Nazia Jassim

Proud to be part of this amazing lab which maintains a truly optimal ratio of research papers to Colin the Caterpillars! 🐛🍰🍩

This one was featured in the @natcomms.nature.com editors highlights page - a lovely recognition of the quality and importance of this work. Well done team!

Computational signatures of uncertainty are reflected in motor cortex excitatory neurochemistry - Nature Communications Using computational modelling and neurochemical analysis, this study shows how motor cortex excitatory signals guide belief updating and adaptive learning in uncertain environments.

Then we have a new paper led by Nazia Jassim @naziajassim.bsky.social on the neurochemical markers of uncertainty processing and links to trait anxiety: www.nature.com/articles/s41...

@natcomms.nature.com

The relationship between anxious traits and learning about changes in stochasticity and volatility Author summary Adapting to changes in our environment is a daily endeavour. To do so, humans and animals alike make use of feedback to guide future actions. Uncertainty in the environment can arise fr...

First up, this paper led by Bronagh McCoy: journals.plos.org/ploscompbiol...

When noise and volatility are independently manipulated people behave differently depending on their anxious traits.

This work is now out in Nature Communications! 🎉

Computational signatures of uncertainty are reflected in motor cortex excitatory neurochemistry: www.nature.com/articles/s41467-025-64702-6

Huge thanks to our amazing team! @beckyneuro.bsky.social @campsydept.bsky.social @camneuro.bsky.social

If you're interested in computational psychiatry, come chat with me about the neurochemical markers of uncertainty processing at poster A10 #BAP2025

Exciting guest lecture by Angela Roberts on anhedonia and anxiety #BAP2025

Thrilled that this work from my PhD and postdoc is finally out in preprint form. It’s been several years in the making and I couldn’t be more grateful for such an amazing team of collaborators to help bring it to the finish line!

We also looked at the above in relation to trait anxiety. Interestingly, both model-free and model-based results indicate that that high trait anxiety was associated with faster responses after the reversal (4/4)

We found that baseline glutamine+glutamate levels in the primary motor cortex M1 correlate with model-based prediction errors & volatility beliefs, suggesting a key neural marker for uncertainty processing (3/4)

To probe the underlying processes, we introduce a novel categorical state-transition extension of the Hierarchical Gaussian Filter (HGF) that tracks beliefs about stimulus transitions in a 4-choice probabilistic serial reaction time reversal learning task. (2/4)

Neurochemical markers of uncertainty processing in humans How individuals process and respond to uncertainty has important implications for cognition and mental health. Here we use computational phenotyping to examine individualised 'uncertainty fingerprints...

New preprint alert! How do we process uncertainty, and how do neurometabolites shape this?🧠Here we combine computational modeling + 7T MRS to answer these questions: www.biorxiv.org/content/10.1...
With Peter Thestrup Waade, Chris Mathys, Frederike Petzchner, @beckyneuro.bsky.social & others! 🧵(1/4)

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