Rebecca Lester

Personalized inhaled bacteriophage therapy for treatment of multidrug-resistant Pseudomonas aeruginosa in cystic fibrosis - Nature Medicine A novel personalized phage therapy strategy that selects phages for a predicted evolutionary trade-off may represent a viable alternative approach for the treatment of antimicrobial-resistant bacteria...

Great paper out by Ben Chan, Jon Koff and co at Yale highlighting compassionate use of phage therapy in nine patients with CF with multi-drug resistant strains of Pseudomonas aeruginosa
www.nature.com/articles/s41...

The gut microbiome and its resistome as predictors of clinical infections and phenotypic antibiotic resistance in hematopoietic stem cell transplant recipients metagenomics to enhance the understanding of infectious sources and to identify patients at risk of clinical infection with antibiotic-resistant bacterial strains.

Beginning to scratch the surface of the microbiome resistome, and what it means for risk of infections and #AMR
#IDSky #ClinMicro
CC @rlester.bsky.social
academic.oup.com/jid/advance-...

Gut microbiome evolution from infancy to 8 years of age - Nature Medicine In a unique cohort of twins followed from birth to 8 years of age, shotgun sequencing of stool samples reveals that the transmission, persistence and evolutionary adaptation of bacterial strains are s...

#NatMicroPicks

Tracking the gut microbiome evolution 🦠

A big data analysis of gut microbiome of kids from infancy to 8 years of age.

#MicroSky #MicrobiomeSky
www.nature.com/articles/s41...

Do women not make outstanding contributions to the world?

Just made a custom feed that pulls in a wide array of hashtags being used at ESCMID Global 2025

May have a few minutes delay, but contains posts with
#ESCMIDGlobal #ESCMIDGlobal2025 #ESCMID2025 #ECCMID2025

Feel free to pin it to your timelines. Hope it's helpful #IDSky

bsky.app/profile/did:...

Absolutely. Epi and surveillance the first step towards improving therapy @gpollara.bsky.social

Come along and listen to our work #ESCMIDGlobal #ESCMID2025 #IDSky

Yeah personally we should drop the word de-escalation. What are we going up or down on anwyay?

The issue is breadth of antimicrobial coverage, measured bluntly by the number of species that you catch within your antibacterial net!

@rlester.bsky.social & I working on this area. Watch this space...

I’ll handle this, @gpollara.bsky.social.

Dr Lester, in my experience it goes Start Smart; Focus; escalated overnight by F1 for a temp of 37.3; de-escalate again; back on IV because AMT 9/10; on orals after 10d IV to finish off; but it’s high dose Cipro obviously and the patient just died of C.diff

Brilliant to have outcomes @gpollara.bsky.social

Start smart, then focus, then what?

#AMS #AMR #IDSky #ClinMicro

Excellent from BSAC

Yes - not sure!

Safety, pharmacokinetics, and pharmacodynamics of LBP-EC01, a CRISPR-Cas3-enhanced bacteriophage cocktail, in uncomplicated urinary tract infections due to Escherichia coli (ELIMINATE): the randomised... The rate of antibiotic resistance continues to grow, outpacing small-molecule-drug development efforts. Novel therapies are needed to combat this grow…

This is very cool phage work. Studies of phage-antibiotic co-administration crucial for understanding impact on AMR.

Time to overcome barriers to phage administration so more work like this can be done 💪 #IDSky

www.sciencedirect.com/science/arti...

Beautiful explainer on the simplicity and stability of Microbiology taxonomy.... 😅
#MicroSky #clinmicro #IDSky 🧪

Health inequalities which impact the treatment of urinary tract infections Find out about this studentship opportunity on Health inequalities which impact the treatment of urinary tract infections.

PhD studentship available.

The project is VERY interdisciplinary, combing social science, biophysics and microbiology to understand inequalities of UTIs treatment and replicate them in vitro to help choose the correct antibiotic.

Pls share, home students only #AMR #MicroSky

tinyurl.com/45d8h54u

I'm sure we would at the Free Michael

Comprehensive Assessment of Initial Adaptation of ESBL Positive ST131 Escherichia coli to Carbapenem Exposure High-risk ST131 E. coli strains, particularly C2/H30Rx subclades, adapt to initial carbapenem exposure by IS-mediated ESBL gene amplification. This gene am

🆕✨Super interesting
How high-risk ESBL-Ecoli initially adapt to carbapenem exposures prior to acquiring carbapenem resistance?
ST131 mutants ▶️Erta exposure 🔼ESBL gene copies via IS26 mediated PCTns or mutations in outer membrane porin(Omp) genes
#idsky #microsky
academic.oup.com/jid/advance-...

Relax people - we have an extra 48hr to submit abstract to @escmid.bsky.social global! #IDSky #ESCMIDGlobal

#Icantgo 😢