🐀 ⚕ RatPappi ⚕ 🐀

👀

Nonononono don’t drag me back down into my special interest 😭 the novel is sitting on my desk rn and I haven’t drawn phanart in a fat min (still on the brain always tho)

doodle of a brown cat with a heart above her head, laying on her belly with her hands on her chin and kicking her feet in the air behind her

Still thinking about The Phantom Of The Opera... Back on my bullshit

ABSTRACT The oral cavity is an accessible site for vaccination, but its sublingual and buccal sites have limited vaccine uptake. Here we show that flat tape dental floss can deliver vaccines through the junctional epithelium of the gingival sulcus, exploiting its naturally leaky properties. Floss-based vaccination delivered protein, inactivated virus, peptide-presenting immunogenic nanoparticles and messenger RNA. In mice, gold nanoparticles functionalized with a peptide derived from the ectodomain of the transmembrane matrix 2 protein of human influenza virus stimulated local lymph nodes, increased CD4+T cells in lymph nodes, lungs and spleen, and boosted antibody-secreting cells in the bone marrow. Floss-based immunization induced strong and sustained immune activation across multiple organs, robust systemic and mucosal antibody responses, and durable protection against lethal influenza infection, independent of age, food and liquid consumption. Floss-based vaccination was superior to sublingual and comparable with intranasal vaccination. In human participants, fluorescent dye delivered via floss picks effectively reached gingival sulcus, supporting clinical feasibility. These findings establish floss-based vaccination as a simple, needle-free strategy that enhances vaccine delivery and immune activation compared with existing mucosal immunization methods.

We acknowledge the support provided by the National Institutes of Health. H.S.G. discloses support for the research described in this study from the National Institutes of Health (grant no. R01AI137846), the National Institutes of Health (grant no. R01DE033759) and the Whitacre Endowed Chair in Science and Engineering. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. We also thank C. Roseburd Magezi Ndamira, a graduate student of Gill lab at TTU, for her help in capturing Supplementary Movie 1.

This method of vaccine delivery is effective because the areas of gum between the teeth are highly permeable, allowing them to absorb vaccine molecules easily.

The study has been published in Nature Biomedical Engineering. YES, it is PEER-REVIEWED.
• www.nature.com/articles/s41...

HOW COOL IS THIS? Researchers have developed a DENTAL FLOSS that can DELIVER vaccines THROUGH the gums, a method that could one day offer a NEEDLE-FREE alternative for vaccination. This approach effectively stimulated immunity AND provided FULL protection against a lethal strain of influenza. 🧪🧵⬇️

"no sex scenes unless it serves the plot" the plot is I want to see them fuck nasty and that's actually legal

You belong where you’re valued ⭐️

#Art #Furry

I remember working part time in a pub and illustrating for maybe one client a month when I started out and I lived like a fucking king. Now I have to work a hundred projects at once to afford like…food. Anyway I think we should ki

The mantis looks strained and upset over a bright red text that reads "TITS BANNED"

🔴 LIVE!

It's a terrible day for throwable item enthusiasts...

spacemantis.live

An anthropomorphic character based off of a fishing lure with a fire tiger coloration

A very a-LURE-ing character I got to design!

Finished up this project! Hands to complete puff the badger my beloved @puffin-badger.bsky.social

#fursuit #fursuitmaker #badger #americanbadger #costume #sewing #paws

rattober 26

1.1 whiskers patch

cave rats

comm for @zunelhak.bsky.social

another comm for @ratm0de

comm for @foxjump

to everyone who contacted me for commissions, you can also get a sketch page for the same price as a standard full color drawing

Doing a pronoun circle with all the other people stuck with me in the Saw trap

A pet rat standing up inquisitively next to the caption "This user supports rats and their sublime agenda. Rodent haters unfollow immediately"

Burnout is clinically understood as a combo of 6 factors—work overload, lack of control, insufficient rewards, breakdown in community, absence of fairness, & value conflicts—and only a fraction of it is under your control. Burnout is a systemic problem, so be kind to yourself and hard on the system.