Dr. Foxpaws Fauxpas M.D.

CDK 4/6 inhibitors form the predominant backbone in hormone positive metastatic breast cancer.

A summary of its transformative effect on survivals.

#mbc #bcsm #oncsky #breast #cancer

SABCS 2024 Summary: Key Updates From the EMBER-3, PATINA, TAILORx, INSEMA, and OlympiA Trials in Breast Cancer Management A video from Margaret Gatti-Mays (as part of 2024 SABCS Annual Meeting Insights Hub), posted on Jan 3, 2025.

My take on the #Top5 🔑 studies presented at #SABCS24 for #VuMedi #bcsm #breastcancer @osucccjames.bsky.social @osuwexmed.bsky.social @sabcs.bsky.social

Welcome, happy to help!

One of the most common unnoticed electrolyte imbalance in cancer patients - Hypomagnesemia!

Do test when indicated by keeping it in your DDx !

Here's a quick run through of causes of ⬇️ Mg in Ca pts - especially keep in mind when using:
💊EGFRibs
💉Platins
💊TKIs
💉Anti HER2

#cancer #oncology #oncsky

Antibiotics at increased risk of clostridium difficile infection

Must know for every clinician!

#basics #pharmacology

Revising FLIPI 1 & 2 in follicular lymphomas

Compared with m7 FLIPI - 7 gene Clinicogenetic score - validated in GALLIUM - RCHOP/RCVP

❌ in bendamustine regimens
⚡ EZH2 mutation status

-Bendamustine in EZH2 wild type FL
-CHOP/CVP in EZH2 mutated FL ✅ ⬆️ PFS

#lymsm #lymphoma #oncsky #basics

Revising FLIPI 1 & 2 in follicular lymphomas

Compared with m7 FLIPI - 7 gene Clinicogenetic score - validated in GALLIUM - RCHOP/RCVP

❌ in bendamustine regimens
⚡ EZH2 mutation status

-Bendamustine in EZH2 wild type FL
-CHOP/CVP in EZH2 mutated FL ✅ ⬆️ PFS

#lymsm #lymphoma #oncsky #basics

Here's a fan #art i made of my favorite #christmas movie!

What's christmas without an elf, a dwarf and a magic white bearded grandpa?

😄 Merry Christmas everyone!

4 diagnoses, 4 livers.
1 endless week.

Oncology can be pretty darn humbling.

Currently in a spiral of existentialism and confronting one's own mortality.

How do immuno modulatory agents work in #myeloma?

And why does Pomalidomide work even after progression on lenalidomide?

Tumor microenvironment plays a major role in myeloma and pathogenesis.

Ikarus Transcription factor is key.
#cancer #hemesky #blood #oncsky

@nihardesai7.bsky.social

What clinical features should you pick up as an oncologist in a patient receiving systemic therapy?

#basics #oncology #oncsky

Good to know for medical students and people interested in oncology!

#Liver transplantation criteria for #HCC -

Review from the new ASCO guidelines

#oncsky #oncology #cancer

#cardio toxicity of CML TKIs, multiple myeloma agents and VEGF blockers.

⚠️ VEGFr blockers need more stringent monitoring than anthracyclines and HER2 targeted Mabs!

#cancer #myeloma #oncsky

ICI induced myocarditis ❤️‍🔥
🔬 Patho (EMBx) - Dallas Cx
Multifocal inflammatory infiltrates + overt cardiomyocyte loss

⚕️Clinical
cTn - new/significant ⬆️⬆️ from baseline
- with 1 major/2 minor criteria
- Exclude ACS/acute infectious myocarditis

#sabcs24 #cancer #bcsm #oncsky #cardio toxicity

Trials supporting Immunotherapy in operable NSCLC

Slides courtesy of the incredible Dr Katsuaki Maehara @katsuaki-maehara.bsky.social

#LUNG #cancer #lcsm #oncsky

Management of leptomeningeal disease

💉 Intrathecal therapy
☢️Response assessment criteria
🧬 Promising areas of research
✅ Treatment algorithm

#oncology #oncsky #cns

Actually platins can cross the BBB, however - the amount that it crosses is low.
Tmz and capecitabine can also cross the BBB.

Doxorubicin is not known to cross the BBB.

Quiz time!

Which conventional chemotherapy agents of the below cannot cross BBB?

Capecitabine
Platinums
Temozolomide
Doxorubicin

#oncsky #chemotherapy #basics #brain #oncology

Below is an microanatomic depiction of physiological vs pathological BBB at a microscopic level.

Pearls of #myeloma wisdom from @vincentrk.bsky.social

Quick review algorithm - for transplant eligible and relapsed myeloma

#ash24 #heme #hemonc #oncsky

LEAP program - Lenva and Pembrolizumab in solid tumors

A comprehensive list of LEAP group trials

A summary of site-wise response rates and PFS

Interesting paper!
#oncology #oncsky #lcsm

www.tandfonline.com/doi/full/10....

⚡ Doses and indications of lenvatinib - for all FDA approved indications.
Along with dose reduction levels
A quick reckoner
Common Tox:
☢️Diarrhea
☢️Asthenia & mucositis
☢️Proteinuria & HTN
☢️Rash and PPE

#oncsky #chemotherapy #basics #oncology

@vincentrk.bsky.social

Welcome to bluesky, my favorite myeloma/hematology teacher 🙏

Hi, tried registering for the virtual attendance - have not gotten a confirmation email yet 😔

Is there something I'm doing wrong?

Was brushing up a bit about myelodysplastic syndromes.

Came across a concise & brilliant article by Dr Garcia Manero - must read!

Prognostication, cytogenetics in MDS, the MDS spectrum, treatment algorithms and the IPSS stratification.

#heme #hemonc #oncsky

Opinion: Colostomy free survival would be a very good surrogate marker of QOL for ca rectum.
Especially with so many younger patients these days.
Their HRQOL and sexual QOL will also come into play with locoregional recurrence. Organ preservation should be our next great frontier.

#oncsky #cancer

TCGA - Gastric Ca Molecular Classification
👁️ EBV - best outcomes following resection, notably absent in GEJ
❌ GS- Lauren Diffuse-poor outcomes, poor chemoresponse
🧬 CIN - Lauren Intestinal - benefit of adj chemo ⬆️

Snapshot of targeted therapies for Gastric adenoca

#gi #gastro #cancer #oncsky

Diminishing returns specifically with these two malignancies, i mean

Lest anyone mistakes me 😅

I feel like RT is perfect for cervical and HNSCC - especially locally limited ones. It offers the best possible outcomes - avoiding systemic toxicity.

Chemotherapy and targeted therapy has reached the point of diminishing returns for now. Should devote time designing trials with RT as backbone.

We generally only give a low dose of Prednisone with Abiraterone.

Conventional tapering over 3-4 days should be sufficient - from our clinical experience.

Trying very hard to break the hold of radiation in HNSCC. Don't think it's practically possible in this decade.