@MorieLAB

Human MX1 orchestrates the cytoplasmic sequestration of neosynthesized influenza A virus vRNPs | PNAS Interferon-inducible Myxovirus resistance 1 (MX1) proteins are known to restrict influenza A virus (IAV) transcription/replication process. Herein,...

After years in the making, Joe McKellar @viroscope.bsky.social’s final PhD paper is finally out today in PNAS! 🎉 🎉🎉
www.pnas.org/doi/10.1073/...

Big congratulations! MicroPublication is a so valuable initiative to inform the community of accomplished work that will save time and effort to other researchers! I am superhappy to see you joined this initiative! Congratulations to Louison! 🎉

Massive congratulations, Felipe! This work is a gigantic endeavour! And a fantastic resource! Mechanistically, is the absence of Homologous Recombination intrinsic to the pathways dictated by using Cas9 to create the cut? In S. cerevisiae Cas9 cuts very efficiently engage HR. Felicidades de nuevo! 😍

Nuclear mechanics as a determinant of nuclear pore complex plasticity - Nature Cell Biology In this Review, Lusk et al. discuss emerging insights into nuclear pore complex variability with regard to composition and dilation state, and propose nuclear mechanics as a key determinant of driving...

Did you know that all nuclear pore complexes (NPCs) are not the same? @luskinglab.bsky.social propose a new hypothesis for how nuclear mechanics may impact the compositional plasticity of NPCs with implications for tissue-specific diseases caused by NPC dysfunction.

www.nature.com/articles/s41...

A significant conceptual advance in the field of DNA recombination… great work by the labs of @brookscrickard1.bsky.social
and Michelle Wang

I would like to read what @marcofumasoni.bsky.social has to say about these data…!

Coincident with loss of Rev1, however… 🤔

Thanks so much, this is very interesting, so do you think (or can know) if they co-lost the fatty acid synthase and the DNA polymerase delta??? I now wonder if there might exist a functional association if this is the case…

Cool… can you provide me with the original work about fatty acid synthase dependency? We study the control that lipids exert onto genome (in)stability… thus not sure the two events you name are unrelated…!!! 🧐

Evidence that DNA polymerase δ contributes to initiating leading strand DNA replication in Saccharomyces cerevisiae - Nature Communications DNA polymerases δ and ε (Pols δ and ε) are thought to be responsible for lagging and leading strand synthesis, respectively. Here the authors present evidence that Pol δ contributes to the initiation ...

Hi, super nice story! Just to mention that in S. cerevisiae it has been shown that DNA synthesis can be replicated (at least for initiation) by DNA polymerase delta!, both basally and, most importantly with respect to your findings, in the absence of Pol ε! doi.org/10.1038/s414...

Huge congratulations, Milena! This is fantastic! You are going to make awesome things

Fat, stress, and survival: exploring the secret life of adipocytes Physical activity and exercise have beneficial effects on overall fitness and health. However, exercise-induced increases in metabolism require specific molecular adaptation of the muscle cells. This ...

Our PhD students @albamena.bsky.social & @annasjung.bsky.social wrote a thing on our ongoing efforts for understanding adipocytes & metabolism @erc.europa.eu
👇
www.europeandissemination.eu/article/fat-...

A redox switch in p21-CDK feedback during G2 phase controls the proliferation-cell cycle exit decision ROS oxidize cell cycle proteins and regulate cell proliferation. Vorhauser et al. show that oxidation of the cyclin-dependent kinase (CDK) inhibitor p21 at cysteine 41 (C41) during the G2 phase contro...

I am very happy to share that my PhD work in the Mansfeld lab (www.mansfeldlab.com) was published yesterday! 🎉 In this study, we characterized a novel redox switch on p21 that regulates proliferation: www.cell.com/molecular-ce...
Huge thanks to everyone involved for making this possible 🙏@icr.ac.uk

Tumor cell-adipocyte gap junctions activate lipolysis and contribute to breast tumorigenesis Nature Communications - Breast cancer cells interact with neighbouring adipocytes, but the mechanisms are not fully understood. Here, the authors show that triple-negative breast cancer (TNBC)...

New work from stellar scientists Jeremy Williams and Roman Camarda. Many contributors including the amazing Zena Werb and Atul Butte

Work explores how breast cancer cells interact directly with adipocytes via gap junctions, leading to lipid release.
@ctbatucsf.bsky.social @ucsfcancer.bsky.social

Ne manquez pas le 20e GERLI International Lipid Meeting, Strasbourg, 3-5 nov 2025

Rejoignez chercheurs et experts pour explorer les dernières avancées en biologie des lipides, assistez à des conférences, posters et prix scientifiques !

Plus d'info : : www.gerli.com/congres/welc...

Cartoon showing that G1 phase-synchronized cells showed dose-dependence in the relative mtDNAcn increase at 48 h after X-ray exposure, G2 cells at 24 h, and S phase cells at 24 and 48 h.

Ryosuke Seino, Kai Nishikubo and Hisanori Fukunaga interrogate cell cycle- and dose-dependent effects on mitochondrial DNA copy number variation following irradiation.
#OpenAccess #ReadandPublish
journals.biologists.com/jcs/article/...

Cell-type-specific nucleotide sharing through gap junctions impacts sensitivity to replication stress in Drosophila Cell proliferation, which underlies tissue growth and homeostasis, requires high levels of metabolites such as deoxynucleotides (dNTPs). The dNTP pool…

Boumard, B., Le Meur, G., Aboutine, L., Stefanutti, M., Maalouf, T., El-Hajj, M., Choi, B. J., Bauer, R., Bardin, A. J. (2025). Cell-type-specific nucleotide sharing through gap junctions impacts sensitivity to replication stress in #Drosophila. Dev Cell, www.sciencedirect.com/science/arti...

FEBS Press Using CRISPR-Cas9, we engineered a genetic system allowing the dose-dependent induction of a controllable number of DNA double-strand breaks in Saccharomyces cerevisiae. The tool was used to study th....

@morielab.bsky.social proudly presents a tool to induce, in S. cerevisiae, DNA double strand breaks in a site-specific AND in a dose-dependent manner, in a very simple way: just transform two plasmids!!! It allows you to assess many aspects of DNA damage signaling & repair!
doi.org/10.1111/febs...

Tardigrades tardigrades tardigrades

Reminiscent to how mitochondria can selectively extrude damaged mtDNA, locally, along with mitochondrial membranes (or through them) towards the cytoplasm… DNA-lipids interactions at play!!

🚀 Today we're launching the 'Night Science Institute', a non-for-profit organization to lead a cultural shift in science! You may say we're dreamers 😉, but we think we're not the only ones. Perhaps today you will join us to make the Day Science and Night Science parts of the process live as one!

Fatty Acid Synthase binds endogenous dsRNAs and dampens the innate immune response to exogenous dsRNAs by limiting their accumulation. In mammalian cells, the presence of double-stranded RNA (dsRNA) in the cytoplasm is a danger signal indicative of viral infection. Cells establish and maintain an antiviral state via the production of...

I am happy to share our last preprint, where we identified FASN as an endogenous dsRNA-associated factor and demonstrated that its depletion triggers endodsRNA accumulation and a stronger antiviral response to exogenous dsRNAs,#RNA, #interferon,#immunometabolism
www.biorxiv.org/cgi/content/...

New preprint from @morielab.bsky.social: tardigrades are super resistant to DNA insult, yet are not immortal. We asked: why & how do they die? We have discovered their Achilles’ heel! Check it to know (spoiler: it has to do of course with DNA… but also lipids!! 😍)

www.biorxiv.org/cgi/content/...

New preprint from @morielab.bsky.social: tardigrades are super resistant to DNA insult, yet are not immortal. We asked: why & how do they die? We have discovered their Achilles’ heel! Check it to know (spoiler: it has to do of course with DNA… but also lipids!! 😍)

www.biorxiv.org/cgi/content/...

Two scatter plots compare the time to first decision with reviews (in working days) for "Fast & Fair" and "Conventional" peer review methods. The left plot, titled "July-Dec 2024 peer reviewed only," and the right plot, titled "Jan-Jun 2025 peer reviewed only," both show that "Fast & Fair" has significantly lower decision times than "Conventional." Each plot has a Y-axis ranging from 0 to 100 working days and X-axis categories for the two review methods. Data points cluster lower for "Fast & Fair" and higher for "Conventional," with blue lines indicating lower mean times for "Fast & Fair." Asterisks (****) above both plots indicate statistical significance. A caption notes that the blue line represents the mean.

Phase II of our Fast & Fair peer review experiment is testing scalability. Results so far are promising. Read more at bit.ly/41N31tO.

#FastandFairPeerReview #PeerReview #ScientificPublishing

Felicidades!!!!!🎉

Excited for our next special issue and looking forward to working with Abby Buchwalter (@abbybuch.bsky.social) and Megan King (@luskinglab.bsky.social)! Working on the cell biology of the nucleus? Send your papers our way!
#notforprofit

Figure showing that scAb-AID2 with an anti-GFP nanobody adaptor enables degradation of GFP-fused proteins.

Moutushi Islam, Masato Kanemaki and colleagues describe their single-chain antibody-based auxin-inducible degron system which enables degradation of GFP-tagged and untagged proteins.
Highlight: journals.biologists.com/jcs/article/...
Article: journals.biologists.com/jcs/article/...

About our grants As a not-for-profit publisher, The Company of Biologists uses surplus income to benefit biology and the biological community. A key way in which we do this is through our grants, which support and encourage the sharing of knowledge throughout the community by facilitating international collaboration, event attendance and the organisation of scientific meetings, conferences and workshops. We offer the following grants: Scientific Meeting Grants Small Meeting Grants Grants from our Fund for Innovations in Sustainable Conferencing Travelling Fellowships DMM Conference Travel Grants JCS-FocalPlane Training Grants JEB Grants for junior faculty staff Development’s Pathway to Independence programme In addition, the British Society for Developmental Biology, British Society for Cell Biology and the Society for Experimental Biology offer travel grants as part of the funding we give them.

They are a REMARKABLE supporter of scientists and the community. In addition to their five journals, they support dozens of scientific meetings each year, and provide travel grants and other support 2/n
www.biologists.com/grants/

A sterol‐PI(4)P exchanger modulates the Tel1/ATM axis of the DNA damage response | The EMBO Journal image image How can metabolic and environmental cues modulate the DNA damage response (DDR)? Here, the master DDR kinase Tel1/ATM is found to bind phosphatidylinositol‐4‐phosphate (PI(4)P) at the Golgi, altering its availability in the ...

We exploited the system to discover that Tel1, ATM in humans, congregates at the nuclear envelope during the early steps of DNA break sensing… combined with our previous finding that Tel1/ATM bind lipids (doi.org/10.15252/emb...), this
hints at nuclear envelope lipids as key in DNA damage detection!