: Insights into Neuroinflammatory Sequelae and "Broken Bridge Syndrome" Post-COVID Syndrome (PCS), also known as Long COVID, is characterized by persistent and often debilitating neurological sequelae, including fatigue, cognitive dysfunction, motor deficits, and autonomi...

Hamburg researchers scanned 44 Long COVID patients and found severe shrinkage in key brainstem-cerebellum bridges.

These structural breaks, called “Broken Bridge Syndrome,” may underlie fatigue, motor issues, and autonomic dysfunction.

www.medrxiv.org/content/10.1...

I’ve been part of this community for almost 5 years now and very familiar with your work and posts. If you have stopped making fake profiles to get donations then congrats. I haven’t followed you in years because of all the shady stuff you were doing in the beginning and I will never trust you again

You may want do a little more due diligence in researching the people you profile. For years now Amanda has been known as a scammer and fraud among the Long Covid community because she creates fake online profiles to scam people into giving her money.

Study finds strongest evidence yet that shingles vaccine helps cut dementia risk Older adults in Wales who had the jab were 20% less likely to be diagnosed with dementia that those not vaccinated

goddd the number of things that turn out to be caused (at least partly) by infectious, vaccinatable diseases. apparently some dementia is actually "long chickenpox"?

www.theguardian.com/society/2025...

A natural experiment on the effect of herpes zoster vaccination on dementia - Nature Using a natural experiment that avoids common bias concerns, this study finds that the live-attenuated shingles vaccine reduced the probability of a new dementia diagnosis within a follow-up period of...

The vaccine against Shingles helps protect against dementia, results of a natural experiment, adding to prior evidence
"implications are profound"
New @nature.com
www.nature.com/articles/d41...
nature.com/articles/s41...

Masking discourse is on again and I’ll just say if you see people masking when few others are it’s likely because they’ve determined that for them, in that setting, the benefit of not catching (or spreading) whatever’s going around is worth the cost of masking. It’s rarely more complicated than that

HHS's Office of Long COVID Research and Practice has been DOGEd. Closing this week.