Kaitlin

Sort of funny now that I think about it how the cult of linear algebra nerds can be so confident sometimes that things can be described with scalar quantities. Almost no rhyme or reason to when or why

Out today: We discovered new viral proteins that target immune signaling molecules, solely based on their AlphaFold-predicted shapes

www.science.org/doi/10.1126/...

Congrats Nitzan Tal and coauthors! Thank you Kranzusch lab for the fun collaboration!

Linking below previous thread on our findings

I’m sick just thinking about it

the web is a customer service medium, thats why its so unpleasant imo

like trying to have a good time with the other people in line to return a defective vacuum and a yeti rambler to target

Why would I try

Everybody thinks that everybody else understands linear algebra better than they do

Ime anything that starts with “undergraduate linear algebra tells you” and ends with something people care about should be a paper. Linear algebra is where the Common Knowledge caps out currently

[channeling cosma] most priors are smoothing

They will give Kaitlin computer 😈

It’s rumored that I am in NYC

Ali Khamenei, Iran’s Supreme Leader, Killed in US-Israel Strikes Ayatollah Ali Khamenei, the supreme leader of Iran who dominated every aspect of the country for more than three decades as it faced off with the West, was killed Saturday after the US and Israel launched airstrikes on Iran, according to President Donald Trump. He was 86.

Ayatollah Ali Khamenei, the supreme leader of Iran, was killed Saturday after the US and Israel launched airstrikes on Iran, according to President Donald Trump. He was 86.

So proud of this work with @rolanddunbrack.bsky.social! Did a lot of new structural bioinformatics of substrate-bound kinases and came up with updated criteria for classifying structures as active. Also made active models of all 437 human catalytic kinases, available here: dunbrack.fccc.edu/kincore

Great work from post-doctoral fellow @joanzone.bsky.social:

New preprint on identifying active structures of protein kinases -- capable of binding ATP, Mg ions & especially substrates -- +modeling all 437 human catalytic protein kinase domains in their active conformation.

doi.org/10.64898/202...

Broke: dead internet theory
Woke: undead internet theory

REAL

I’m always saying this

A friend has managed to host a weekly watch party that has thus far made it all the way through “the evil that men do”

I’d love to read this. Would you be willing to email me a PDF? I can provide my email over DM

hi guys I know I haven't been very active lately, and I don't talk about where I'm from often, but the government made some really scary announcements today so I thought I'd share to let everyone know what's happening. here are some posts from twt for context

Ancient co-option of LTR retrotransposons as yeast centromeres - Nature Evolutionarily related ‘proto-point’ centromeres providing resolution to the evolutionary origins of point centromeres are identified in yeast, and comparison shows they evolved in an ancestor with re...

Our paper is now out in Nature:

“Ancient co-option of LTR retrotransposons as yeast centromeres”

www.nature.com/articles/s41...

A short thread on how retrotransposons helped give rise to yeast point centromeres.

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wtf I did NOT know this

I have yet to see anything more impressive than those side projects programmers used to show off on hackernews but maybe I’m not looking in the right places.

do I have any followers in Canada (Toronto, Ottawa, Montreal) who are academics and think they have anything academic overlap with what I do (complexity and predictive modeling, information theory)? I'm planning a Canada tour and am interested in hitting as many academic centers as possible

endometriosis

What’s the most impressive piece of AI-coded software you’ve seen? Bonus points for comp biophys

theres kind of a fun read of this to do where its about the cost of signifiers: a lot of peoples' wages went down in terms of F-250s

A small polymerase ribozyme that can synthesize itself and its complementary strand The emergence of a chemical system capable of self-replication and evolution is a critical event in the origin of life. RNA polymerase ribozymes can replicate RNA, but their large size and structural ...

How could a simple self-replicating system emerge at the origins of life? RNA polymerase ribozymes can replicate RNA, but existing ones are so large that their self-replication seems impossible. Could they be smaller?

Excited to share our latest work in @science.org on a new small polymerase.
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kresten is cooking this year

best halftime show ever