Eduard Unterauer

Left-handed DNA with conventional right-handed as probes boosts multiplex labelling
📷 @eduardunterauer.bsky.social @evaschentarra.bsky.social Isabelle Pachmayr & @taishatashrin.bsky.social et al
@lmumuenchen.bsky.social @mpibiochem.bsky.social in @natcomms.nature.com
➡️ bpod.org.uk/archive/2025...

Thrilled to announce some big news!

Excited to share that I’ve been awarded a Wellcome Trust Early Career Award to establish my research as a Group Leader in the Glycosciences Program at the Institute of Biology and Experimental Medicine (IBYME) in Buenos Aires, Argentina, beginning in early 2026.

Mirror, mirror on the wall... 🪞 I'm super proud to have contributed to our latest work on left-handed DNA-PAINT! Here we introduce 6 new sequences using the left-handed enantiomers of our speed-optimized DNA-PAINT palette, enabling out-of-the-box 12-plex imaging without extra hybridization steps. 🌈🔬

Grateful to be part of this work 😊. We are bringing single protein resolved super-resolution microscopy closer to the investigation of systems biological questions 🎨🪄🌈. Congratulations to all authors 🥳

Next on stage is Eduard Unterauer @eduardunterauer.bsky.social from @jungmannlab.bsky.social reporting spatial proteomics with DNA PAINT #SMLMS2025

Resolving the structural basis of therapeutic antibody function in cancer immunotherapy with RESI - Nature Communications The nanoscale organization of the antigen-antibody complexes influences the therapeutic action of monoclonal antibodies. Here, the authors present a multi-target 3D RESI imaging assay for the nanomete...

Congratulations to everyone involved: @ipachmayr.bsky.social, @lumasullo.bsky.social, @susannereinhardt.bsky.social, Jisoo Kwon, Ondřej Skořepa, Maite Llop, Sylvia Herter, Marina Bacac and Christian Klein. (6/6)
Read the full story here: www.nature.com/articles/s41...

Spatial and stoichiometric in situ analysis of biomolecular oligomerization at single-protein resolution - Nature Communications Extracting quantitative information on biomolecular oligomerisation with high resolution remains a significant challenge. Here, the authors propose SPINNA, a framework that compares nearest-neighbour ...

Spatial and stoichiometric in situ analysis of biomolecular oligomerization at single-protein resolution

We are excited to present our latest work published in @natcomms.nature.com

www.nature.com/articles/s41...

Very excited to present our latest work: SPINNA, an analysis framework and software package for single-protein resolution data! 🖥️🤩

We can directly quantify stoichiometry and oligomerization from super-res (DNA-PAINT, RESI) images!! 🧬🎨

Nanobinders for Synaptotagmin 1 enable the analysis of synaptic vesicle dynamics in rodent and human models. Synaptic neurotransmission is a critical hallmark of brain activity and one of the first processes to be affected in neural diseases. Monitoring this process, and in particular synaptic vesicle recycl...

Excited for our latest work! We developed nanobinders for the luminal domain of Synaptotagmin 1 (calcium sensor for synaptic vesicles). Thanks among others to @verstrekenlab.bsky.social @opazo.bsky.social @meunierlab.bsky.social @volkerhaucke-lab.bsky.social www.biorxiv.org/content/10.1...

IMAGING LIGAND-RECEPTOR INTERACTIONS AT SINGLE-PROTEIN RESOLUTION WITH DNA-PAINT🔬
Ever wonder how cells "talk"? It starts when ligands bind to receptors on cell surfaces. We have cracked the challenge of imaging small ligands on cell surfaces. #DNAPAINT #celltalk 💬
doi.org/10.1002/smtd...

Cell Press: STAR Protocols STAR Protocols is an open access, peer-reviewed journal from Cell Press. We offer structured, transparent, accessible, and repeatable step-by-step experimental and computational protocols from all are...

One month ago today, I published my first paper with the @jungmannlab.bsky.social 🥳
What better way to celebrate #MicroscopyMonday than with this STAR Protocol on SUM-PAINT spatial proteomic imaging: a guide for highly multiplexed DNA-PAINT imaging in neurons. star-protocols.cell.com/protocols/4066

ÅNGSTRÖM-RESOLUTION IMAGING OF CELL-SURFACE GLYCANS 🧬🎨🍬

The glycocalyx, our cells' sugar coat, holds secrets in immunology, cancer, viral infections, and more. Visualizing its molecular architecture was impossible… until now. #glycotime #microscopy

www.biorxiv.org/content/10.1...

At the end of the PhD journey, you realize the goal was actually only part of the deal. It’s the people you get to know along the way and the experiences you share that shape you to become a wiser and happier human being. Thanks for the great time @JungmannLab

Very proud to be part of this exciting work 😊. It's a great step forward in enabling highest resolution DNA-PAINT for everyone 🌈

x.com/PhilippSteen/s…

Ready to present the SUM-PAINT story at the single molecule approaches to biology @GordonConf in beautiful Maine 😊. If you are interested, stop by Wednesday or Thursday 🙂

How many synapses can you detect in a single Field of View? The answer is many😊. Here we have a 7plex image with 450 Synapses imaged with SUM-PAINT @Jungmannlab, that I am excited to share with you. Happy #FluorescenceFriday

We wish you a happy #MicroscopyMonday and if you got interested into applying this technology yourself, get in touch with @Jungmannlab 😊

If you got curious check out the full publication 😊 @JungmannLab @CellCellPress

doi.org/10.1016/j.cell…

Very proud to finally see our huge collaborative work published 😊. Once again, congrats to all authors and thanks for sticking with me through all these times 🙈🚀

x.com/JungmannLab/st…