JAC-AMR

Aztreonam/avibactam is a potential therapeutic option for difficult-to-treat infections caused by MBL-producing Gram-negative bacteria:
doi.org/10.1093/jaca...
#JACAMRNews #IDSky

Retrospective, single-centre study of adult patients with monomicrobial, uncomplicated BSI caused by AMP- or AMX-susceptible Streptococcus or Enterococcus:
No significant difference in 90-day all-cause mortality between oral switch & IV therapy groups
doi.org/10.1093/jaca...
#JACAMRNews

Map showing the global distribution of meropenem resistance rates, as described in Boutzoukas & Doi, The global epidemiology of carbapenem-resistant Acinetobacter baumannii, JAC-Antimicrobial Resistance, Volume 7, Issue 4, 2025, dlaf134, https://doi.org/10.1093/jacamr/dlaf134

Boutzoukas & Doi review carbapenem-resistant A. baumannii, a top-priority pathogen with high mortality, rapid hospital spread, limited treatments and global impact
doi.org/10.1093/jaca...
#JACAMRNew #IDSky #GlobalEpidemiology @davidvanduin.bsky.social

Novel combination therapy using aztreonam, ceftazidime/avibactam and polymyxin B holds promise for tackling persisters in pan-drug resistant K. pneumoniae:
doi.org/10.1093/jaca...
#JACAMRNews #IDSky

The Lodestar DX is a novel point-of-care test for urinary tract infections with strong performance in the detection of common uropathogens:
doi.org/10.1093/jaca...
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Do you work in Primary Care in Greater Manchester or West Yorkshire? We're looking for healthcare professionals to join the pilot of LEAP — BSAC’s new leadership development programme. Please help us spread the word to colleagues who may be interested: ams-leap.com

This study characterized the #AntimicrobialResistance profiles of 3rd generation cephalosporin-resistant & β-lactamase-producing Enterobacterales from poultry
Antimicrobial susceptibility tests revealed high prevalence of multidrug resistance:
doi.org/10.1093/jaca...
#JACAMRNews #IDSky

Are you a UK-based PhD student passionate about #AMR and infectious disease policy? Do you have an interest in public health, environmental health, or the intersection of animal and human health? Applications for BSAC's Parliamentary Internship Programme. Please help us spread the word!

Retrospective analysis of patients with bacteraemic urosepsis shows that treatment with aminoglycosides was as effective as with β-lactams:
doi.org/10.1093/jaca...
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Colistin resistance in Klebsiella pneumoniae, especially MDR, is a growing concern in Africa, complicating patient care and public health:
doi.org/10.1093/jaca...
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Successful use of FEP/zidebactam against K. pneumoniae & P. aeruginosa that developed FDC resistance (the P. aeruginosa was also resistant to FEP/taniborbactam & FDC/xeruborbactam)
The combination of FEP/zidebactam allowed a lifesaving liver transplant
doi.org/10.1093/jaca...
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Swiss study finds a threefold increase in macrolide use among children during global Mycoplasma pneumoniae outbreak in late 2023:
doi.org/10.1093/jaca...
#IDSky #JACAMRNews

Now published – abstracts from the @bsacandjac.bsky.social Spring Conference 2025 👇
academic.oup.com/jacamr/issue...
#JACAMRNews #IDSky #BSACSpring2025

We need to improve communication about AMR & stewardship in animal and agriculture
Ching et al. identified major narratives & weaknesses of current policy discourse, including limited personal relevance & assumption of prior knowledge & universal norms
doi.org/10.1093/jaca...
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Gupta et al. present a case of osteomyelitis with challenges in diagnosing & managing B. pseudomallei, and novel use of levonadifloxacin—a benzoquinolizine antibiotic—as salvage therapy in the context of antibiotic intolerance in a melioidosis patient
doi.org/10.1093/jaca...
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This review of tetracycline-resistant Neisseria gonorrhoeae from 51 countries and 80,645 isolates reported high resistance – meaning using doxyPEP is unlikely to be effective in preventing infections
doi.org/10.1093/jaca...
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Tedizolid, a recent oxazolidinone, shares similarities with linezolid but seems less hematoxic
But this case report shows its brain penetration is low
Caution is advised in using it for neuro-meningeal infections, especially for pathogens with high MICs
doi.org/10.1093/jaca...
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This study highlights the impact of flock-level antimicrobial use on the abundance of #AntimicrobialResistance genes in a poultry production system typical in LMICs:
doi.org/10.1093/jaca...
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Multidrug-resistant Gram-negative bacilli have a negative impact on the outcome of cancer patients:
doi.org/10.1093/jaca...
#AntibioticResistance #SolidCancer #JACAMRNews #IDSky

The outpatient Global-PPS is a new, simple tool to measure antimicrobial prescribing in global outpatient settings
doi.org/10.1093/jaca...
#JACAMRNews #IDSky

Study highlights discrepancies in azithromycin susceptibility tests for S. Typhi, advocating cautious interpretation and combo therapy to prevent relapses:
doi.org/10.1093/jaca...
#JACAMRNews #IDSky

This study offers real-world data evaluating the ePlex BCID-FP rapid identification system for yeast and found it was less sensitive than previously reported and infrequently led to de-escalation of antifungals
doi.org/10.1093/jaca...
@josephsassinemd.bsky.social #JACAMRNews #IDSKy

MEM + C/T combination therapy effectively treated P. aeruginosa prosthetic valve endocarditis, showing synergy in blood & biofilms
This offers a safer alternative to traditional therapies, warranting further study in severe Pseudomonas infections
doi.org/10.1093/jaca...
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MRSA (ATCC 43300) was exposed to increasing concentrations of vancomycin, daptomycin and linezolid for 20 days. In vitro derived mutations were similar to clinical strains including the associated phenotypic alterations:
doi.org/10.1093/jaca...
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Azole resistance in Candida species is rising, threatening treatment options. This review explores resistance mechanisms and future antifungal strategies
doi.org/10.1093/jaca...
@mirazrahman.bsky.social #JACAMRNews #IDSky

This systematic review confirms that new BL/BLI combinations help treat diverse infections, but few are on the market. More real-world data is needed. A key challenge is the lack of class B MBL inhibitors—only aztreonam/avibactam is approved:
doi.org/10.1093/jaca...
#JACAMRNews #IDSky

Imipenem potentiated in vitro activity sulbactam-based combinations to a greater extent than meropenem. The benefits of adding a carbapenem were most evident against isolates with PBP3 mutations:
doi.org/10.1093/jaca...
#JACAMRNews #IDSky

Chisanga et al. found high levels of over-the-counter antimicrobial prescribing in Lusaka Province, Zambia, and call for strengthened monitoring
Further studies to examine the reasons for this practice are needed
doi.org/10.1093/jaca...
#JACAMRNews #IDSky

Giuliano et al. report a neutropenic post-BMT patient with AmpC DHA-1 E. coli bacteremia successfully treated with CAZ/AVI CI
WGS and TDM guided therapy, highlighting cephalosporin–BLI as potential alternatives to carbapenems
doi.org/10.1093/jaca...
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This systematic review and meta-analysis of randomized controlled trials investigated fosfomycin combination therapy for Staphylococcus aureus bacteraemia or endocarditis:
doi.org/10.1093/jaca...
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