Harry Low’s Lab

crYOLO did us proud on our Vipp1 filaments.. none of the other programs worked as well. We had a mental toast to you at the time. Thanks for speaking out about this tough card you’ve been dealt. I’ll be thinking of you

Mapping the ultrastructural topology of septin cage entrapment

PhD studentship with @carolynmoores1.bsky.social

Direct link here: www.lshtm.ac.uk/study/fees-a...

Come work with Ben Berks FRS in Oxford
2 x PDRA posts: Molecular Analysis of Bacterial Outer Membrane Protein Biogenesis

2 complementary projects investigating bacterial outer membrane protein biogenesis. Building on our recent work (Nature (2015) 647: 479-487)

my.corehr.com/pls/uoxrecru...

Job opening for Research Group Leader in Structural Studies at MRC Laboratory of Molecular Biology, focusing on macromolecular structures.

Are you a structural biologist pushing the boundaries of molecular science with an ambitious research programme?
Join our Structural Studies Division as a tenure-track Group Leader, with core funding, world-leading facilities & enthusiastic colleagues.
Apply by 16 MAR
www.nature.com/naturecareer...

Our latest preprint: Together with the team of Jan Löwe, @danieltamarit.bsky.social and many others we discovered and characterized several Asgard tubulin genes and propose that microtubule architecture and dynamics evolved in Asgard archaea prior to eukaryogenesis
www.biorxiv.org/content/10.6...

Knockout pretty! Definitely worth the wait! 😉

A small polymerase ribozyme that can synthesize itself and its complementary strand The emergence of a chemical system capable of self-replication and evolution is a critical event in the origin of life. RNA polymerase ribozymes can replicate RNA, but their large size and structural ...

How could a simple self-replicating system emerge at the origins of life? RNA polymerase ribozymes can replicate RNA, but existing ones are so large that their self-replication seems impossible. Could they be smaller?

Excited to share our latest work in @science.org on a new small polymerase.
1/n

❗️Highly recommended - please consider applying, 3 weeks to go👇🏻

Extremophile alert!

Registration is OPEN for the 2026 EMBO Archaeal workshop in Cambridge.

Spaces are limited, so register soon with an abstract if you’d like to give a talk.

If you can’t come in person, we are welcoming virtual attendees. So join us online where all talks will be screened!

We are looking for a new RA to join our team working on host-pathogen interactions during Salmonella infection. The appointment is for two years and you will join a diverse team, using cell and protein biochemistry to further our understanding of pathogenesis. my.corehr.com/pls/uoxrecru...

Join our division of Structural Studies at @mrclmb.bsky.social in the wonderful group of @suyangzhang.bsky.social!

Exploiting the bacterial DNA damage response as an alternative antimicrobial at Newcastle University on FindAPhD.com PhD Project - Exploiting the bacterial DNA damage response as an alternative antimicrobial at Newcastle University, listed on FindAPhD.com

E. coli is the leading bacterium causing death from AMR infections worldwide. If you'd like to explore approaches to exploit the DNA damage response as alternative antimicrobial, please apply to the following PhD studentship available in my lab starting October 2026: www.findaphd.com/phds/project...

Maybe that’s your next mission..

Alessandro Costa @costalaboratory.bsky.social, Dana Branzei and myself are co-organising the 2026 Machines on Genes meeting in beautiful Crete as the 94th Harden Conference hosted by @biochemsoc.bsky.social

Register now - lots of opportunities for selected talks www.eventsforce.net/biochemsoc/f...

Why solutions to antimicrobial resistance are urgently needed Summary: This Editorial discusses the growing global problem of antimicrobial resistance, and new and emerging opportunities for developing real-world solutions, involving both basic science and clini...

‘Why solutions to antimicrobial resistance are urgently needed‘ sergemostowylab.bsky.social & I had the opportunity to write an editorial for @dmmjournal.bsky.social ‘s collection celebrating 100 years of @biologists.bsky.social you can read it here: journals.biologists.com/dmm/article/...

🔬 Just out in @NatureComms!
Using cryo-CLEM and cryo-ET, we reveal the unique ultrastructure of dopaminergic varicosities in the striatum.
Amazing collaboration with @davip-bdx.bsky.social and Etienne Herzog @iins-bordeaux.bsky.social
Congratulations to Paul and Robin for this fantastic work! 🎉

IsoNet2 determines cellular structures at submolecular resolution without averaging https://www.biorxiv.org/content/10.64898/2025.12.09.693325v1

My excellent collaborator, Giulia Zanetti, is advertising for a post-doc to work on our shared MRC grant. Please consider applying to this great lab with a supportive mentor to do some exciting structural biology.
www.ucl.ac.uk/work-at-ucl/...

Polymyxins slow down lateral diffusion of proteins and lipopolysaccharide in the E. coli outer membrane - Communications Biology Multi-scale molecular dynamics simulations reveal that polymyxins form polymyxin-protein aggregates upon associating with the E. coli outer membrane thereby reducing lateral mobility of outer membrane...

Our paper on polymyxin interacting with the E. coli outer membrane is out! Simulations by the very talented @dheerajprakaash.bsky.social www.nature.com/articles/s42...

To scale outer membrane protein island simulated at coarse-grained resolution with portions refined at all atom resolution.

Please RT. Post-doc opportunity alert! 💥 closing soon 10th December.. Come join our team (www.thelowlab.org) at Imperial, London, working on the structure and mechanism of bacterial secretion systems.

For more details and to apply please see

www.imperial.ac.uk/jobs/search-...

Description Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...

We're advertising for a bacteriology technician and a post-doc to work on AI-guided antibiotic development as part of a large multidisciplinary Fleming Initiative project:
www.imperial.ac.uk/jobs/search-...

www.imperial.ac.uk/jobs/search-...

A ubiquitin-like protein controls assembly of a bacterial type VIIb secretion system Cryo-EM structure reveals how a ubiquitin-like protein orchestrates assembly of a bacterial weapon system.

Our latest T7SS study is now out in Science Advances!
We solved the cryoEM structure of the T7SSb core unit (T7bCU) composed of YukB, YukC, and YukD from Bacillus subtilis, revealing how these components assemble within the secretion machinery.

www.science.org/doi/10.1126/...

Postdoctoral Researcher (Dr Miguel Montez) | John Innes Centre An exciting opportunity has arisen for a Postdoctoral Researcher to join the Wellcome Trust project led by Dr Miguel Montez and hosted within the Dodd Group at the John Innes Centre.

📣 Looking for a 3-Year Postdoc @johninnescentre.bsky.social to join my Wellcome project.

This is a highly interdisciplinary project that explores chromatin dynamics in 🌱 plant responses across timescales, from circadian rhythms to seasonal changes

📅 Closes on 10 Dec.
www.jic.ac.uk/vacancies/36...

34 fully-funded PhD studentships in the Biosciences across UK Universities in the South West (including Bristol Biochemistry!)

Home and International students eligible

Information and applications here
www.swbio.ac.uk

Assembly, architecture and functional roles of microbial surface layers - Nature Reviews Microbiology Surface layers (S-layers) are ubiquitous protein assemblies that coat prokaryotic cells, with their functional roles increasingly coming into focus. In this Review, Isbilir and colleagues discuss rece...

Assembly, architecture and functional roles of microbial surface layers www.nature.com/articles/s41... #jcampubs

An Asgard archaeon with internal membrane compartments

Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!

www.biorxiv.org/content/10.1...

I mean, wow! 👏

First in-situ glimpse of the Tad pilus system in all its glory! 👏

Excellent #postdoc opportunity available in @sjorsscheres.bsky.social’ group, working on new image processing algorithms for #cryoEM structure determination in their #RELION open-source software.
www.nature.com/naturecareer...
Apply by 25 NOV
#PostdocJobs #ScienceJobs

Please RT. Post-doc opportunity alert! 💥 closing 10th December.. Come join our team (www.thelowlab.org) at Imperial, London, working on the structure and mechanism of bacterial secretion systems.

For more details and to apply please see

www.imperial.ac.uk/jobs/search-...