Dr Michelle L Halls

Structure of the lysosomal KICSTOR-GATOR1-SAMTOR nutrient-sensing supercomplex This study reveals how KICSTOR and GATOR1 assemble into a crescent-shaped lysosomal complex that regulates mTORC1 during amino acid starvation and how SAMTOR binds KICSTOR in an S-adenosylmethionine-i...

You can find out more here: www.cell.com/cell/fulltex...

This is the result of a fantastic collaboration with @drellisdon.bsky.social at @monashuniversity.bsky.social, including first authors @luptoncj.bsky.social and @charlesbj.bsky.social, and co-lead Yong-Gang (Tyler) Chang. Special mention to Jade Dong and Terrance Lam from my team.

The latest research from our team is out in Cell @cp-cell.bsky.social! We used #cryo-EM, #imaging, #BRET, and #biosensors targeted to the lysosome to understand how the KICSTOR-GATOR1 complex turns off #mTORC1 in response to low levels of amino acids.

Structure of the lysosomal KICSTOR-GATOR1-SAMTOR nutrient-sensing supercomplex This study reveals how KICSTOR and GATOR1 assemble into a crescent-shaped lysosomal complex that regulates mTORC1 during amino acid starvation and how SAMTOR binds KICSTOR in an S-adenosylmethionine-incompatible conformation to couple methionine sensing to mTORC1 regulation.

Now online! Structure of the lysosomal KICSTOR-GATOR1-SAMTOR nutrient-sensing supercomplex

Thrilled to share our latest work @luptoncj.bsky.social @drellisdon.bsky.social @drmlhalls.bsky.social.

Structure of the lysosomal KICSTOR-GATOR1-SAMTOR nutrient-sensing supercomplex.

🧪🔬#cryoEM
Now online @cellpress.bsky.social.

doi.org/10.1016/j.ce...

🏅 Lab Olympics 2025:
From a fun idea to a real tradition, this year we’ve hit a record 6 teams in the winter marquee at MIPS! Science is serious, but these moments of connection, laughter, and (slightly) fierce competition keep us going. Here’s to teamwork and the coveted winner’s button!

🔉 Only a few days left to vote! 🔉
Our 2nd CCeMMP Annual Bench to Art Competition gallery is LIVE! 🤩
ccemmp.org/events/arc-c...

Vote, like and repost :)

#membraneproteins
#scicomm
#nationalscienceweek
#cryoEM
#cryoET

Hox-C12 coordinates β2-adrenoceptor coupling to a cAMP/calcium feedforward loop to drive invasion in triple-negative breast cancer A GPCR and a moonlighting transcription factor together drive metastasis in breast cancer.

New work in #ScienceSignaling may answer why some patients with triple-negative breast cancer who receive beta-blockers have a lower risk of metastasis and identifies a factor that holds promise as a prognostic and therapeutic target. https://scim.ag/45XmD0b

Our latest paper from @monashuniversity.bsky.social Monash Institute of Pharmaceutical Sciences led by #PhD student Terrance Lam is out in Science Signaling today. We investigated how #GPCR #signalling can accelerate invasion in TNBC.

Hayley Gleeson - ABC News

See more terrific pieces from Hayley here.
www.abc.net.au/news/hayley-...

RCSB PDB - 9CE3: Structure of the TSC:WIPI3 lysosomal recruitment complex Structure of the TSC:WIPI3 lysosomal recruitment complex

The PDB files for the TSC:WIPI3 complex have been released today at the PDB. At 40nm across, it is well worth a look 😀🧪

www.rcsb.org/structure/9CE3

Can you add me please?

Our latest study is now online at Science Advances! We report the structure of the gigantic TSC:WIPI3 complex revealing new insights into lysosomal docking and dysregulation in disease. #cryoEM #mTOR 🧪

www.science.org/doi/10.1126/...

Here we are at the start before we were covered in green and blue!

We had a great time yesterday at the Children's Tumour Foundation Australia Conquer #NF in Colour event in Melbourne. It was great to join so many others in supporting the important work of #CTFAustralia, who advocate for and support the 1:3000 people who are diagnosed NF.

Suggesting @lauraem-lab.bsky.social

Suggesting @lauraem-lab.bsky.social

Congratulations to #PhD students @ChantelMastos, @TerranceLamm, and @EricLe_1 who recently won the best talk, people's choice best talk, and best 3MT prizes at the 19th annual HDR symposium and @MIPS_DDB student symposium @MonashPharm @MIPSAustralia 🙌

Bound by the love for cholesterol: A transporter meets a GPCR In a recent issue of Nature, Bayly-Jones et al. report the cryo-EM structures of a lysosomal cholesterol sensor, LYCHOS, also known as GPR155, which reveals a unique fusion of a plant auxin-transporte...

Very exciting! Thanks to Cell Press, Arun Shukla, and the team for the Preview article on our recent advances in uncovering the structure of LYCHOS/GPR155!

www.cell.com/cell/abstrac...

Bound by the love for cholesterol: A transporter meets a GPCR In a recent issue of Nature, Bayly-Jones et al. report the cryo-EM structures of a lysosomal cholesterol sensor, LYCHOS, also known as GPR155, which reveals a unique fusion of a plant auxin-transporte...

Another really nice highlight of our recent work. Arun et al raise interesting points about membrane cross talk and next-steps for LYCHOS. www.cell.com/cell/abstrac...