BF Francis Ouellette's Avatar

BF Francis Ouellette

@bffo.bsky.social

Bioinformatics 🧬πŸ–₯️πŸ§ͺ #PLOS Comp Biol Education Sect. Editor; #DATABASE OUP Associate Editor; #OpenScience #OpenAccess #OpenData; friend of @jxtxfoundation.bsky.social, @abinstitute.bsky.social - I am πŸ‡¨πŸ‡¦

2,939 Followers  |  4,630 Following  |  304 Posts  |  Joined: 01.02.2024  |  2.2091

Latest posts by bffo.bsky.social on Bluesky

Thank you OBF (and especially Taz) for this lovely post about the GigaScience team. I've been going to your #BOSC meetings since 2011 and will miss catching up with you all each summer, but hopefully it's not goodbye!

01.10.2025 08:48 β€” πŸ‘ 7    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
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Navigating open-source waters: the pharmaceutical industry’s role in bioontology development Abstract. Bioontologies are core to many data management strategies, artificial intelligence and machine learning initiatives, and search functionality wit

From #OUP 's #DATABASE journal | Navigating #OpenSource waters: the pharmaceutical #industry's role in #bioontology development | #Bioinformatics #Genomics #Ontology #OpenScience 🧬 πŸ–₯️ πŸ§ͺ πŸ”“ πŸ‡©πŸ‡°
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academic.oup.com/database/art...

01.10.2025 18:26 β€” πŸ‘ 4    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0

Thank you @openbio.bsky.social for summarizing a great (but too short) #OpenScience #OpenAccess story … All of us lost a great team of friends and colleagues in this sad story.

01.10.2025 12:40 β€” πŸ‘ 4    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
Scott Edmunds cuts the cake at the 2025 GigaScience birthday party at ISMB/ECCB 2025

Scott Edmunds cuts the cake at the 2025 GigaScience birthday party at ISMB/ECCB 2025

An open letter about the recent cuts at GigaScience: www.open-bio.org/2025/09/30/2...
(open for signatures until the end of October)

#OpenScience #OpenData #GigaScience

30.09.2025 21:02 β€” πŸ‘ 8    πŸ” 12    πŸ’¬ 1    πŸ“Œ 3

These are all valuable suggestions for handling the (sudden) end of a project.

Keep in mind that code which is not actively being used and maintained is dead and will quickly become useless.

Also few projects will be adopted by an active open source community.

29.09.2025 20:43 β€” πŸ‘ 3    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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Ten simple rules for writing a PLOS Computational Biology quick tips article

If this had been in PLOS CB, it would have been a Ten Simple Rules (TSR) paper, not a Quick Tips (QT) paper. As we write in our TSR about writing a QT paper (in Rule 1): "Ten Simple Rules are more to develop soft skills, career promotion/advancement ..." πŸ§ͺπŸ”“
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journals.plos.org/ploscompbiol...

29.09.2025 20:23 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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10 quick tips for making your software outlive your job Loss of key personnel has always been a risk for research software projects. Key members of the team may have to step away due to illness or burnout, to care for a family member, from a loss of financ...

From @richlitt.bsky.social and colleagues in @arxiv-cs-cl.bsky.social | 10 quick tips for making your software outlive your job | πŸ§ͺ πŸ”“ #ProfessionalDevelopment #Education #OpenSource #OpenScience
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arxiv.org/abs/2505.06484

29.09.2025 20:16 β€” πŸ‘ 6    πŸ” 1    πŸ’¬ 1    πŸ“Œ 1
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πŸ“’ NEW GENOME ALERT

In #G3journal, Frandsen et al. present a chromosome-scale assembly of the tetraploid epazote, a perennial plant growing in tropical climates in the Americas with regional culinary and medicinal importance. buff.ly/Vbp0rde

26.09.2025 20:01 β€” πŸ‘ 4    πŸ” 4    πŸ’¬ 0    πŸ“Œ 0
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🧰 Now published in Bioinformatics Advances: "Atlantool: A command line tool to retrieve DNA and RNA sequencing reads from BAM files by the read identifier"   

Read the full paper here: https://doi.org/10.1093/bioadv/vbaf226Β 

Authors include: @nibor.org, @egiannoulatou.bsky.social

26.09.2025 09:02 β€” πŸ‘ 4    πŸ” 2    πŸ’¬ 1    πŸ“Œ 1
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A review on Gene Ontology evaluations Abstract. The analysis of the large and heterogeneous datasets that characterize modern biology demands systems capable of representing biological knowledg

From @borja-pitarch.bsky.social and colleagues in #OUP 's #DATABASE journal | A review on #GeneOntology evaluations | #Bioinformatics #Genomics #Review #OpenScience #GO 🧬 πŸ–₯️ πŸ§ͺ πŸ”“πŸ‡ͺπŸ‡Έ
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academic.oup.com/database/art...

26.09.2025 13:07 β€” πŸ‘ 9    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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Galaxy single-cell & spatial omics community update: Navigating new frontiers in 2025 The Galaxy single-cell and spatial omics community (SPOC) brings together over 175 tools, 120+ training resources, and a global user community in a unified FAIR platform. By integrating leading suites...

From @cellpress.bsky.social #Genomics | Galaxy #single-cell & spatial omics community update: Navigating new frontiers in 2025 | #Bioinformatics #Genomics #OpenScience #OpenSource #Perspective #UseGalaxy 🧬 πŸ–₯️ πŸ§ͺ πŸ”“
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www.cell.com/cell-genomic...

26.09.2025 12:56 β€” πŸ‘ 8    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
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Raising the standard: GigaScience Press on metadata and discoverability - Crossref To mark Crossref’s 25th anniversary, we launched our first Metadata Awards to highlight members with the best metadata practices. GigaScience Press, based in Hong Kong, was the leader among small publ...

Only just noticed @crossref.bsky.social posted their interview with me talking about winning one of the inaugural Crossref Metadata awards was finally published on my last day of work. It's always good to end on a high!

www.crossref.org/blog/raising...

24.09.2025 08:49 β€” πŸ‘ 6    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
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Newly expanded version of my guide to scientific writing -- known as the β€œ15 steps” -- published in PLOS Computational Biology. Special thanks to Γ‰ric Marty for creating a fantastic visualization.

Check it out: journals.plos.org/ploscompbiol...

#ScientificWriting #PLOSComputationalBiology

24.09.2025 17:54 β€” πŸ‘ 36    πŸ” 21    πŸ’¬ 1    πŸ“Œ 2
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How to write a scientific paper in fifteen steps

From @jdrakephd.bsky.social & @bahanbug.bsky.social in @plos.org #Computational #Biology | How to write a scientific paper in fifteen steps | #Education #Science πŸ§ͺ πŸ”“Β #GoodReadingForAll CC/ @ppalagi.bsky.social
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journals.plos.org/ploscompbiol...

25.09.2025 12:29 β€” πŸ‘ 9    πŸ” 6    πŸ’¬ 0    πŸ“Œ 0
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Wikipedia Is Vital: Channeling Energy Into Micro-Edits Is a Win-Win-Win - Absolutely Maybe Wikipedia is, β€œwithout exaggeration, the digital world’s factual foundation,” wrote Josh Dzieza recently. It’s a target because of that, squarely in the…

Want to be able to start micro-editing on Wikipedia in a few minutes – and know why you could be very glad you did? Then my new post @plos.org is just what you need!

absolutelymaybe.plos.org/2025/09/21/w...

#Wikipedia

21.09.2025 07:43 β€” πŸ‘ 61    πŸ” 35    πŸ’¬ 1    πŸ“Œ 2

Important for #autistic people and other marginalized groups who are being targeted using health systems databases (particularly those on medicaid and medicare in the U.S.).

There is an ethical responsibility to stop targeting and de-identifying data is one of the best ways to help all of us.

24.09.2025 17:28 β€” πŸ‘ 4    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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Ten quick tips for protecting health data using de-identification and perturbation of structured datasets Author summary Healthcare systems and health research programmes collect large amounts of patient data that are often shared both within organisations and across institutional boundaries. Health data ...

From @plos.org #Computational #Biology | Ten quick tips for protecting health data using de-identification and perturbation of structured datasets | #Bioinformatics #Education #PLOSCBQT #OpenScience #DataScience 🧬 πŸ–₯️ πŸ§ͺ πŸ”“ πŸ‡ΏπŸ‡¦ CC/ @ppalagi.bsky.social
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journals.plos.org/ploscompbiol...

24.09.2025 16:54 β€” πŸ‘ 7    πŸ” 2    πŸ’¬ 0    πŸ“Œ 1
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Ten simple rules for building and maintaining sustainable high-performance computing infrastructure for research in resource-limited settings

From @plos.org #Computational #Biology | Ten simple rules for building and maintaining sustainable high-performance computing infrastructure for research in resource-limited settings | #Africa #HPC #PLOSCBTSR πŸ–₯️ πŸ§ͺ πŸ”“
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journals.plos.org/ploscompbiol...

23.09.2025 12:19 β€” πŸ‘ 4    πŸ” 4    πŸ’¬ 0    πŸ“Œ 0

9 more days … #Africa #Bioinformatics #Health #Informatics #Education

21.09.2025 21:28 β€” πŸ‘ 2    πŸ” 3    πŸ’¬ 0    πŸ“Œ 0
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β€œFrom Data to Discovery: Opportunities with the African Bioinformatics Institute” delivered at the recent Data for Health in Africa Meeting & 5th DS-I Africa Consortium Meeting in Accra, Ghana. Explore ABI’s vision as well current and future activities: www.linkedin.com/pulse/showca...

11.09.2025 06:21 β€” πŸ‘ 2    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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Cancer histone mutations impactΒ protein binding and DNA repair with possible links to genomic instability Abstract. Histones are key epigenetic factors that regulate the accessibility and compaction of eukaryotic genomes, affecting DNA replication and repair, a

How do histone mutations contribute to cancer development?
Our new study reveals that these mutations impact critical sites where histones interact with DNA or proteins, in some cases disrupting genome maintenance.
academic.oup.com/nar/article/...

18.09.2025 14:49 β€” πŸ‘ 2    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
Validate User

From #NAR journal | #Cancer #histone mutations impact protein binding and DNA repair with possible links to genomic instability | From my friend @davidlandsman.bsky.social & former colleague @panchenko-lab.bsky.social | #Bioinformatics #Genomics 🧬 πŸ–₯️ πŸ§ͺ πŸ”“ πŸ‡¨πŸ‡¦
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academic.oup.com/nar/article/...

19.09.2025 22:24 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

Not sure if this (these?) positions are filled yet, but as an ex-MSL tenured PI, and a fan of Micro, I can only highly recommend this position and department… Great city, great University, great campus, greatest students and great colleagues! Go for it!

12.09.2025 02:59 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Microbiology and Immunology and the Michael Smith Labs are seeking candidates for an Assistant Professor of Teaching in STEM Public Engagement position.

Learn more and apply at: www.msl.ubc.ca/careers/

#IndigenousinSTEM #BlackInNature #WomenInSTEM #MinoritiesInSTEM #DiversityInSTEM #STEMEducation

22.07.2025 16:00 β€” πŸ‘ 17    πŸ” 24    πŸ’¬ 2    πŸ“Œ 2

Ezra Klein thinks that β€œblack people are stupid” and β€œgay people should be stoned to death” is practicing politics the β€œright way”

Can we stop pretending he is some political sage?

11.09.2025 11:30 β€” πŸ‘ 557    πŸ” 31    πŸ’¬ 1    πŸ“Œ 0
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My review of computational methods for anthropological genetics with @kwittadna.bsky.social is out for the Yearbook issue of AJBA.

We talk about all sorts of cool methods that YOU could use too!

Also check out this great figure we commissioned from @janey1216.bsky.social

doi.org/10.1002/ajpa...

20.03.2025 21:08 β€” πŸ‘ 14    πŸ” 12    πŸ’¬ 0    πŸ“Œ 1
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Stephen Jay Gould was born OTD in 1941.

β€œOrganisms are not billiard balls, propelled by simple and measurable external forces to predictable new positions on life's pool table.... Organisms have a history that constrains their future in myriad, subtle ways.”

πŸ¦«πŸ¦‹πŸ‹πŸŒ±πŸ§ πŸ—ƒοΈπŸ§ͺ#HistSTM #PhilSci #EvoBio

10.09.2025 16:41 β€” πŸ‘ 158    πŸ” 44    πŸ’¬ 8    πŸ“Œ 8
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Bioconductor: Planning a third decade of comprehensive support for genomic data science This opinion piece discusses the Bioconductor project for open-source bioinformatics and the engineering concepts underlying its effectiveness to date. Since the inception of Bioconductor in 2002 with...

From @cp-patterns.bsky.social | #Bioconductor: Planning a third decade of comprehensive support for genomic data science | #Bioinformatics #Genomics #OpenScience #OpenSource 🧬 πŸ–₯️ πŸ§ͺ πŸ”“
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www.cell.com/patterns/ful...

11.09.2025 12:57 β€” πŸ‘ 15    πŸ” 6    πŸ’¬ 0    πŸ“Œ 0

This is what this other PLOS CB paper is about! What @stefaniebutland.bsky.social said!

bsky.app/profile/bffo...

11.09.2025 12:15 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Catalyzing computational biology research at an academic institute through an interest network Author summary Scientists have widely adopted computing in their research, and the relative importance of computational methods in biology continues to increase. However, a persistent gap exists betwe...

From @plos.org #Computational #Biology | Catalyzing computational biology research at an academic institute through an interest network | #Bioinformatics #Education #OpenScience 🧬 πŸ–₯️ πŸ§ͺ πŸ”“
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journals.plos.org/ploscompbiol...

11.09.2025 12:12 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 0    πŸ“Œ 1

@bffo is following 20 prominent accounts