Nitzan Shabek

UC Davis has a Designated Emphasis in Biotechnology that allows students to engage with industry professionals deb.ucdavis.edu. We also have shadowing programs that allow grad students to interact with and advise leadership grad.ucdavis.edu/CGPSA.

Proposed model: ASK1 integrates the plant stress-responsive proteome by dynamically transitioning from ABA-driven signaling networks to drought-induced proteostasis assemblies, functioning through both SCF E3 ligase–dependent and independent mechanisms.

Our proximity labeling and quantitative proteomics suggest that ASK1/SKP1 assembles condition-specific networks, acting both within SCF E3 #ubiquitin ligases and through noncanonical interactions to coordinate #plant stress adaptation

Dynamic ASK1 proximity networks uncover SCF-dependent and noncanonical roles in ABA and drought adaptation Plants rely on rapid proteome remodeling to withstand fluctuating environmental conditions, yet how the ubiquitin system dynamically coordinates these multilayered responses remains unclear. Here we d...

Excited to share our latest work to close out 2025: Dynamic ASK1 proximity networks uncover SCF-dependent and noncanonical roles in ABA and drought adaptation🌱 With @justinwwalley.bsky.social , we map how ASK1/SKP1 dynamically rewires protein networks during stress www.biorxiv.org/content/10.6...

Dynamic ASK1 proximity networks uncover SCF-dependent and noncanonical roles in ABA and drought adaptation Plants rely on rapid proteome remodeling to withstand fluctuating environmental conditions, yet how the ubiquitin system dynamically coordinates these multilayered responses remains unclear. Here we d...

Excited to share our latest work to close out 2025: Dynamic ASK1 proximity networks uncover SCF-dependent and noncanonical roles in ABA and drought adaptation🌱 With @justinwwalley.bsky.social , we map how ASK1/SKP1 dynamically rewires protein networks during stress www.biorxiv.org/content/10.6...

An emerging signaling hub: KAI2 at the nexus of phytohormone networks KAI2 signaling has emerged as a central integrator of plant hormonal networks, coordinating growth and stress responses despite the continued mystery surrounding its endogenous ligand. This review sy...

📚New 𝐅𝐨𝐜𝐮𝐬𝐞𝐝 𝐑𝐞𝐯𝐢𝐞𝐰:

🌱An emerging signaling hub: KAI2 at the nexus of phytohormone networks🌱

Highlights KAI2 as an integrator of plant hormone signaling, despite its unknown endogenous ligand.

✍️By Jacob Moe-Lange and Nitzan Shabek
@shabeklab.bsky.social

Read it here👉
doi.org/10.1111/tpj....

Was super excited to host @shabeklab.bsky.social in Tel Aviv for the first time since starting my position here and to hear all about the cutting-edge science his lab has been up to since we parted ways! Truly inspiring talk. ✨🤩💪🌱 @ucdavis.bsky.social @telavivuni.bsky.social

An emerging signaling hub: KAI2 at the nexus of phytohormone networks KAI2 signaling has emerged as a central integrator of plant hormonal networks, coordinating growth and stress responses despite the continued mystery surrounding its endogenous ligand. This review sy...

An emerging signaling hub: KAI2 at the nexus of phytohormone networks

onlinelibrary.wiley.com/doi/10.1111/...

excited to be part of this study published @pnas.org led by the wonderful Caroline Gutjahr 👏revealing how the GRAS protein RAM1 partners with WRI transcription factors to regulate genes essential for arbuscule formation & nutrient exchange in plant-fungal symbiosis www.pnas.org/doi/10.1073/...

Cell-autonomous innate immunity by proteasome-derived defence peptides - Nature Proteasomal degradation of cellular proteins generate defence peptides constitutively and in response to bacterial infection. Such peptides might provide a source of natural antibiotics that...

Wow! The Proteasome generates antimicrobial peptides that directly affect bacterial membranes #proteostasis
www.nature.com/articles/s41...

🧪what with the demolition of #NIH funded #research, where, dare I ask, are our friends from #bigpharma? y'all good? mooched enough off of public-access NIH-funded research? Stocked up with PhD level scientists who were trained on NIH training grants to tide you over until Academia comes back?

Evolution of interorganismal strigolactone biosynthesis in seed plants Strigolactones (SLs) are methylbutenolide molecules derived from β-carotene through an intermediate carlactonoic acid (CLA). Canonical SLs act as signals to microbes and plants, whereas noncanonical S...

Super excited to contribute to this amazing work on the evolution of interorganismal strigolactone biosynthesis
www.science.org/doi/10.1126/...

'Ubiquitin Lysine-Linkages' from the review 'Ubiquitin: a structural perspective' in Molecular Cell

New to #ubiquitin? Been with it for a while? Either way this review may be for you 🤩

Excited to share our review article in @molcell.bsky.social, diving deep into everything #ubiquitin
Read here 👉: kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F...

@cellpress.bsky.social
@wehi-research.bsky.social

New Phytologist: Vol 244, No 6 <em>New Phytologist</em> is an international journal owned by the New Phytologist Foundation publishing original research in plant science and its applications.

🆕 Our Latest Issue is online now!

📚 nph.onlinelibrary.wiley.com/toc/14698137...

Highlights:
🌱 Announcing the 2024 Tansley Medal winner
🌱 Unravelling plant centromeres
🌱 Is auxin the key to improve crop nitrogen efficiency?
🌱 Vegetation responses to moisture conditions

Excited to share that our research on the SCF E3 ubiquitin ligase interactome in plants is now published in New Phytologist and featured as the cover of the current issue! 🌱 @newphyt.bsky.social #ubiquitin #proteostasis
nph.onlinelibrary.wiley.com/share/CA8XRQ...

I made a starter pack for the plant proteostasis community - please let me know if I missed someone to add new members #proteostasis

The email announcement of International Plant Growth Substances Association (IPGSA) Conference in 2025 in Fort Collins, Colorado, USA is just out! Please spread the word of what will be a very exciting conference in a beautiful place. #IPGSA2025

Single‐cell proteomics differentiates Arabidopsis root cell types See also the Commentary on this article by van Schie & Weijers, 244: 1678–1680.

Final version of or single-cell proteomics paper is now published in the New Phytologist December issue! @dormichicken.bsky.social
nph.onlinelibrary.wiley.com/doi/10.1111/...

Structural insights into strigolactone catabolism by carboxylesterases reveal a conserved conformational regulation Nature Communications - Plant hormone levels are regulated by synthesis and breakdown, but the mechanism of strigolactone degradation remains unclear. This study reveals the structure of distinct...

our latest work @natureportfolio.bsky.social nature communications: Structural insights into strigolactone catabolism by carboxylesterases reveal a conserved conformational regulation
rdcu.be/d0s6l

Bacteria conjugate ubiquitin-like proteins to interfere with phage assembly - Nature To mitigate&nbsp;phage infection, an antiphage defence system in bacteria conjugates a ubiquitin-like protein to a structural&nbsp;protein of&nbsp;the phage, demonstrating that conjugation of ubiquiti...

Should've done this a long time ago, but here's my first post on #Bluesky.

Check out my postdoc paper on a bacterial ubiquitin-like defense system that we recently published!

www.nature.com/articles/s41...

Check out this list of ubiquitin and Ubl profiles to follow. Repost if you want me to add you to it. Let’s create a good community here ☁️ go.bsky.app/3VPQofn

I direct the UC Davis Biotechnology Program - looking forward to building #academicsky community! 🧬🧫🔬🧪🥼#ucdavis #biotech

Structural insights into strigolactone catabolism by carboxylesterases reveal a conserved conformational regulation Nature Communications - Plant hormone levels are regulated by synthesis and breakdown, but the mechanism of strigolactone degradation remains unclear. This study reveals the structure of distinct...

our latest work @natureportfolio.bsky.social nature communications: Structural insights into strigolactone catabolism by carboxylesterases reveal a conserved conformational regulation
rdcu.be/d0s6l

Mechanistic study of SCOOPs recognition by MIK2–BAK1 complex reveals the role of N-glycans in plant ligand–receptor–coreceptor complex formation Nature Plants - Wu et al. elucidate the molecular basis for SCOOPs perception by the MIK2–BAK1 immune complex and demonstrate an unexpectedly pivotal role of N-glycans in plant...

molecular basis of SCOOP perception by the MIK2–BAK1 immune complex rdcu.be/d0s5E