Michael D Kornberg

Shingles vaccination prevents or delays dementia and slows the disease course among those already living with dementia @cellpress.bsky.social
www.cell.com/cell/fulltex...

New preprint from
@gocastelobranco.bsky.social lab!! We use MPRA & scCRISPRi/a to interrogate possible functions of GWAS-identified Multiple sclerosis risk SNPs in iPSC-derived oligodendrocytes.
www.biorxiv.org/content/10.1...

Microglia replacement by peripheral delivery of CSF1R inhibitor-resistant hematopoietic cells Microglia replacement holds great promise for the study and treatment of neurological diseases. We previously achieved high-efficiency replacement by …

📄🚨: Building off a stellar 2023 pub that engineered an hCSF1R variant, Sonia et al. now show how an mCSF1R variant not only confers inhibitor resistance and allows for efficient & non-toxic microglia replacement, but does so after vascular delivery into immunocompetent mice! 👏🧠

tinyurl.com/3wvmm8v3

www.researchsquare.com/article/rs-7...

How is the persistence of compartmentalized inflammation sustained in MS?
Our new study in
@cp-immunity.bsky.social
offers some hints.

cell.com/immunity/ful...

Thanks and congratulations to all contributors

At least once per year I see someone with debilitating MS-related tremor, usually cerebellar or rubral. This is a study I was hoping would be done... journals.sagepub.com/doi/10.1177/...

National Academy of Medicine Announces Election of Larner’s Dr. Peter Calabresi as New Member | Office of Medical Communications | The University of Vermont

A #huge win for @uvmvermont.bsky.social www.uvm.edu/larnermed/me...

Anti-BCMA CAR-T therapy in patients with progressive multiple sclerosis Progressive multiple sclerosis (PMS), which is characterized by relentless disease progression, lacks effective treatment. While recent studies have h…

Anti-BCMA CAR-T therapy in patients with progressive multiple sclerosis

www.sciencedirect.com/science/arti...

Immune signatures link myelin oligodendrocyte glycoprotein antibody–associated disease to other autoantibody-mediated conditions Single-cell immunoprofiling uncovered systemic immune cell signatures of neurological MOG antibody–associated disease.

Immune signatures link myelin oligodendrocyte glycoprotein antibody–associated disease to other autoantibody-mediated conditions

www.science.org/doi/10.1126/...

SV2A-PET imaging uncovers cortical synapse loss in multiple sclerosis SV2A-PET reveals cortical synapse loss in multiple sclerosis (MS), highlighting a potential approach for unmasking gray matter pathology.

SV2A-PET imaging uncovers cortical synapse loss in multiple sclerosis | Science Translational Medicine www.science.org/doi/10.1126/...

Notch3+ Treg induced in the gut by microbiota translocate to CNS, outcompete protective NPY1R+-resident Treg, and degenerate into pathogenic Th17 in MS/EAE @cp-immunity.bsky.social @bostonchildrens.bsky.social
www.cell.com/immunity/ful...

2024 MS McDonald criteria now published

www.thelancet.com/journals/lan...

Epstein-Barr Virus in Multiple Sclerosis | Neurology Neuroimmunology & Neuroinflammation Epstein-Barr virus (EBV) is a very common herpesvirus that infects more than 90% of the general population. Epidemiologic data indicate that EBV is a requisite risk factor for the development of multi...

This is a really excellent review of the knowns and unknowns of the role of EBV in MS. Congrats @jsabatino37.bsky.social - this is fantastic www.neurology.org/doi/10.1212/...

Frontiers | Targeting IL-6 receptor mediated metabolic pathways to control Th17 cell differentiation and inflammatory responses Interleukin-6 (IL-6) is a multifunctional cytokine that plays important roles in inflammation. Several studies have shown that IL-6 regulates various aspects...

www.frontiersin.org/journals/imm...

PICALM Alzheimer’s risk allele causes aberrant lipid droplets in microglia @nature.com
www.nature.com/articles/s41...

Frequency and Diagnostic Implications of Paramagnetic Rim Lesions in People Presenting for Diagnosis to a Multiple Sclerosis Clinic | Neurology Background and ObjectivesParamagnetic rim lesions (PRLs) are a well-established imaging biomarker of chronic active multiple sclerosis (MS) lesions. PRLs have been shown to be highly specific for MS (...

www.neurology.org/doi/pdf/10.1...

The emerging role of protein l-lactylation in metabolic regulation and cell signalling - Nature Metabolism In this Perspective, the functions of the recently identified post-translational-modification protein l-lactylation in the regulation of cellular metabolism and signalling are discussed, highlighting the potential of l-lactylation as a therapeutic target.

#Throwback 🧪

PERSPECTIVE | The emerging role of protein l-lactylation in metabolic regulation and cell signalling

H Ren, Y Tang & D Zhang

Emerging connections between myelin and Alzheimer’s disease - Nature Cell Biology Recent literature has explored the contributions of oligodendrocytes and myelin dysfunction to Alzheimer’s disease. Here, we discuss emerging evidence that oligodendrocytes may directly contribute to ...

Emerging connections between myelin and Alzheimer’s disease

www.nature.com/articles/s41...

B-cell antigen presentation in central nervous system autoimmunity The role of B cells in central nervous system (CNS) autoimmunity was initially highlighted by successful clinical trials of anti-CD20 monoclonal antib…

New review from Carson Moseley and Scott Zamvil on B cell antigen presentation in CNS autoimmunity

www.sciencedirect.com/science/arti...

The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis Inflammation, aberrant proteostasis, and energy depletion are hallmarks of neurodegenerative diseases such as multiple sclerosis (MS). However, the in…

www.sciencedirect.com/science/arti...

Targeting cytokine networks in neuroinflammatory diseases - Nature Reviews Drug Discovery Dysregulated cytokine networks are important in the pathogenesis of neuroinflammation. This Review discusses targeting cytokines and their receptors in non-infectious central nervous system inflammato...

Dysregulated cytokine networks have an important role in neuroinflammatory diseases such as multiple sclerosis. Read about progress and challenges in targeting these networks therapeutically in this review
www.nature.com/articles/s41...
rdcu.be/eBzvu

Systematic characterization of cell type-specific master metabolic regulators in Alzheimer's disease

I'm somehow just seeing this now, Lindsay. Words are insufficient - I'm so sorry you're bearing the brunt of this nonsense, and I'm here to help if there's anything I can do

Exoproteome of calorie-restricted humans identifies complement deactivation as an immunometabolic checkpoint reducing inflammaging Caloric restriction (CR) extends lifespan, yet the convergent immunometabolic mechanism of healthspan remains unclear. Using longitudinal plasma proteomics analyses in humans achieving 14% CR for 2 ye...

www.biorxiv.org/content/10.1...

Brain myelin as a deficient energy source in aging and disease Central nervous system (CNS) myelin may act as a dynamic energy store that supports brain metabolism; its consumption and replenishment is a newly recognized form of metabolic plasticity aimed at main...

Brain myelin as a deficient energy source in aging and disease www.cell.com/trends/endoc... Excellent discussion on how myelin fatty acid reserves may be reallocated during aging and neurodegeneration

#Throwback 🧪

COMMENT | A call for accessible tools to unlock single-cell immunometabolism research

J Van den Bossche et al.

Review @jem.org
Lipid metabolism and neuroinflammation: What is the link?
rupress.org/jem/article/...

We’re excited to announce the Young Investigators Special Issue in the Journal of Neuroimmunology! We will spotlight early-career researchers and support the next generation of discovery. Submit your original research and let your work be seen and recognized.
#CallForPaper

Mast cells regulate the brain-dura interface and CSF dynamics Dural mast cells control cerebrospinal fluid dynamics at critical brain-dura interfaces, specifically arachnoid cuff exit points. Their activation limits pathogen brain entry via histamine-induced vas...

Two very cool back-to-back papers in @cp-cell.bsky.social on roles of meningeal dural mast cells in stroke and CSF dynamics 🤩😍👇🏻

cell.com/cell/fulltext/S0092-8674(25)00748-2

cell.com/cell/fulltext/S0092-8674(25)00747-0

Led by the untaggable Wesley Godfrey, rockstar MD/PhD student