Albert Gandioso Ubieto

π-Extended Ru–COUBPY Photosensitizers for In Vivo Anticancer Phototherapy Using One-Photon 780 nm Near-Infrared Light Photodynamic therapy (PDT) is a promising cancer treatment modality, offering precise spatial and temporal control of drug activation using light. However, clinical translation of current photosensiti...

The study on the nanomolar phototoxic Ru(II) COUBPY anticancer agents in vivo activated with NIR light is now published in @jacs.acspublications.org Wonderful collaboration with @martaealberto.bsky.social
@icmoluv.bsky.social @gassergroup.bsky.social @agandioso.bsky.social
doi.org/10.1021/jacs...

Inverse Correlation between Endoplasmic Reticulum Stress Intensity and Antitumor Immune Response with Ruthenium(II)-Based Photosensitizers for the Photodynamic Therapy of Head and Neck Squamous Cell Carcinoma Photodynamic therapy (PDT) is a promising strategy for head and neck squamous cell carcinoma (HNSCC), but the immune consequences of tumor cell death remain incompletely understood. We compared two ruthenium(II) polypyridine photosensitizers (PSs) in HNSCC models and found that both were potently phototoxic (nanomolar IC50s), triggered diverse cell death pathways (including autophagy and ferroptosis), and promoted hallmark danger signals of immunogenic cell death (ICD). Strikingly, only one PS induced apoptosis and strong endoplasmic reticulum (ER) stress, yet paradoxically led to immune tolerance in vivo. Conversely, the PS that did not induce apoptotic cell death with milder stress responses resulted in a better antitumor immunity in vivo. These unexpected findings challenge the prevailing view that PDT-triggered apoptosis and ER stress are essential for ICD. Our study underscores the complexity of PDT-induced cell death balance and immunogenic signals and highlights the need to redefine ICD-inducing criteria for the rational design of next-generation PSs.

Thrilled to announce that the last two collaborations from my postdoc in the @gassergroup.bsky.social are now published in J. Med. Chem. and JACS. ⚗️🧪
Congrats to all co-authors for the excellent work!
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/abs/10.1...

Selection of Ruthenium Polypyridyl Complex-Modified Aptamers for Photodynamic Therapy against Streptococcus Pneumonia Photodynamic therapy (PDT) harnesses the combination of light, oxygen, and photosensitizers to induce cell death via reactive oxygen species (ROS) formation. Given its intrinsic properties, PDT repres...

Thrilled to share our article @J_A_C_S on the selection of Ru-modified aptamers. 7 years in the making. Congrats to all authors! Great collaboration with @gassergroup.bsky.social
pubs.acs.org/doi/full/10....
@pasteur.fr @ipdbsc.bsky.social @cnrs.fr @pierrenicolasbizat.bsky.social

⚗️🧪 We are looking for a Postdoctoral Researcher!
Join us at Univ. of Barcelona to apply for Juan de la Cierva–Formación 2025 🧬
💡 Light-activated drugs | PDT | Medicinal Chemistry
🎓 PhD obtained in 2024 or 2025 required
📅 Deadline: Nov 20, 2025
📩 vmarchan@ub.edu
| agandioso@ub.edu

Congratulations Gloria! A fantastic Feature Article on Type I photorreactivity in Ir/Ru complexes - great to see in @chemcomm.rsc.org. Kudos to @MarchanLab_UB, & teams led by Brabec, Sastre, @gassergroup.bsky.social, @kargesgroup.bsky.social, Nonell, Frances, @eortegaforte.bsky.social

🎓 Huge congratulations to Dr. Axel Sarmiento Fuentes on successfully defending his doctoral thesis! 🥂

📘 “Peptide and Supramolecular Engineering for Delivery and Molecular Recognition”

Well done, Áxel — we’re proud of you and excited to see where your next chapter leads!

#FondosEuropeos

👏Le groupe du Pr. Gilles Gasser @gassergroup.bsky.social & le Pr. Dan Gibson ont conçu un conjugué métallique à triple action:
💡 photothérapie
⚡ chimiothérapie ciblée
🧬 stimulation immunitaire

➡️ Toutes les infos ici : urlr.me/d8A3ym

@psl-univ.bsky.social

🚨 PhD Opportunity @UMU! Join a 4-year funded FPI project on light-activated metallodrugs for cancer therapy. Start: Jan 2026 | Deadline: Oct 15, 2025 📧 Contact: jruiz@um.es 📎 PDF attached – official link coming soon! #PhDOffer #CancerResearch #FPIContract #UMU #ChemistryJobs

Group picture at ISBOMC25

Group picture at ISBOMC25 in Chimie ParisTech Library

What a beautiful sunny day in Paris, perfect for a group picture! (@chimieparistechpsl.bsky.social Library is also a nice setting for an inside group picture).

#PhDposition #OrganicChemistry #ChemBio - deadline 03.08 - please RT ❤️ Application online stellenangebote.uni-marburg.de/jobposting/d...

🚨 We are looking for highly motivated postdocs to apply for a MSCA in our group at Universitat de Barcelona! @ub.edu
Join us to develop light-activated drugs for photodynamic therapy & bioimaging 🔬💡
👉 Apply before July 9th!
📧 vmarchan@ub.edu | agandioso@ub.edu
🔗 More info below
#PostdocPosition

Looking for the perfect read for a ☀️weekend? Marco’s latest Angewandte paper is now online and ready to download! 🤩😎❤️ We stabilized HIF1alpha under normoxia conditions photocontrolling downstream events (VEGFA expression)
We hope you enjoy it as much as we do onlinelibrary.wiley.com/doi/epdf/10....

Photography of Dr. Núria Lopez-Bigas

Dr. Núria López-Bigas, Head of the Biomedical Genomics lab at #IRBBarcelona and #ICREA Research Professor, has been awarded the prestigious Rei #JaumeI Award in the category of Medical Research.

Congratulations @nlbigas.bsky.social! 🥳

Read the full news here 🔗 tinyurl.com/3abda75b

BioCiudadReal2025 has come to an end! 🧪🇪🇸🧬 A fantastic opportunity to reconnect with the Spanish bioinorganic community. A meeting of outstanding scientific quality, with excellent talks, vibrant discussions, and exciting perspectives for the future. Looking forward to what comes next! ✨ #AEBIN

José Luis Mascareñas, Premio Rei Jaume I en Investigación Básica El investigador del Centro Singular de Investigación en Química Biológica y Materiales Moleculares (CiQUS) y catedrático de la Universidade de Santiago de Compostela (USC), José Luis Mascareñas Cid,

🎖 𝗝𝗼𝘀é 𝗟𝘂𝗶𝘀 𝗠𝗮𝘀𝗰𝗮𝗿𝗲ñ𝗮𝘀, 𝗣𝗿𝗲𝗺𝗶𝗼 𝗥𝗲𝗶 𝗝𝗮𝘂𝗺𝗲 𝗜 2025 𝗲𝗻 𝗜𝗻𝘃𝗲𝘀𝘁𝗶𝗴𝗮𝗰𝗶ó𝗻 𝗕á𝘀𝗶𝗰𝗮

El investigador del CiQUS José Luis Mascareñas ha sido distinguido con uno de los galardones científicos más prestigiosos del país por sus trabajos en 𝗹𝗮 𝗳𝗿𝗼𝗻𝘁𝗲𝗿𝗮 𝗲𝗻𝘁𝗿𝗲 𝗹𝗮 𝗾𝘂í𝗺𝗶𝗰𝗮 𝗼𝗿𝗴𝗮𝗻𝗼𝗺𝗲𝘁á𝗹𝗶𝗰𝗮 𝘆 𝗹𝗮 𝗯𝗶𝗼𝗹𝗼𝗴í𝗮 𝗰𝗲𝗹𝘂𝗹𝗮𝗿.

A big 🙏🏼GRACIAS🙏🏼 to #JoseLuisMascareñas from @ciqus.bsky.social - our wonderful president of 58 Bürgenstock conference 🇨🇭🧪⚗️ for the fantastic program & bringing the warm Spanish touch! ❤️❤️What a magic week ✨🪄! Great to meet the Spanish crew 😉❤️ #bc_scs25

⚗️✨ Exciting breakthrough! A new family of light-activated drugs offers hope against aggressive cancers like glioblastoma. Proud to be part of this project and to collaborate with such a brilliant team! @ub.edu -@MarchanLab_UB
🔗 www.fbg.ub.edu/en/news/new-...

‼️🔬⚗️🧫🧬🏰 Great opportunity!!

Thrilled🤩🤩to share our latest collaboration with #JanSchuller just dropped in Nature!🎉🎉 Huge shoutout to Fidel & all authors; from us 🙌🏿🙌🏿 #FrankAbendroth drived this forward🚀Inspiring science, great vibes & shared vision in #LovelyMarburg 🏰♥️ @synmikro #micros4clima

Cheers to our Anita 🧑🏿‍🔬for successfully defending her master thesis on photocaged peptide nucleic acids!🍾🥂💐Big 🙏🏼 to @agandioso.bsky.social for 1st🖐🏼supervision & support❤️. Well-done Anita! 🙌🏼🙌🏼
#ChemBio #ProfLife

🧪📣❗ #PhDPosition to develop light-activated drugs for cancer phototherapy. We are seeking candidates with a strong background in #OrganicChemistry #ChemBio and #MedChem to apply for FI-STEP predoctoral fellowships #PDT #Metallodrugs #ScienceJobs

🎯 Coordinado por José Luis Mascareñas, el equipo del proyecto se centrará en el desarrollo preclínico de un prometedor compuesto químico para hacer frente a las 𝗰é𝗹𝘂𝗹𝗮𝘀 𝗺𝗮𝗱𝗿𝗲 𝗱𝗲 𝗰á𝗻𝗰𝗲𝗿.

#CiQUSnews | Investigadores del CiQUS lideran un nuevo proyecto del Consejo Europeo de Innovación para desarrollar un novedoso agente anticáncer.

👉 www.usc.es/ciqus/es/not...

#CienciaCIGUS #FondosEuropeos

Systematic study of hybrid triplex topology and stability suggests a general triplex-mediated regulatory mechanism Abstract. By combining in silico, biophysical, and in vitro experiments, we decipher the topology, physical, and potential biological properties of hybrid-

🚀 Happy to see our new paper in #NAR @narjournal.bsky.social ! 📜🔬 During my postdoc at @irbbarcelona.org , we systematically studied hybrid triplex topology and stability, suggesting a general triplex-mediated regulatory mechanism. 🧬✨ #TriplexDNA #GeneRegulation academic.oup.com/nar/article/...

Incredible days!🎉As the cherry on top, Valeska👩🏼‍🔬1st paper is out—right after her fantastic presentation at #EPI2025 Exciting new collaborations in Marburg with #CrispinLichtenberg & #MarinaGerhard -many more to come. A huge♥️🙏🏼for making it possible! #ProfLife #ChemBio

It has been an absolute pleasure to organize #ySMIN2025! ⚗️ 🧪 Huge thanks to all the incredible speakers for sharing their outstanding science. Your contributions made this event truly inspiring! 👏🔬 #MolecularImaging #Science #EMIM2025

Our Valeska👩🏼‍🔬delivering her fist talk 🗣️in an international conference 🛰️ - I cannot imagine a better scenario for her debut #EPI2025 - Fantastic talk #proudPI 🤩😍 Stay tuned - cool results are coming 😎🚀 Thanks @montenegrolabo.bsky.social & #AnaPina

Deadline #PhD position extended until 09.03 - Apply online👇🏼
stellenangebote.uni-marburg.de/jobposting/3...
Please RT❤️ - Thanks

🔝🚀Excited to have attended an inspiring talk by Pablo Rivera Fuentes @locbp.bsky.social from the University of Zurich on 'Chemigenetic Tools for Imaging and Sensing.' 🧬⚗️🧪Such a fascinating session on how cutting-edge tools are shaping the future of chemical sensing and imaging! @ub.edu