Vibhu Prasad

Excited to share our latest work on how viruses “rewire” the cell division machinery of infected cells.

Investigating viral strategies provides insights into how key cellular processes are controlled, and where they can fail.

#CellBiology #Virology #Cytokinesis #APCC #GenomeStability #Adenovirus

The question of the origin of #SARS-CoV-2 is a matter of significant scientific and public interest. Current publicly available data suggests a natural origin, while evidence supporting a lab origin remains scarce. Although no hypothesis has been definitively proven, the available data indicate...

‼BREAKING‼
We’ve secured new funding for the Boston Bioimage Analysis Course (BoBiAC) this July at Harvard Med School! Course fees down 37%, with fee waivers for academic applicants, for an intensive hands-on intro to bioimage analysis with Python!

Apply by June 1st!
iac.hms.harvard.edu/bobiac/2025

Importin-9 and a TPR domain protein MpH drive periodic patterning of ciliary arrays in #Tetrahymena, say Anushi Suwaneththiya Deraniyagala, Wolfgang Maier, Jacek Gaertig @universityofga.bsky.social and colleagues: rupress.org/jcb/article/...

#Cilia #Development

Transmission of unfolded protein response—a regulator of disease progression, severity, and spread in virus infections | mBio The unfolded protein response (UPR) is a cellular stress response pathway activated by the accumulation of misfolded or unfolded proteins in the endoplasmic reticulum (ER) (1). The UPR aims to restore...

ER stress in cells (cell-autonomous) can be transmitted to neighbouring unstressed cells to generate a broader systemic ER stress response (cell non-autonomous ER stress) and hence have a wider impact in an organism where the stress was initially induced. Its significance to virus infections! 👇🏽

Endothelial inflammation in COVID-19 Disrupted endothelial function underlies the multiorgan complications of COVID-19

Infection with #SARSCoV2 has highlighted how altered endothelial functions contribute to multiorgan health effects during the acute phase of #COVID19 and potentially to the longer-term consequences associated with #LongCovid.

Learn more in a new #SciencePerspective:

We focused on a biological process shared between the 2 tissues: the unfolded protein response (UPR). Both tissues become highly secretory but make different cargoes. Cells activated the UPR prior to cargo production, suggesting developmental anticipation of future stress. (5/)

Poster of key discoveries in virology, starting in 1796

Viruses are therefore important: they affect all life on earth. They themselves also change, as we now notice with #SARSCoV2 who has made the leap to humans. Viruses can sometimes even determine what will survive. Don't underestimate these little bundles of information.

Regulatory interactions between APOBEC3B N- and C-terminal domains biorxiv.org/cgi/content/short/2024.12.11.628032v1

Submit your research abstracts for the 34rd Annual Meeting of the Society for Virology before it's too late. You only have a little more than a week left! Deadline is 1 December!

🔗 virology-meeting.de/registration...

#GfV #GfV2025 #virology #virologymeeting #virus #viruses