Shane Gonen

Assistant Professor in Structural Biology and Biochemistry, Department of Molecular Biology & Biochemistry University of California, Irvine is hiring. Apply now!

Our home department of Molecular Biology & Biochemistry at UC Irvine is looking to hire a new tenure-track assistant professor in the broad area of structural biology. Come be our colleague! recruit.ap.uci.edu/JPF09887

Please apply and/or share this post.

Herculean effort by the Wiles lab @UCIBioSci Congrats to the entire team and the first author postdoc Liz for this amazing cover art! Proud of #Nicholaslab members Naveena and Julio for the small role we played in this groundbreaking work

We’re thrilled to be featured on the May cover of Nature Microbiology... And our Research Briefing is out now—check it out, it’s 🔥! www.nature.com/articles/s41...

"Phollow" the link to our May issue to read about...

💥lysing bacterial pathogens
⛽microbial alkane oxidation
🌱importance of seed-borne bacteria
🙅‍♀️protective antibodies for norovirus
🚰E. coli in urban drinking water

...and more!👇
www.nature.com/nmicrobiol/v...

Beautiful new work from our colleagues down the hall 🔬🥂

😳 good to hear you are ok!

Thanks Steve :)

Structural basis of inhibition of human NaV1.8 by the tarantula venom peptide Protoxin-I - Nature Communications Animal toxins can modulate action potentials and are important leads for therapeutics. Here, the authors use cryo-EM to show the interaction of the tarantula venom peptide Protoxin-I with a human volt...

Our #CryoEM study on the binding of a Tarantula toxin to a full-length human voltage-gated sodium channel has been published. Very proud of the awesome people in my lab 🥳🥂

www.nature.com/articles/s41...

buckle up out there

Molecular basis of proton sensing by G protein-coupled receptors Three proton-sensing G protein-coupled receptors (GPCRs)—GPR4, GPR65, and GPR68—respond to extracellular pH to regulate diverse physiology. How proton…

Groundbreaking work by @matthewkhoward.bsky.social and Nicholas Hoppe (not on bsky?) from the @willowcoyote.bsky.social @amanglik.bsky.social labs.

Mapping function to structure with deep mutational scanning to resolve the mechanisms of pH sensing GPCRs

www.sciencedirect.com/science/arti...

Ok, trying to bring my community back together... I created a starter pack for lipids and membrane protein aficionados!

Feel free to share, add and distribute, so we can come together again! 😍

go.bsky.app/AEeXh86

I see 2 dolphins and a croc
image from not #cryoem

Happy Birthday Dequina!

Hello there :)

Hello :)

Hello there :)

Maybe a heat shock protein. Like 1E94. Plenty of options though

#cryoem grids don't have to be 3mm do they?

Here is a starter pack for CryoEM/ET enthousiasts
To be completed
go.bsky.app/JmQksC

Hello there :)