Arif

Illuminating microbial dark matter: Dietary alterations uncover microbial regulation of immunity and metabolism Dietary alterations uncover microbial regulation of immunity and metabolism

Honored and delighted to be a runner-up for the 2025 NOSTER & Science Microbiome Prize and join the ranks of the recipients! Thanks to Noster Inc. and @aaas.org for this recognition! Here is my essay highlighting our research program in this issue of @science.org. www.science.org/doi/10.1126/...

#postdoc opportunity in #immunology and #microbiome research at Weill Cornell Medicine - Cornell University in New York City! For details about the position see the image below. For details about the lab: robertsinstitute.weill.cornell.edu/arifuzzaman-...
Please share!

We are hiring a #postdoc and a research technician at Weill Cornell Medicine - Cornell University in New York City! We study the impact of diet and gut microbiota on inflammation, immunity, metabolism, and cancer. Join us if you are interested in #immunology and #microbiome research.

Diet, microbes: new pathway controlling levels of body fat, cholesterol | Cornell Chronicle Beneficial gut microbes and the body work together to fine-tune fat metabolism and cholesterol levels, according to a new preclinical study by investigators from Weill Cornell Medicine and the Boyce T...

Diet, microbes: new pathway controlling levels of body fat, cholesterol. news.cornell.edu/stories/2025.... Full story @nature.com: rdcu.be/d6mIi

Thank you Pieter! A lot more to do in coming days!

Host metabolism balances microbial regulation of bile acid signalling Nature - A family of host-derived bile acid–methylcysteamine conjugates functions as FXR antagonists, forming part of a microbiota-dependent metabolic network that regulates FXR-dependent...

While microbial metabolites are known to influence host physiology, this study provides a glimpse into the mechanisms of our co-evolution and symbiosis. This new group of bile acid conjugates may help reduce cholesterol levels, with implications for liver disease. Full article: rdcu.be/d5VUz

Host metabolism balances microbial regulation of bile acid signalling - Nature A family of host-derived bile acid–methylcysteamine conjugates functions as FXR antagonists, forming part of a microbiota-dependent metabolic network that regulates FXR-dependent physiology.

In this issue of @nature.com, we identified a new class of molecules: host-modified microbial metabolites. While microbial bile acid metabolites are FXR agonists, we show that the host can modify them into antagonists, therefore balancing microbial signaling. www.nature.com/articles/s41... 1/2