David Clinkard

Watched and thought it was amazing, can’t wait for round 2

Heart failure paradoxically involves both cell growth and death. Imaging single cell dynamics, we found that when stressed, individual cardiomyocytes commit early to either grow or die. #MicroscopyMonday

Artificial intelligence-guided design of lipid nanoparticles for pulmonary gene therapy

www.nature.com/articles/s41...

Super interesting study that suggests exogenous ketones decrease FFA utilization in normal hearts

'Spatial, single-cell, nuclear, and bulk RNA sequencing traced this defect back to the superior cervical ganglia (SCG), which responded to cardiac disease with accumulation of inflammatory macrophages, fibrosis, and the selective loss of pineal gland–innervating neurons.'

As anesthesia I’m biased, but my understanding is they were based on the 25% centile of time. 2- anesthesia is 100 percent dependent on surgical time, slow surgeon = more time. 3 vox is highly subsidized by insurance companies. 4- per hour my plumber makes more than me, I just work a lot of hours

Fingers crossed indeed! Me too!

I backpacked through Syria in 2008 for 2 months. Was a beautiful country with the most welcoming people of anywhere I have traveled before or since. I hope this regime change allows peace for a population decimated by war and that I (selfishly) can return to re-experience the amazing hospitality.

So glad I never have to deal with this here in Canada

The role of acute inflammation in pain resolution: is it time to rethink the use of routine anti-inflammatories in surgical practice? - Canadian Journal of Anesthesia/Journal canadien d'anesthésie Canadian Journal of Anesthesia/Journal canadien d'anesthésie -

Happy to finally publish my comment in CJA - are we really thinking about the long term effects of anti-inflammatories preoperatively?? link.springer.com/article/10.1...