STEMCELL Science News

🥼 Dr. Olivier Lantz and colleagues performed scRNAseq and spatial analysis of both T cells and tumoral cells. #thymoma

T cells at all stages of T cell development, from immature to mature, were present in the tumor.

🆕 Discover more: https://bit.ly/47jMWyy

A gourd-geous image of our lamin B1 cell line for your Halloween cell-ebrations! 🎃🧬

📸 Thanks to @oozguc.bsky.social for sharing this unbe-leaf-able shot!

#FluorescenceFriday

#FluorescenceFriday

Discover the role and mechanism of family with sequence similarity 3 member B (FAM3B) in hepatic fibrosis.

Scientists found that FAM3B activates hepatic stellate cells to accelerate hepatic fibrosis by promoting glucose metabolism.

https://bit.ly/3L96WLH

Explore Zanubrutinib's potential effects on aging lung fibrosis!

Scientists show that Zanubrutinib may alleviate the senescence-associated phenotype and mitigate senescence-associated #PulmonaryFibrosis by inhibiting the Wnt/β-catenin signaling pathway.

https://bit.ly/4hz0Yj4

(Cell)ebrating Halloween! 🎃 #HappyHalloween

🔬 Scientists established urinary proteomics as a predictive tool for ICI responsiveness and to elucidate its relationship with tumor dynamics and tumor microenvironment remodeling in biliary tract cancer.

🔗 https://bit.ly/433kePO

🥼 A team of @unimelb.bsky.social scientists led by Dr. Axel Kallies identify the chromatin organizer and transcriptional regulator SATB1 as a central regulator of precursor fate and effector differentiation of CD8+ T cells both in infection and in cancer.

🔗 https://go.nature.com/3X4cae4

📢 New @cp-cellstemcell.bsky.social study!

Investigators showed that methyltransferase-like 3 deficiency reverts naive hESCs to a #totipotent-like state with reactivation and chromatin resetting of 8C-associated genes, eRNAs, and long terminal repeats.

https://bit.ly/4ns8ZaY

Lieber Institute For Brain Development - Staff Scientist I, Translational Neuroscience A little about us:The Lieber Institute for Brain Development (LIBD) was established in 2010 to plot a new course in biomedical research that would change the lives of individuals affected with develop...

We are hiring for a PhD-level Staff Scientist to join our teams in the Translational Neuroscience Division @lieberinstitute.bsky.social. This is an exciting opportunity to work at the intersection of human 🧠 neuroanatomy and molecular neuroscience

recruiting.paylocity.com/recruiting/j...

🎉🔬 Congratulations to Dr. Asbjørn Christophersen, who received the Young Investigator 2025 award from the Scandinavian Society for #Immunology for his research on disease-specific T cells.

👉 Read about Dr. Christophersen's work: https://bit.ly/4hANHGQ

🐁 Scientists at @uni-saarland.de determined how Tafazzin deficiency affects mouse pancreatic islet metabolism and hormone secretion, and whether systemic signals, such as circulating factors, modulate these effects in vivo.

@diabetologiajnl.bsky.social | https://bit.ly/48SYeek

🧬 Scientists with Dr. Satyabrata Das uncovered the transcriptional and epigenetic changes orchestrated by ETV2 to promote the hematoendothelial lineage while suppressing other mesodermal lineages.

🔗 https://bit.ly/47JittM

Researchers with Dr. Nobuaki Fukuma at @columbiauniversity.bsky.social investigated whether and how cardiomyocyte NO-sensitive soluble guanylyl cyclase mediates female-specific, adaptive right ventricular pressure-overload remodeling.

https://bit.ly/3WYQdx2

🔎 Central South University scientists uncover a novel mechanism by which palmitoylation regulates #ferroptosis in #ProstateCancer through modulating ACSL4 stability.

They highlight the ZDHHC2-USP19-ACSL4 axis as a druggable target. 🎯

🔗 https://bit.ly/4qwA4wA

Gorgeous! Happy #FluorescenceFriday! 🤩

New in @commsbio.nature.com!💡

A team of scientists from Inner Mongolia University found that low activity or depletion of MTHFD2 enhances the degree of tumor cell #Senescence in #BreastCancer cells and decreases their resistance to chemotherapeutic agents. 💊

https://go.nature.com/3JoiFVY

🧫 This study underscores the importance of human #organoid-based phenotypic monitoring and inter/intrahost genotypic monitoring for assessing the zoonotic risk of avian #influenza viruses.

👉 https://bit.ly/3Jhx0U0

Postdoc Researcher: Modelling Alzheimer’s’ with iPSCs & AI Phenotyping Two Postdoctoral Researchers at University of Oxford to study Alzheimer’s disease using AI and iPSC models in the Translational Neuroscience Group.

Two Postdoctoral Researcher Positions at University of Oxford to study Alzheimer’s disease using AI and iPSC models in the Translational Neuroscience Group. Closing date: 6th November

www.dementiaresearcher.nihr.ac.uk/job/postdoc-...

Scientists led by Drs. Christopher Glass & Nicole Coufal reveal mechanisms by which reduced microglial MEF2C could contribute to the development of neurological diseases.

📍Now in @natimmunol.nature.com: go.nature.com/3WDPamh

Drs. @fabiantheis.bsky.social, @erwinschoof.bsky.social, @porsebo.bsky.social, & team developed a mass spectrometry–based method for performing single-cell proteomics. They showed their method on bone marrow samples from healthy human donors.

🔗 bit.ly/470CH1S

Integrated epigenetic and genetic programming of primary human T cells Nature Biotechnology - Multiplexed editing in primary human T cells generates enhanced immune cell therapies.

Happy to share our latest paper in Nature Biotech, led by graduate student Laine Goudy, joint with Luke Gilbert at Arc, developing CRISPRon/off technology for epigenetic programming of human T cells.

Don't miss out on the chance to win one of these new immune cell pins! 🤩

An iPSC-cardiac myocyte (heart muscle cell) in cell culture photographed through a microscope by former Burnette lab graduate student, Dr. James Hayes. We are preparing cover submissions for his last two first author papers from the lab! Actin filaments are shown. #CellBiology

Congratulations Dr. Wilfredo Garcia-Beltran from the @ragoninstitute.bsky.social on receiving a NIH High-Risk, High-Reward Research Program award!

This grant will support a new project that retools #NaturalKiller cells to better locate, enter, and destroy solid tumors: https://bit.ly/4nZMWcG

🔬 Scientists compared the proteomes of adherent and CSC-enriched tumor sphere cultures in a tumor progression model of myxoid #liposarcoma composed of three cell lines showing increasing aggressiveness after being serially transplanted in mice.

👉 https://bit.ly/4o1xa0W

🛡️ Scientists demonstrated that the adipogenically differentiated MSCs enhance the survival and chemoresistance of acute myeloid leukemia cells by modulating metabolic and signaling pathways.

👉 https://bit.ly/3We8bvg

Researchers at Hubrecht Institute and Radboud University developed an animal-free gel in which organoids can grow and expand long-term. The PIC-invasin gel allows for more consistent, ethical and affordable organoid research. @hansclevers.bsky.social @pnas.org 
🔗 https://f.mtr.cool/cekttmhhtn

Dr. Abhijit Basu led this study showing for the first time that UVA induces global DNA methylation as a compensatory mechanism in response to UVA-induced DNA damage in #melanoma and melanocyte cells.

🔓 Read the full story here: go.nature.com/4nkRERl

Dr. Dan Huh and colleagues present a microengineered system that enables vascularization of human tumor explants and their controlled perfusion with immune cells to model the activity of CAR-T cells in the tumor microenvironment. 🧫

https://go.nature.com/3WgA0D5