Bryony Leeke

The new issue @cp-devcell.bsky.social brings the final form of our opossum heterochrony work www.cell.com/developmenta... And it also brings two great papers from @oliveringe.bsky.social @santoslab.bsky.social and @tobyandrews.bsky.social @rashmi-priya.bsky.social 🙌 great #DevBio from @crick.ac.uk

The position is for someone with the right to work in the UK, as the ideal start date is January.

mrc.tal.net/vx/lang-en-G...

The role might be a good fit if you've finished a PhD/postdoc but aren't ready to move to a longer position yet. Or, if it goes well, the lab can support you to apply for a grant for a longer postdoc on metabolism/pluripotency, since we have preliminary data that could support a proposal.

Join @mpercharde.bsky.social Lab at the MRC LMS! We have an 18mo postdoc position to cover a couple of projects (maternity leave and paper revisions). The projects are focussed on chromatin in early mouse embryos and metabolism in mouse embryonic stem cells and pluripotency.

1/ I’m very excited to share my postdoc work with @kseskv.bsky.social, in collaboration with @oligriffith.bsky.social. We explore embryonic DNA methylation reprogramming in the fat-tailed dunnart, an Australian marsupial 🦘🌏 www.biorxiv.org/content/10.1...

MRC Postdoctoral Research Scientist - MRC Laboratory of Medical Sciences The MRC Laboratory of Medical Sciences (LMS) is a biomedical research institute where scientists and clinicians collaborate to advance the understanding of biology and its application to medicine. LMS...

#JobAlert! We have an opening for a postdoctoral scientist in #CancerMetabolism in my lab @mrc-lms.bsky.social. If you're interested in the role of metabolism in drug response and resistance in cancer, and would like to work in a fun and friendly team, check it out: lms.mrc.ac.uk/work/vacanci...

MRC Postdoctoral Research Scientist - MRC Laboratory of Medical Sciences The MRC Laboratory of Medical Sciences (LMS) is a biomedical research institute where scientists and clinicians collaborate to advance the understanding of biology and its application to medicine. LMS...

The Chromatin And Development lab are hiring a postdoc!

Come join us; we are a happy and hard working team @mrc-lms.bsky.social in London UK. Projects span the intersection of chromatin and transposon biology in dev't and disease. Email/DM for more info. Pls RT!

lms.mrc.ac.uk/work/vacanci...

Cover of issue 9: Neuronal connections in control (left) and Klp61F (kinesin-5) neuronal knockdown (right) Drosophila larval brains, labelled with photoconvertible EOS-tagged tubulin. Spectrum color-coded hyperstacks of z-stack images were used to show the relative spatial positions of neurons within the brain sample. See Research Article by Lu et al.

Issue 9 is complete!

Cover: Neuronal connections in control (left) and Klp61F neuronal knockdown (right) Drosophila larval brains, labelled with photoconvertible EOS-tagged tubulin. Spectrum color-coded hyperstacks of z-stack images show relative spatial positions of neurons doi.org/10.1242/dev....

Figure 1 Nucleolar structure and rRNA gene organisation.

In this Review, @bryonyleeke.bsky.social, Imke Staffhorst and @mpercharde.bsky.social @mrc-lms.bsky.social explore roles of the nucleolus in mammalian development, focusing on genome organisation and chromatin regulation:
doi.org/10.1242/dev....

😂 what are the chances! Thank you for your kind words Joaquina.

nucleoli are dynamically reprogrammed in early mammalian development

The nucleolus....large, rather boring organelle in the nucleus? No! Our review led by @bryonyleeke.bsky.social just out @dev-journal.bsky.social, highlighting new findings on nucleoli dynamics in development, intriguing roles in chromatin organisation & more.

journals.biologists.com/dev/article/...

Marsupial embryos lack the epigenetic reset seen in placental mammals DNA-methylation marks remain stable in early-stage opossum embryos.

You can also read a research briefing about the paper here: www.nature.com/articles/d41...

Happy to say the work from my time in the Turner lab is now published! Check out this thread from the lab account to learn about DNA methylation in marsupial embryos. Massive thanks to all the co-authors!

Divergent DNA methylation dynamics in marsupial and eutherian embryos - Nature A study reports on the DNA methylation dynamics during embryogenesis in marsupials, showing that these differ from those occurring during embryogenesis in eutherian mammals.

We're excited to publish our latest study led by Bryony Leeke @bryonyleeke.bsky.social and Wazeer Varsally, now out in @nature.com 🍾This study focusses on the epigenome of marsupial embryos 🦘 mapping DNA methylation in embryo development to specific embryo events www.nature.com/articles/s41... 🧵

We thrilled to see our latest study led by @jeremie-subrini.bsky.social now out in @science.org 🔬

What are the specific functions of each Y-chromosome gene in fertility ? We generated and studied 13 Y-gene KO mouse models to find out! 🧬

www.science.org/doi/full/10....

❗ANNOUNCEMENT❗
YEN 2025 Conference will be held at @crick.ac.uk on the 19th May 2025.

We are looking forward to another exciting line-up with Nicolas Rivron, Maud Borensztein and Peter Rugg-Gunn.

This year will see a return of the YEN Image Competition so follow for updates.

Share for #YEN2025!