CW

How Doodles Became a Cutthroat Billion-Dollar Dog Industry Goldendoodles, labradoodles and bernedoodles are everywhere. Have we finally reached peak doodle?

This @bloomberg.com Businessweek story on the billion-dollar business of Big Doodle is so, so good, as are the photos and the make-a-doodle widget and just…all of it! It’s so good. Gift link: www.bloomberg.com/features/202...

Thanks for sharing. I'll have a proper look when I am less tired.

Skeletal muscle properties in long COVID and ME/CFS differ from those induced by bed rest Patients with long COVID and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) suffer from a reduced exercise capacity, skeletal muscle abnormalities and post-exertional malaise (PEM), where...

That isn't the case according to this paper. www.medrxiv.org/content/10.1...

Skeletal muscle properties in long COVID and ME/CFS differ from those induced by bed rest Patients with long COVID and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) suffer from a reduced exercise capacity, skeletal muscle abnormalities and post-exertional malaise (PEM), where...

They did still find clear differences between the groups - www.medrxiv.org/content/10.1...

A screenshot of an article in the telegraph. The photo accompanying the article has a man sitting on the sofa clutching his head with his hand. Headline below reads: ME is a real illness, genetic study shows

You should check out the Telegraph. A classic of the head clutching genre. Made me want to put my head in my hands.

ME linked to your genetics – early study indicates Scientists said the findings offer the first robust evidence that genes contribute to a person’s chance of developing the disease.

In case you missed it!

📹 C4: ME linked to your genetics - early study indicates

www.channel4.com/news/me-link...

Thanks to all involved - especially to Sarah for sharing her story 🧡

#decodemeresults #decodeme #MECFS #pwME

@decodemestudy.bsky.social
@cgatist.bsky.social
@tessamunt.bsky.social

There's a big feeling of relief for me too. I believed there was likely a genetic underpinning but to have the research show it took just makes everything feel more solid. I'm feeling very emotional.

Professor Chris Ponting, DecodeME lead investigator, University of Edinburgh "This is a wakeup call. These extraordinary results speak the language of people with ME/CFS, often recounting people's ME/CFS symptoms. DecodeME is now calling on researchers worldwide to join us in accelerating ME/CFS research. With our participants we have built an extraordinarily rich DecodeME data set, to which we continue to offer data access. We especially welcome researchers whose work is relevant to the eight signals we have identified, and who could bring their expertise to bear in highly targeted studies that would produce further ME/CFS insights and ultimately treatments."

Message from @cgatist.bsky.social on the #DecodeME results. So exciting! #MECFS

I see The Telegraph went with the clichéd hand stuck on head pose too...it does suck and this has been too long in coming but I do feel a sense of vindication today. I hope this might finally lead to some treatments.

I'm feeling so emotional about this - like you I never dreamed there would be results that feel so definitive.

Chronic fatigue patients have different genes, study finds ‘Groundbreaking’ research finds ‘genetic signals’ for debilitating illness

www.ft.com/content/b827...

And for once a set of headlines that can make us feel validated rather than misunderstood.

Massive well done - this research has been so worthwhile.

I hope this will start a move towards treatment with further research building on the findings. Millions have had their lives devastated by this condition and faced the heartbreaking reality that currently there is nothing much that medicine can offer. I hope this is a sign things are changing. 2/2

I was one of the 20k + people with ME/CFS who took part in this study. I am so pleased the results validate what I think we all knew - this disease has a genetic component and is linked to issues with the immune and neurological systems. 1/2

I was one of the many thousands of people with ME/CFS who took part in this study, and it's fantastic to see the results published as a preprint today. For the first time we have evidence that ME/CFS is partly caused by genes related to the immune & nervous systems. 1/5

I quite like that all the delivery guys are familiar - means you know they care about doing the job well because you are going to see them again. And they are friendly. Did slightly surprise me the time I was walking near my house and one of them honked his horn and yelled a hello out the window.

Such a contrast to a lovely lady near my house. I was trying to plan some new planting for my street and stopped to look at her space - she invited me in, talked me through various things that worked well for her and invited me back to get some cuttings in the Autumn. I guess I was lucky.

Presumably if you reuse the plastic bags rather than getting a hemp bag thereby avoiding more plastic bags and avoiding the charge that would be beneficial?

V interesting.

This is a very Scottish response to EU citizenship. Congratulations.

A city engineer credits lower speed limits and smart design.”

Tools to prevent road death and injury already exist.

Helsinki can do it.

Vision Zero is achievable, no excuses.

www.london.gov.uk/caroline-rus...

The whole thing is horrendous. Totally unnecessary for people earning at the lower end of things and a real burden on sole traders.

The General Theory of Enshittification It isn’t a new phenomenon, but it seems to matter more

Good stuff: Paul Krugman's general theory of enshittification even includes a little dynamic programming model.

Pale green graphic with a bike, a wheelchair, diverse legs with trainers and someone with a stick. Text in Green: Changing the narrative Ending the acceptance of road death in London

🚨 NEW REPORT: Today, I'm proud to launch ‘Changing the Narrative – Ending the Acceptance of Road Death in London’
👉 www.london.gov.uk/caroline-rus...
To mark the launch, I’m hosting a roundtable at City Hall today with campaigners, bereaved families, crash survivors, policy experts, TfL and more.

This is a great article Robert. Such an interesting reflection on the intergenerational nature of autism and shifting perception of what it has meant over time.

Also all documents emailed like this should be password protected and the password sent separately using a different method ( eg text message)

Wonder what they will call it.

Smacks of desperation (theirs not ours)

It's worth revisiting this Jim. Last night there were three separate petitions about the way Tower Hamlets are handling the leases of assets of community value. It would be interesting to know if there is some kind of bigger agenda behind this shift in position at the council.

THE GAP by Ira Glass I think it was in the time of spring 2012, when I came across David Shiyang Liu's lovely piece of work about Ira Glass. It was the most inspiring and motivating…

Reminded of this quote from Ira Glass about the taste gap people have when they start out making creative work. vimeo.com/85040589

@blindboyboatclub.bsky.social covered something similar about it feeling 'cringe' to start out making art or music.

But you just have to batter through it & make more!