@MorieLAB

FEBS Press Using CRISPR-Cas9, we engineered a genetic system allowing the dose-dependent induction of a controllable number of DNA double-strand breaks in Saccharomyces cerevisiae. The tool was used to study th....

@morielab.bsky.social proudly presents a tool to induce, in S. cerevisiae, DNA double strand breaks in a site-specific AND in a dose-dependent manner, in a very simple way: just transform two plasmids!!! It allows you to assess many aspects of DNA damage signaling & repair!
doi.org/10.1111/febs...

Tardigrades tardigrades tardigrades

Reminiscent to how mitochondria can selectively extrude damaged mtDNA, locally, along with mitochondrial membranes (or through them) towards the cytoplasm… DNA-lipids interactions at play!!

🚀 Today we're launching the 'Night Science Institute', a non-for-profit organization to lead a cultural shift in science! You may say we're dreamers 😉, but we think we're not the only ones. Perhaps today you will join us to make the Day Science and Night Science parts of the process live as one!

Fatty Acid Synthase binds endogenous dsRNAs and dampens the innate immune response to exogenous dsRNAs by limiting their accumulation. In mammalian cells, the presence of double-stranded RNA (dsRNA) in the cytoplasm is a danger signal indicative of viral infection. Cells establish and maintain an antiviral state via the production of...

I am happy to share our last preprint, where we identified FASN as an endogenous dsRNA-associated factor and demonstrated that its depletion triggers endodsRNA accumulation and a stronger antiviral response to exogenous dsRNAs,#RNA, #interferon,#immunometabolism
www.biorxiv.org/cgi/content/...

New preprint from @morielab.bsky.social: tardigrades are super resistant to DNA insult, yet are not immortal. We asked: why & how do they die? We have discovered their Achilles’ heel! Check it to know (spoiler: it has to do of course with DNA… but also lipids!! 😍)

www.biorxiv.org/cgi/content/...

New preprint from @morielab.bsky.social: tardigrades are super resistant to DNA insult, yet are not immortal. We asked: why & how do they die? We have discovered their Achilles’ heel! Check it to know (spoiler: it has to do of course with DNA… but also lipids!! 😍)

www.biorxiv.org/cgi/content/...

Two scatter plots compare the time to first decision with reviews (in working days) for "Fast & Fair" and "Conventional" peer review methods. The left plot, titled "July-Dec 2024 peer reviewed only," and the right plot, titled "Jan-Jun 2025 peer reviewed only," both show that "Fast & Fair" has significantly lower decision times than "Conventional." Each plot has a Y-axis ranging from 0 to 100 working days and X-axis categories for the two review methods. Data points cluster lower for "Fast & Fair" and higher for "Conventional," with blue lines indicating lower mean times for "Fast & Fair." Asterisks (****) above both plots indicate statistical significance. A caption notes that the blue line represents the mean.

Phase II of our Fast & Fair peer review experiment is testing scalability. Results so far are promising. Read more at bit.ly/41N31tO.

#FastandFairPeerReview #PeerReview #ScientificPublishing

Felicidades!!!!!🎉

Excited for our next special issue and looking forward to working with Abby Buchwalter (@abbybuch.bsky.social) and Megan King (@luskinglab.bsky.social)! Working on the cell biology of the nucleus? Send your papers our way!
#notforprofit

Figure showing that scAb-AID2 with an anti-GFP nanobody adaptor enables degradation of GFP-fused proteins.

Moutushi Islam, Masato Kanemaki and colleagues describe their single-chain antibody-based auxin-inducible degron system which enables degradation of GFP-tagged and untagged proteins.
Highlight: journals.biologists.com/jcs/article/...
Article: journals.biologists.com/jcs/article/...

About our grants As a not-for-profit publisher, The Company of Biologists uses surplus income to benefit biology and the biological community. A key way in which we do this is through our grants, which support and encourage the sharing of knowledge throughout the community by facilitating international collaboration, event attendance and the organisation of scientific meetings, conferences and workshops. We offer the following grants: Scientific Meeting Grants Small Meeting Grants Grants from our Fund for Innovations in Sustainable Conferencing Travelling Fellowships DMM Conference Travel Grants JCS-FocalPlane Training Grants JEB Grants for junior faculty staff Development’s Pathway to Independence programme In addition, the British Society for Developmental Biology, British Society for Cell Biology and the Society for Experimental Biology offer travel grants as part of the funding we give them.

They are a REMARKABLE supporter of scientists and the community. In addition to their five journals, they support dozens of scientific meetings each year, and provide travel grants and other support 2/n
www.biologists.com/grants/

A sterol‐PI(4)P exchanger modulates the Tel1/ATM axis of the DNA damage response | The EMBO Journal image image How can metabolic and environmental cues modulate the DNA damage response (DDR)? Here, the master DDR kinase Tel1/ATM is found to bind phosphatidylinositol‐4‐phosphate (PI(4)P) at the Golgi, altering its availability in the ...

We exploited the system to discover that Tel1, ATM in humans, congregates at the nuclear envelope during the early steps of DNA break sensing… combined with our previous finding that Tel1/ATM bind lipids (doi.org/10.15252/emb...), this
hints at nuclear envelope lipids as key in DNA damage detection!

FEBS Press Using CRISPR-Cas9, we engineered a genetic system allowing the dose-dependent induction of a controllable number of DNA double-strand breaks in Saccharomyces cerevisiae. The tool was used to study th....

@morielab.bsky.social proudly presents a tool to induce, in S. cerevisiae, DNA double strand breaks in a site-specific AND in a dose-dependent manner, in a very simple way: just transform two plasmids!!! It allows you to assess many aspects of DNA damage signaling & repair!
doi.org/10.1111/febs...

Membranes are functionalized by a proteolipid code - BMC Biology Membranes are protein and lipid structures that surround cells and other biological compartments. We present a conceptual model wherein all membranes are organized into structural and functional zones...

Honoured to have inspired the theme: doi.org/10.1186/s129...

Have a nice #FluorescenceFriday! This is the tip of a fig wasp antenna with auto-fluorescence in blue and DNA in red! These insects are very very tiny

Spots are filling up!!!! Join us at our workshop at @cabimer.bsky.social !!!

Excited to share the first paper of my PhD with @marcofumasoni.bsky.social ‬, now published in @molsystbiol.org 🥳! We explored how nutrient levels influence adaptation to perturbed DNA replication. Here’s what we learned 🧵👇 www.embopress.org/doi/full/10....

We are very, very lucky at CRBM to get this awesome visitor!!! Ask for a QRCode if you want to join on-site!!

#art #science #biology
@morielab.bsky.social

Focus on numbers – characterizing protein accumulation at DNA double-strand breaks Summary: Spatial intensity distribution analysis allows quantitative description of protein accumulation in DNA repair foci based on confocal images.

I’m very happy to see part of my postdoctoral work published!
In this study, we developed a pipeline to measure absolute protein numbers at DNA double-strand break sites from confocal images.
@jcellsci.bsky.social

journals.biologists.com/jcs/article-...

🎓 31e Colloque des Thésards du CRBM 🎉
Bravo à Dimitra, Jana, Janélie, Luisa, Rekia, Sotiria et Symeon pour l’orga au top !
Talks passionnants, lieu sublime, soirée mémorable.
Merci à toutes et tous pour ce bel événement 👏 #CRBM #Science

Come to join us at this fantastic workshop at @cabimer.bsky.social on October 17th.

If you have a nice idea, go for it! One of the best experiences in a career!!! ❤️

#La_vie_est_belle est aux jardins suspendus du Havre!! MRI est présent au festival Photo Nature!! Tout est monté, tout est prêt pour le 23 mai!!

@addictosciences.bsky.social‬

The abstract submission deadline for the 2nd edition of our #EMBOLipidDroplets Workshop (21-26 September 2025) is approaching.

Check out the agenda with an amazing lineup of speakers and submit your abstract before 10 June 2025!

@embo.org
@biologists.bsky.social

meetings.embo.org/event/25-lip...

⚠️ Discovery of a new mode of viral transmission:

Deltaviruses spread through a viral Trojan Horse !

These viral satellites that do not encode their own glycoproteins, are in fact physically encapsulated within their helper virus particles!

www.biorxiv.org/content/10.1...

A thread 1/14

Awesome, Joe!!! Super convincingly inside. But then, the deltavirus particles seen in “inset 2”, which are “free”, are they unproductive?

The nucleoid of rapidly growing Escherichia coli localizes close to the inner membrane and is organized by transcription, translation, and cell geometry - Nature Communications The mechanisms underlying bacterial chromosome configuration are not fully understood. Here, Spahn et al. show that the Escherichia coli nucleoid adopts a condensed, membrane-proximal configuration du...

"E. coli nucleoid adopts a condensed, membrane-proximal configuration during rapid growth, an active role of transertion (coupled transcription, translation, and membrane insertion) in nucleoid organization" #microsky www.nature.com/articles/s41...

It is the left one, but it is not seen because it is too perfect, but because the nuclear envelope is triple or even, more surrounded by multiple membranes!!