Leon-Samuel Icking

**GROUP LEADER VACANCY**

Discovery Plant Sciences

Got burning questions about how plants grow and respond to their environment? So do we. Come join us!

#johninnescentre
#plantscijobs

Now that OpenCRISPR is in nature and rekindled the 'what's-a-novel-sequence' debate, I'm happy to share an app to check this, which I built for fun some time ago.

fuerstlab.shinyapps.io/SeqNovelty/

quick 🧵

📌

DNA-Programmable Protein Degradation: Dynamic Control of Proteolysis-Targeting Chimera Activity via DNA Hybridization and Strand Displacement Targeted protein degradation is a powerful therapeutic approach: expanding the druggable proteome, providing enhanced selectivity, and having the ability to overcome conventional resistance mechanisms...

We have developed a dynamic ‘off’ switch for PROTAC activity by using DNA linkers and toehold mediated strand displacement!

Published in JACS Au @pubs.acs.org

Led by Disha Kashyap, with @shozebhaider.bsky.social + Tom Milne

@uclchemistry.bsky.social #chemsky 🧪🧬
pubs.acs.org/doi/10.1021/...

Iconic

Thank you everyone for the congratulations and the large number of applications! I want to specifically encourage applications for these positions:
* Postdoc in structural biology (cryoEM, ideally with X-ray too)
* Full time lab manager/technician with wetlab experience

Vaccines are safe. Fuck all y'all fascist motherfuckers

GitHub - cxli233/FriendsDontLetFriends: Friends don't let friends make certain types of data visualization - What are they and why are they bad. Friends don't let friends make certain types of data visualization - What are they and why are they bad. - GitHub - cxli233/FriendsDontLetFriends: Friends don't let friends make certain ty...

There has been an influx of new follows. I want to share that in addition to posting plant science, biochemistry, and genomics, also post data visualization.

My most popular GitHub repo is "Friends don't let friends make bad graphs". github.com/cxli233/Frie...
An assay on data vis w/ examples.

GG England! Worthy of a final, Spain played their heart out

New preprint: In situ Architecture of #Plasmodesmata.

Using #cryoET, #AlphaFold & proteomics, we uncover the native organization of plant intercellular nanopores.

🔗 doi.org/10.1101/2025...

🧪🧵1/n
#teamtomo #PlantScience #Physcomitrium #Arabidopsis #cryoEM

Due to some server issues, some applications have been lost, particularly the ones submitted within 12h of the announcement, if that’s your case, it’s better to resubmit, sorry everyone 🙏🏻

Can a drop of rain prime plants for survival? 🌧️🌿

Join us as @rimchaudhury15.bsky.social (from @hartman-plantlab.com) reveals how Arabidopsis uses rain as a mechano-signal to boost flooding tolerance via calcium, jasmonate and ethylene pathways.

📅 Fri, Jul 25 | 🕥 10:15 |📍KS 00.009
#PlantScience

I am super excited to announce that I will be starting my lab at the Department of Pharmacology of the University of Zurich in Switzerland next year!

A copper-dependent, redox-based hydrogen peroxide perception in plants https://www.biorxiv.org/content/10.1101/2025.07.22.666036v1

Cell Free Protein Synthesis (E. coli) Ginkgo’s cell free protein synthesis (CFPS) kit is an E. coli transcription/translation system optimized to produce proteins from a T7 RNA Polymerase promoter.  Reactions consist of a bacterial cell l...

Cell Free Protein Synthesis (E. coli) – Ginkgo Reagents share.google/Rh7kCQMWuhN4...

Cell Free Protein Synthesis (E. coli) Ginkgo’s cell free protein synthesis (CFPS) kit is an E. coli transcription/translation system optimized to produce proteins from a T7 RNA Polymerase promoter.  Reactions consist of a bacterial cell l...

Ginkgo has launched an E.coli-based Cell Free Protein Synthesis reagent!

reagents.ginkgo.bio/products/cel...

A developmental switch controls cell-to-cell transport in roots via pectin-linked plasmodesmata changes #research #MolecularPlant cell.com/molecular-pl...

Paper 🚨!!
Plasmodesmata transport first in both, then only in one direction in roots! Congratulations to Lea and @mariebarberon.bsky.social !!

Holy shit the Dems and Reps are so fucking scared I love it

Screenshot of protein sequences in MS Word

What's the best software for making and styling a protein sequence alignment? Please tell me there's something better than MS Word?

ClipKIT in the browser: fast online trimming of multiple sequence alignments for phylogenetics Abstract. Multiple sequence alignment trimming can help improve phylogenetic signal and reduce computational load. ClipKIT trims multiple sequence alignmen

NEW publication: Super happy to see the ClipKIT web application now published in Nucleic Acids Research @narjournal.bsky.social!!

Trim your alignments for FREE on us :D

Application: clipkit.genomelybio.com#/

Manuscript: academic.oup.com/nar/article/...

#phylogenetics #evolution #bioinformatics

This has some meme potential

I'll be at this meeting in Edinburgh in September. Happy to chat to anyone going about publishing in Science!
#PlantScience

Today's a full day of celebrations at the Faculty of Biology!

We start with a symposium to celebrate 50 years of Geobotany, followed by a full afternoon and evening of Fakultätsfest.

Everyone is welcome: faculty, guests, friends and family.

Andrew Wakefield's Attention Score. Don't be like Andrew Wakefield. https://pubmed.ncbi.nlm.nih.gov/9500320/

1. Wow awesome, high citations AND altmetrics. This must be the raddest paper of all time. When I grow up to be a researcher, I want to be JUST LIKE DISGRACED EX-DOCTOR ANDREW WAKEFIELD.

He published this attack on combined MMR vaccines while secretly patenting single dose vaccines btw.
4/9

Too bad! Best of luck to all other candidates

Buddy of mine is asking about the completion of the Masters degree in the last 6 months, is this a hard threshold? I think he finished early last year and checks all other criteria

β-sheet stabilization of the island domain underlies ligand-induced LRR-RP activation of plant immune signaling https://www.biorxiv.org/content/10.1101/2025.07.07.663532v1

INVESTING FINANCE BANKS INVESTING WALL STREET HEDGE FUNDS MSA Goldman Sachs asks in biotech research report: 'Is curing patients a sustainable business model?' Tae Kim | afirstadopter had 81S PHET Wed. 11 Aprf 2018 | Updard 7:20 PM ET wed, 11 Agrl 2019 # CNBC ess of its [G us

With all this talk of Sunak and Goldman Sachs’s, thought I would post this. It sums up everything that’s wrong with the world.