Andreas H. Laustsen-Kiel

Also a big thanks to our generous funders, Villum Fonden, European Research Council (ERC), Wellcome Trust, and Consejo Nacional de Ciencia y Tecnología!

Johannes R. Loeffler, Andrew B. Ward, Kim Boddum, Jens Preben Morth, and Esperanza Rivera de Torre from @dtu.dk, Universidad Nacional Autónoma de México, Sophion Bioscience, and Scripps Research.

Thanks to great co-authors, including Anna Damsbo Jensen, Nick J. Burlet, Monica L. Fernández-Quintero, Melisa Benard-Valle, Max Overath, Alid Guadarrama-Martínez, Anneline Vlamynck, Ida Bisbo, César Noé Villalobos Carrizosa, Tulika Laprade, Alejandro Alagon...

While the work has immediate implications for snakebite envenoming, the methodologies developed here are generally useful for developing broadly-neutralising antibodies.

Structural mechanisms behind the neutralisation of long-chain α-neurotoxins by broadly neutralising VHHs discovered using a consensus antigen - Communications Chemistry Snakebite envenoming remains a critical global health issue due to the diverse antigenic profiles of snake venoms. Here, the authors develop a long-chain consensus α-neurotoxin to identify broadly neu...

Read article here: www.nature.com/articles/s42...

Excited to share the newest research paper from our lab, where we discover #nanobodies against #snake #neurotoxins using specially designed #consensus toxins and phage display technology. Link to paper in first comment.

Thanks also to our generous funders, Villum Fonden, European Research Council, Wellcome Trust, and Consejo Nacional de Ciencia y Tecnología!

Thanks to my fantastic co-authors, Anna Damsbo Jensen,
Melisa Benard-Valle, Tom Jansen, Nick J. Burlet, Max Overath, Alid Guadarrama-Martínez, Kim Boddum, Alejandro Alagon, and Esperanza Rivera de Torre from
DTU, UNAM, and Sophion Biosciences.
.

New research article where we use consensus #toxins as #antigens for discovery of #nanobodies, showcasing this with short-chain alpha-neurotoxins from snakes - notoriously difficult to discover antibodies against.

Read article here:https://www.tandfonline.com/doi/full/10.1080/19420862.2025.2522838

Thanks to Laura Tran for highlighting our work on Binding Proteins against cholera toxin: www.the-scientist.com/new-cholera-...

Original research article: www.nature.com/articles/s41...

Happy to share this "Ubegribeligt" podcast episode (in Danish) on venom and antivenom, which I had the pleasure of doing together with Huxi Bach from Danmarks Radio: www.dr.dk/lyd/p1/ubegr...
In the podcast, we discuss animal venoms, antivenom, and R&D, and spinout!

... Sandra Wingaard Thrane & Nuria Canibe.

Thanks to GUDP - Grønt Udviklings- & Demonstrationsprogram for the financial support to make this happen!

The work was done by researchers from
Bactolife, Aarhus University, Technical University of Denmark, and Università degli Studi di Parma, including Jiajia Xu, Melania Andrani, Rikke Brødsgaard Kjærup, Tina Sørensen Dalgaard, Carsten Eriksen, Susanne Brix Pedersen...

The Binding Proteins developed here retain full functionality when subjected to the very harsh process of pelleting, as part of admixing them into piglet feed, as can be seen in the figure.

Pleased to share this new publication on the effects of Binding Proteins against virulence factors from enterotoxigenic E. coli: jasbsci.biomedcentral.com/articles/10....

As an #antibody engineer, I find it super interesting that we in this study show how stable #Binding #Proteins can be!

🚨 We’re hiring a PhD student! 🚨

Join us at DTU Bioengineering + collaborators Messoud & Håkan Ashina + Esperanza Rivera de Torre to bring preventative migraine therapeutics from 💻 to 🧠

🔗 Apply: lnkd.in/dCRU_EN3

🔍 Project: lnkd.in/dbpi8MwX

I co-wrote an opinion piece in a Danish newspaper. There are a few EU initiatives focused on recruiting american scientist. These ignore that the developments in the US the past years have spread here as well. We need a strategy and stronger political will, if we are to be a safe haven for science.

🚨 Big news! We’ve received a NovoNordisk Foundation Tandem Grant for #MIGRAINE — designing #AI-powered #GPCR-targeting biologics for chronic migraine. From computer to human in 4 years. Proud to team up with Messoud and Hakan Ashina, as well as Esperanza Rivera de Torre!
🧠 + 💊 + 🧬 = new hope.

Entrepreneurship | Center for Antibody Technologies In the Center for Antibody Technologies, we strive to use scientific research to solve problems […]

Read more about the companies: tropicalpharmacology.com/entrepreneur...
These include: Bactolife, VenomAid Diagnostics, Chromologics, Biosyntia, Antag Therapeutics, VenomAb, Combotope Therapeutics ApS, Agrobiomics, and soon-to-be-a-company Y-kings (bii.dk/bio-studio-p...)

Entrepreneurship | Center for Antibody Technologies In the Center for Antibody Technologies, we strive to use scientific research to solve problems […]

DTU has a large number of excellent and innovative researchers, and each year more than 100 companies are spun out of the university, so receiving this award is very humbling.

I am grateful to the Technical University of Denmark (DTU) who kindly awarded me with the university's Innovation Award 2025 for my contributions to innovation, entrepreneurship, and spinout of companies.
www.dtu.dk/nyheder/alle...

Snake enthusiast survived hundreds of bites. Now his blood is aiding the search for a universal antivenom Blood from a snake enthusiast who's been bitten hundreds of times aided the search for a universal snakebite treatment

I shared thoughts with @statnews.com on new research aiming to develop a universal antivenom, using antibodies from Tim Friede’s decades of self-immunization. Thanks to @usha.bsky.social for including me in the scientific discussion. 🐍👇 www.statnews.com/2025/05/02/d...

He injected himself with venom for decades. Can his antibodies help snakebite victims? A cocktail of antibodies from snake enthusiast Tim Friede protected mice from many deadly venoms—but some say the study has ethical issues

I had the chance to comment on a new study in Cell about the development of human monoclonal antibodies for #snakebite treatments. Grateful to @nerdychristie.bsky.social & @science.org for including me in the scientific discussion! Fascinating work. 🐍👇 www.science.org/content/arti...

Practical progress towards the development of recombinant antivenoms for snakebite envenoming Snakebite envenoming is a neglected tropical disease that affects millions globally each year. In recent years, research into the potential production of recombinant antivenoms, formulated using mi...

Our review article on progress towards #recombinant #antivenoms for #snakebite is now published at www.tandfonline.com/doi/full/10....
We cover snakebite, methods for #mAb discovery, do a deep dive on mAbs for neurotoxins, and discuss what is needed next to get this from concept to clinic.

Huge thanks to all co-authors: Gina Ross, Everardo Remi Rodriguez Rodriguez, Sandra Wingaard Thrane, Anne Ljungars, and Winnie E. Svendsen from VenomAid Diagnostics, DTU Bioengineering, and @Bactolife — and to Innovation Fund Denmark for supporting this work!

This work demonstrates an easy-to-use, versatile, and low-cost diagnostic platform that can be adapted for the sensitive and robust detection of toxins and contaminants.

assays like lateral flow assays.

We applied this method to detect the glycosyltransferase domain of Clostridioides difficile toxin B, achieving detection limits of:
0.025 µg/mL in spiked running buffer
1 µg/mL in spiked human fecal samples.

In this article, we explore how cellulose-binding domains (CBDs) can be harnessed to control the immobilization of immunoreagents—such as single-domain antibodies—onto paper substrates like nitrocellulose or cellulose, improving the sensitivity and specificity of paper-based...

New scientific article from the VenomAid Diagnostics in collaboration with the Center for Antibody Technologies at Danmarks Tekniske Universitet - DTU and Bactolife, led by our fantastic PhD student Selma Blom Belfakir!

Read the article here: www.sciencedirect.com/science/arti...

Thanks to Henrik Reinberg Simonsen from Sundhedspolitisk Tidsskrift for the fun interview on what cultural experiences I enjoy and for putting a bit of focus on YATSI's competition Denmark's Best Science Meme: sundhedskultur.dk/kultur/905-v...