Andrew Seaton

Fleming’s legacy 2028 will mark the centenary of the observation of the inhibitory effects of the mould Penicillium notatum (now chrysogenum) on the growth of Staphylococcu

As the centenary of Fleming's discovery of penicillin approaches, drug-resistant infections increasingly impact those with least resource
Sustained action to safeguard antibiotics globally is needed including renewed commitment & leadership from the UK
doi.org/10.1093/jaca...
@raseaton66.bsky.social

It’s Day 1 of the BSAC Spring Conference 2025! Our President, Professor Andrew Seaton, opens the event with a warm welcome to what promises to be an inspiring two days of discussion, discovery, and action in the fight against #antimicrobialresistance🔗 bsac-conference.com #BSACSpring2025

Stability of tigecycline in elastomeric devices for OPAT - Tigecycline meets the 🇬🇧 YCD criteria of ≤5% degradation limit. Fantastic collaboration with 🌍 colleagues @bsacandjac.bsky.social @raseaton66.bsky.social academic.oup.com/jacamr/artic...

ICYMI: this adapted UK AWaRe list reached through consensus will support national #AntimicrobialStewardship and usage targets of the UK 2024–29 NAP
https://doi.org/10.1093/jacamr/dlae218
@dianeashiru.bsky.social @raseaton66.bsky.social @aliciad3.medsky.social
#JACAMRNews

Antifungal resistance is increasing globally, with more patients at risk of invasive fungal disease
There is an urgent need to standardise antifungal stewardship (AFS) in the UK—this position paper sets out the UK’s current AFS landscape:
https://doi.org/10.1093/jacamr/dlae209
#JACAMRNews #IDSky

The all-party parliamentary group on AMR

The All Parliamentary Group on AMR provides a platform to engage with policymakers about AMR. Supported by the British Society for Antimicrobial Chemotherapy, its members are determined to make AMR a political priority for the UK government.

Find out more about their role: tinyurl.com/3zzdrrvt

NHSGGC named Centre of Excellence for Antimicrobial Stewardship NHS Greater Glasgow and Clyde has become the first Scottish health board to be formally recognised for its work on antimicrobial stewardship and tackling the threat of antibiotic resistance. GAMSAS (G...

Fantastic news! NHS Greater Glasgow and Clyde has become the first Scottish health board to be formally recognised for its work on antimicrobial stewardship under the BSAC-led Global Antimicrobial Stewardship Accreditation Scheme 🎉 www.nhsggc.scot/nhsggc-named...

Antimicrobial resistance–attributable mortality: a patient-level analysis AbstractBackground. The impact of antimicrobial resistance (AMR) on death at the patient level is challenging to estimate. We aimed to characterize AMR-att

🦠 New research in @jac-amr.bsky.social reveals 4.2% of deaths in a UK teaching hospital were AMR-attributable, yet #AMR wasn't recorded as a cause in any case.

Intrinsic resistance (Enterococcus faecium, Pseudomonas aeruginosa) played a major role.

Read the study: academic.oup.com/jacamr/artic...

Great to see MP Danny Chambers, who is standing to become an Officer of the All-Party Parliamentary Group on AMR, highlighting the growing issue of antibiotic resistance in Ukraine during Prime Minister's Questions today. A critical and often overlooked consequence of armed conflict.

A qualitative study on the impact of the #COVID19 pandemic on the Scottish #AntimicrobialStewardship workforce revealed negative impacts on team roles, with unanticipated positive outcomes like raised awareness of the value of AMS teams
https://doi.org/10.1093/jacamr/dlae199
@raseaton66.bsky.social

Antimicrobial resistance–attributable mortality: a patient-level analysis AbstractBackground. The impact of antimicrobial resistance (AMR) on death at the patient level is challenging to estimate. We aimed to characterize AMR-att

#AMR is a risk to antibiotic failure & death, but if this happens, do we record it on death certificates? Our centre data = NO!

👉In 1 year, 4% of deaths were AMR-attributed & NONE were recorded on death certificates!👈

Need to quantify this better to increase awareness! #IDSky @jac-amr.bsky.social

Time to Staphylococcus aureus blood culture positivity is a useful marker for infective endocarditis

This retrospective cohort study of >1700 cases of SAB suggests that if TTP > 13 hrs, the patient is unlikely to have endocarditis (NPV 96%, 95%CI 95-97)

academic.oup.com/cid/advance-... #IDSky

“I am thrilled that we have received Level 2 Global Accreditation for the work my colleagues and I have done across Manx Care to help combat the significant risks posed by antimicrobial resistance."

London skyline including Westminster and Big Ben from the Queen Elizabeth 2 conference centre - site of the BSAC conference

Congratulations to @bsacandjac.bsky.social for an outstanding 2 day Policy to Practice winter conference in the heart of London. Ready to meet the #AMR and #AMS challenges ahead in 2025 #infection2024

Zubir Ahmed MP reinforcing the importance and determination of the UK Government to tackle AMR and preserve antibiotics. Complimenting @bsacandjac.bsky.social for their world leading advocacy for change in #AMR across the world 👏. #infection2024

Call for Global Standards in Antimicrobial Stability Testing to Improve Outpatient Care - The British Society for Antimicrobial Chemotherapy

‘By standardising stability testing guidelines, we can broaden treatment options for patients with serious infections, improve clinical outcomes, advance antimicrobial stewardship, and reduce healthcare costs.’ @jac-amr.bsky.social @raseaton66.bsky.social @mgilchrist123.bsky.social

In Scotland we use empirical Gentamicin primarily for extended Gram negative cover rather than vs Pseudomonas

Check it out! BSAC's OPAT Conference 2024 has been featured on the ID:IOTS Podcast @idiots-pod.bsky.social! You can find the episode on Spotify - episode notes here: idiots.notion.site/94-BSAC-OPAT... @raseaton66.bsky.social

Did you exclude those with acute moderately severe cellulitis and acute HF requiring parenteral abx/diuretics?

👏 What proportion required IP assessment and / or IV Rx for whatever indication? Did you exclude those requiring empirical IV Rx initially via other ambulatory services?

🔥SNAP passed 3500🔥
Writing papers:
Cefazolin (MSSA) and penicillin (PSSA) vs (flu)clox
Recruiting:
Adj clinda vs not (all)
Adj cefazolin vs not (MRSA)
Oral switch vs IV (all)
Cefazolin +/- Erta/Placebo (MSSA)
Dapto vs Vanco (MRSA)
Coming "soon":
Rifampin vs. none for PVIE (all)
Ref: Dr.Lee #idsky

Graphs show single dose IM oily chloramphenicol as effective as 5 days of penicillin in epidemic meningococcal meningitis in sub Saharan Africa

Prof Sir Brian Greenwood’s @lshtm.bsky.social retirement lecture on zoom. From science to clinical practice, public health and policy. Meningitis to Malaria. Amongst many many contributions- single dose oily chloramphenicol for meningococcal infection #AMSsky

Why community-led research is vital in the fight against AMR | News | Wellcome Antimicrobial resistance is one of the world’s biggest health threats. Learn more about its realities in Khayelitsha, South Africa.

More people die from antimicrobial resistance in South Africa than from self-harm, interpersonal violence or transport injuries. wellcome.org/news/you-can...

A quick reminder that the BSAC Winter Conference begins next week, 4-5 December! If you haven't booked your place yet, there's still time bsac.org.uk/infection2024/

ABX durations for secondary peritonitis and acute cholecystitis and cholangitis

🌟 ABX Pearl of the Day: Duration of treatment in intra-abdominal infections (IAI)! 💊

💡 Q: How long should I treat IAI after source control?
🔍 A: While STOP-IT trial calls for 4 days post-source control, there are notable exceptions. See infographic for details 👇
#IDsky #AMSsky #MedSky #Pharmsky

Shorter is better and oral is better. But when no oral and deep seated / difficult to eradicate focus you need #OPAT 🙌 or maybe you just stay in hospital?

Who and how Antimicrobials are prescribed has changed. Our #AMS initiatives need to acknowledge and embrace this www.nss.nhs.scot/media/5668/a... #WAAW2024 #WAAW

93. World AMR Awareness Week special: The Scottish Antimicrobial Prescribing Group (SAPG) - ID:IOTS - Infectious Disease Insight Of Two Specialists WAAW! This week, to celebrate World AMR Awareness Week, Callum is Joined by Andrew, Fran, Jo and Simon from the Scottish Antimicrobial Prescribing Group. Listen in to hear all about SAPG and their imp...

WAAW! What an amazing podcast episode!

World AMR Awareness Week special: The Scottish Antimicrobial Prescribing Group (SAPG).

Who are they? What do they do? Tune in to find out:
www.buzzsprout.com/1782416/epis...

#antibioticguardian #KeepAntibioticsWorking #WAAW #IDsky