Heading home after a fantastic cannabinoid GRC meeting organised by @drjkhokhar.bsky.social and Cecilia Hillard. Hope to see you all in Dijon ICRS-meeting June 28th -July 2nd, 2026 @icrsonbluesky.bsky.social
22.08.2025 18:36 β π 5 π 2 π¬ 0 π 0
Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474
A drug that was unexpectedly neurotoxic in a clinical trial has off-target activities in chemical proteomic assays.
It also highlights work by the group of @mvdstelt.bsky.social of the @led3hub.bsky.social on profiling the targets of BIA 10-2474 (www.science.org/doi/10.1126/...) as well as the work that @mads-chem.bsky.social performed in Ben Cravatt's lab on JAK1 inhibitors (www.nature.com/articles/s41...) (4/5)
02.07.2025 08:36 β π 3 π 2 π¬ 1 π 0
Probing the proteome - Nature Biotechnology
Chemical proteomics has brought rigor to covalent drug discovery and drugs to the clinic. Can it deliver a new generation of drug targets?
A new exciting article in @natbiotech.nature.com highlights the power of chemical proteomics to find druggable pockets on difficult high-value targets. Great insights into applications in covalent and non-covalent drug discovery including clinical development. (1/5) www.nature.com/articles/s41...
02.07.2025 08:36 β π 23 π 8 π¬ 2 π 0
A great talk by Joel RΓΌegger of the group of @mvdstelt.bsky.social at #FocusOnCovalentDrugs. He talked about his amazing work in the @led3hub.bsky.social on the CellEKT platform for profiling target engagement of kinase inhibitors in living cells. (1/5) www.mcponline.org/article/S153...
10.04.2025 07:53 β π 8 π 2 π¬ 1 π 0
Lipidation of proteins has diverse essential roles in biology.
In his amazing keynote lecture at #Lunteren, Marc Baggelaar talked about his group's exciting contributions to better understand protein lipidations using #ChemicalProteomics. (1/5)
#chemsky #ChemBio
25.03.2025 11:58 β π 11 π 4 π¬ 1 π 0
The Continuing Crisis, Part VII: An Overview
Another βContinuing Crisisβ post, this one covering some larger principles and explaining why Iβm doing these in general:
05.03.2025 18:08 β π 71 π 26 π¬ 6 π 9
Congratulations and a big thank you to @verenas.bsky.social and the labs of Istvan Katona, Yulong Li, Nephi Stella, and Laura Heitman, Coen van Hasselt at @led3hub.bsky.social and @unileiden.bsky.social for a fantastic collaboration. 4/4
21.02.2025 14:34 β π 5 π 1 π¬ 0 π 0
Mathematical modelling provided a comprehensive understanding of endocannabinoid signaling. The model addresses key questions in the field and suggests that microvesicles carrying signaling lipids in their membrane regulate neuronal functions in parallel to synaptic vesicles. n/3
21.02.2025 14:34 β π 2 π 0 π¬ 1 π 0
Our findings led us to propose an βon demand releaseβ model, where microvesicle formation governs endocannabinoid release. This model reconciliates three previously proposed hypotheses for endocannabinoid trafficking. n/2
21.02.2025 14:34 β π 2 π 0 π¬ 1 π 0
Happy to announce on my first bsky post that today our manuscript βThe endocannabinoid 2-arachidonoylglycerol is released and transported on demand via extracellular microvesiclesβ has been published in its final form in PNAS n/1
21.02.2025 14:34 β π 18 π 3 π¬ 5 π 1
Associate Professor, CRC in Translational Neuropsychopharmacology, Open-Source Tools! Committed to knowing better and doing better!
Canadian π¨π¦ Neuroscientist all things Stress, Endocannabinoids and Cannabis
Horror Movies / Weightlifting / Food and Travel / Dogs
Professor of Neurobiology at Columbia Psychiatry. Director of the Cannabis Research Laboratory. Placebo-controlled studies are my favorite.
Neuroscientist. All (bad) opinions are my own.
Addiction Psychiatrist
Assistant Professor of Psychiatry @Yale
I study the neurobiology of addiction and ptsd. My focus is cannabinoids and psychedelics.
I love hiking, skiing, reading, traveling, and working!
Pharmacologist. Trialist. Mom. Associate Prof @umanitoba Perinatal-Child Health Drug Safety & Effectiveness #opioids #medicalcannabis #MedsinMilk she/her
NIAAA K99/R00 Scholar | Assistant Professor @ the University of New Mexico Department of Psychology #NewPI | NIH UNM FIRST Program | Former Besheer Lab Besheerio Postdoc @ UNC SOM Center for Alcohol Studies π©π½βπ¬π§ π§ͺ
π§ π Human behavioral pharmacology lab at π¨π¦ UCalgary studying cannabinoids + psychedelics as novel mental health treatments
PI: @mayoonthebrain.bsky.social | pactlab.ca
Alcohol use clinical trial: https://forms.office.com/r/ccabzTDZH9
Director of Addiction Institute & Chair of Translational Neuroscience
at the Icahn School of Medicine at Mount Sinai. PI of the Hurd Lab. Research on genes x environment x addiction. Working to #EndStigma
labs.neuroscience.mssm.edu/project/hurd-lab/
π§ Developmental neuroscientist at @waynemedicine studying childhood trauma, endocannabinoids, & youth mental health. Let's connect: https://msha.ke/wsuthinklab
Artist, Assistant Prof of & MD Psychiatry at Yale University and Howard University | Decoding social representations & making music, mindfulness & psychedelic tools for connection & mental health https://www.azalab.org/
Pain and Addiction Neuroscientist and Pharmacologist
Pharmacologist focused on effects of cannabis / cannabinoids. Director of UCLA's Center for Cannabis and Cannabinoids
Neuroscientist and cannabinoid researcher.
Director, Center for Cannabinoid Research.
Professor of Biomedical Sciences.
lujanlab.org | Neuroscientist. Assistant professor (TT), LujΓ‘n Lab at UIC. Dopamine, endocannabinoids, systems neuroscience | Soccer & blue guitars.
substance use/cannabis and trauma/stress + genetics/epigenetics + statistics + r programming.
associate professor at unm and casaa.
views are my own.
Peking University, neuroscience, endocannabinoid
Post-doctoral fellow in the lab of Dr Didier Jutras-Aswad at the CRCHUM, Universite de Montreal, Canada.
Researching all aspects of the non-therapeutic use of cannabis.