Johannes Hohlbein

Not me discovering time is linear after the abstract deadline!
#meme #lablaughs #ScienceHumor #AcademicSky

“ Sitting next to the Nazis' newly appointed minister of education at a banquet, he was asked, "And how is mathematics in Göttingen now that it has been freed of the Jewish influence?" "Mathematics in Göttingen?" Hilbert repiled. "There is really none any more." ”

Fingers crossed. :)

Or for a segmentation challenge: green tomatoes in front of green leaves and ivy.

Two tomatoes plants showing many green (and some black) tomatoes but no red ones.

Will there be enough sunlight to turn the tomatoes from green to red? #DutchSummer

Small shelf showing the refrigerated milk section of a small Dutch supermarket. At least 25!different types, sizes, and brands of milk and milk-like drinks are visible.

Refrigerated “milk” section in a very (!) small Dutch 🇳🇱 Albert Heijn: >25 different brands, sizes, and types. “Fresh” milk in most French 🇫🇷 and Belgian 🇧🇪 super markets I visited: 0. Why? Simply not a thing?

Congrats and all the best for your new endeavours!

💥 We have 3 positions open in my lab in Basel, Switzerland🇨🇭:
#nanopores #smFRET #biomolecular #dynamics #singleMolecules

We’re looking for talented & ambitious new colleagues enthusiastic about biomolecular dynamics & single-molecule tech.

Please share broadly, thank you!🤝

schmid.chemie.unibas.ch

🚨 2 × PhD positions @EPFL! 🚨
Help us push the boundaries of fluorescence microscopy - DNA nanotech, custom optics & spatial omics in Lausanne 🇨🇭. Start Jan 2026. Send CV + motivation + 2 refs → fschueder@ethz.ch
#PhD #Hiring #microscopy #SuperResolution #SpatialOmics #DNAPAINT #FLASHPAINT

1/3 🚨🥳New paper out in Advanced Materials!
We bring attomolar, amplification-free DNA detection to the point-of-care using DNA origami nanoantennas.🧬Check it out here: advanced.onlinelibrary.wiley.com/doi/10.1002/...

Opening for a professorship in multimodal imaging in the context of our cluster of excellence #3DMM2O. Here is the full advertisement with all details: tinyurl.com/2ksy2b2s

ABEL-FRET bridges the timescale gap in single-molecule measurements of the structural dynamics in the A2A adenosine receptor The functional complexity of G protein-coupled receptors (GPCRs) arises from their structural dynamics, which span timescales from nanoseconds to minutes. Single-molecule Förster Resonance Energy Tran...

#smFRET-lovers! Imagine, you got nice burst data with freely diffusing molecules 🙌🔬

BUT
1) Immobilization does not work🧲🤬
2) Transitions are longer than diffusion time, but shorter than frametime of your TIRF⏱️

Solution: try ABEL-trap!💕

📜bioRxiv:
doi.org/10.1101/2025.07.22.666123

Ever wondered what happens when therapeutic antibodies bind to cancer cells? In our latest study, we used multiplexed 3D-RESI to directly visualize how anti-CD20 antibodies interact with their receptors, revealing their precise arrangement at single-protein resolution. (1/6)

Biologist folk (especially in evolutionary biology and/or ecology, but it don’t matter):

Can you give me your favorite examples of trade offs in biology? Organism or system don’t matter. Primary literature or reviews preferred.

Notre-Dame de Reims. Front view.

Notre-Dame de Reims. Inside view.

Notre-Dame de Paris. Front view.

Notre-Dame de Paris. Inside view.

Shout out to the lunatics who thought they can pull off cathedrals some 800 years ago.

Das “inhaltlich stellen” der AfD durch die CDU scheint ja bestens zu funktionieren. Für die AfD.

Some phenotypic and genotypic variation?

(1/n) A simple, ultrastable, and cost-effective oxygen-scavenging system for long-term DNA-PAINT imaging

Please check out our new study on the benefits of sodium sulfite as oxygen scavenging system for DNA-PAINT.
👇🧵

#SuperResolution #DNAPAINT #SMLM #Microscopy

Well deserved, Lore!

Sure, but even that is largely to the discretion of the editor and any revision is likely to add ...much... more text. In any case, good luck with the manuscript!

No, IMHO a direct submission is often more "time efficient" unless you know specific editors. Learning the very hard way, I also stopped formatting (first) submissions to match specific journal styles...

"hey, why don't you just send us your manuscript?"

All good. Brought back some good memories. So thank you for that.

Lamb & Flag next to St John’s?

FYI. Firefox issued a warning

Have you been to LinkedIn though? Seems increasingly busy. Just a bit "spassbefreit" over there IMHO :)

I like being here, but if you look at BlueSky (bsky-users.theo.io) things are looking rather stagnant.

Humble request by a reviewer: DO: Use line numbering. DON'T: restart the numbers on each page whilst omitting page numbers. DO: align the line numbers with the actual text. Thank you.

Two avocado plants in a pot. Height around 30cm each.

Achieving personal growth. My five tips below. Number 4 will shock you.

True. Show more click bait.