bioRxiv Genetics

NTBC dosing and outcomes in hereditary tyrosinemia type 1: insights from a representative human model and 99 patients https://www.biorxiv.org/content/10.1101/2025.10.06.680797v1

Global Mapping of Combinatorial Chromatin Regulatory Events Using Hi-Plex CUT&Tag https://www.biorxiv.org/content/10.1101/2025.10.06.680180v1

Urbanization drives genetic erosion and population structure in a historically connected carnivore population https://www.biorxiv.org/content/10.1101/2025.10.03.680202v1

Comparing the genetic diversity of two threatened Rhyticeros hornbill species with contrasting geographic range sizes https://www.biorxiv.org/content/10.1101/2025.10.06.680625v1

Transfer Learning for Survival-based Clustering of Predictors with an Application to TP53 Mutation Annotation https://www.biorxiv.org/content/10.1101/2025.10.06.680732v1

Uncovering the genetic basis of agronomic traits in over 1,000 grapevine genotypes derived from a disease resistance breeding program https://www.biorxiv.org/content/10.1101/2025.10.05.680539v1

In Vitro Modulation of MECP2 Expression via Antisense Inhibition of miR-132-3p in SH-SY5Y Cells https://www.biorxiv.org/content/10.1101/2025.10.06.680678v1

Tracing the illicit Peruvian delicacy: proof-of-concept multiplex-PCR for the simultaneous detection of seven commercial Macrobrachium prawn species https://www.biorxiv.org/content/10.1101/2025.10.03.680321v1

Retinoic acid production via the ray-finned fish gene beta-carotene oxygenase 1-like is essential for juvenile development https://www.biorxiv.org/content/10.1101/2025.09.30.679646v1

Optimizing CRISPR/Cas9 mutagenesis in Drosophila da neurons to avoid cytotoxicity https://www.biorxiv.org/content/10.1101/2025.10.03.680356v1

EWF 2.0: Exact sampling from the Wright-Fisher diffusion with time-varying demography https://www.biorxiv.org/content/10.1101/2025.10.02.679989v1

Hepatic ceramide synthesis links systemic inflammation to organelle dysfunction in cancer https://www.biorxiv.org/content/10.1101/2025.10.01.679814v1

SWING domains prime chromatin for nuclear body mediated gene regulation https://www.biorxiv.org/content/10.1101/2025.10.01.679801v1

Random forest model improves annotation and discovery of variants of uncertain significance in Alzheimer's and other neurological disorders https://www.biorxiv.org/content/10.1101/2025.10.02.680068v1

Genetic background influences the effects of RNAi-by-feeding for DNA methyltransferases in Daphnia pulex. https://www.biorxiv.org/content/10.1101/2025.10.02.680119v1

Resilin, the gene for the molecular spring: its roles in the flight and jumpingof Drosophila https://www.biorxiv.org/content/10.1101/2025.10.01.678482v1

Loss of adenylosuccinate synthetase 1 in mice recapitulates features of ADSS1 myopathy https://www.biorxiv.org/content/10.1101/2025.10.01.679796v1

Nephrobase Cell+: Multimodal Single-Cell Foundation Model for Decoding Kidney Biology https://www.biorxiv.org/content/10.1101/2025.09.30.679471v1

Genome-wide Discovery of lncRNAs in Mucorales Reveals Essential Roles in Development and Fungal Biology https://www.biorxiv.org/content/10.1101/2025.10.01.679568v1

The Cumulative Distribution Function Based Method for Random Drift Model https://www.biorxiv.org/content/10.1101/2025.09.29.679385v1

SAFE-LD: A novel method for the estimation of linkage disequilibrium from summary statistics https://www.biorxiv.org/content/10.1101/2025.09.29.679154v1

A comprehensive functional landscape of α-tubulin TUBA1A variants illuminates microtubule biology and refines clinical classification https://www.biorxiv.org/content/10.1101/2025.09.29.679168v1

Vitamin B12 alleviates Verheij syndrome-like defects via phospholipid remodeling in a C. elegans PUF60 spliceosomopathy model https://www.biorxiv.org/content/10.1101/2025.09.29.678827v1

Engineered Promoter System Enables High-efficiency Transgenic CRISPR Editing in Malaria Transmitting Mosquito Anopheles sinensis https://www.biorxiv.org/content/10.1101/2025.09.29.679135v1

Monocyte Subset Predict Clinical Outcomes in Fibrotic Hypersensitivity Pneumonitis https://www.biorxiv.org/content/10.1101/2025.09.25.678673v1

Modelling the dynamics of transposable elements in genomes under asexual reproduction using agent-based model https://www.biorxiv.org/content/10.1101/2025.09.28.679026v1

Expanding the gain-variance Pareto via optimal recycling and genomic mating https://www.biorxiv.org/content/10.1101/2025.09.28.679020v1

Is it chaotic? Chicken Linkage Disequilibrium and quantitative trait loci https://www.biorxiv.org/content/10.1101/2025.09.28.679118v1

Unraveling the Molecular and Physiological Roles of Signal Peptide Peptidase A (SppA) in Flavobacterium columnare https://www.biorxiv.org/content/10.1101/2025.09.26.678728v1

Single-cell dissection of urine-derived stem cell hierarchies reveals robust chondrogenesis and clinical scalability https://www.biorxiv.org/content/10.1101/2025.09.26.678723v1